Medical Subject Headings

Last uploaded: January 31, 2024

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Preferred Name	Thalidomide
Synonyms	Thalomid
Definitions	A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
ID	http://purl.bioontology.org/ontology/MESH/D013792
altLabel	Thalomid Sedoval 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-
AQL	AA AD AE AG AI AN BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR
cui	C0039736 C0729007 C0723668
DC	1
definition	A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
DX	19660101
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000031 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528
Inverse of RB	4Z8R6ORS6L 0
isa	http://purl.bioontology.org/ontology/MESH/D007917 http://purl.bioontology.org/ontology/MESH/D013723 http://purl.bioontology.org/ontology/MESH/D020533 http://purl.bioontology.org/ontology/MESH/D007166
LT	TRD
Mapped from	http://purl.bioontology.org/ontology/MESH/C471702 http://purl.bioontology.org/ontology/MESH/C000599191 http://purl.bioontology.org/ontology/MESH/C101481 http://purl.bioontology.org/ontology/MESH/C115112 http://purl.bioontology.org/ontology/MESH/C011611 http://purl.bioontology.org/ontology/MESH/C516816 http://purl.bioontology.org/ontology/MESH/C540001 http://purl.bioontology.org/ontology/MESH/C467566 http://purl.bioontology.org/ontology/MESH/C108154 http://purl.bioontology.org/ontology/MESH/C470178 http://purl.bioontology.org/ontology/MESH/C060329 http://purl.bioontology.org/ontology/MESH/C006161 http://purl.bioontology.org/ontology/MESH/C505730 http://purl.bioontology.org/ontology/MESH/C513750 http://purl.bioontology.org/ontology/MESH/C524336 http://purl.bioontology.org/ontology/MESH/C494622 http://purl.bioontology.org/ontology/MESH/C494620 http://purl.bioontology.org/ontology/MESH/C494621 http://purl.bioontology.org/ontology/MESH/C060554 http://purl.bioontology.org/ontology/MESH/C477838 http://purl.bioontology.org/ontology/MESH/C490149 http://purl.bioontology.org/ontology/MESH/C452282 http://purl.bioontology.org/ontology/MESH/C088185 http://purl.bioontology.org/ontology/MESH/C000712254 http://purl.bioontology.org/ontology/MESH/C544471 http://purl.bioontology.org/ontology/MESH/C027948 http://purl.bioontology.org/ontology/MESH/C027949 http://purl.bioontology.org/ontology/MESH/C542926 http://purl.bioontology.org/ontology/MESH/C000606252 http://purl.bioontology.org/ontology/MESH/C000712255 http://purl.bioontology.org/ontology/MESH/C114058 http://purl.bioontology.org/ontology/MESH/C487383 http://purl.bioontology.org/ontology/MESH/C562075 http://purl.bioontology.org/ontology/MESH/C100913 http://purl.bioontology.org/ontology/MESH/C455278 http://purl.bioontology.org/ontology/MESH/C001079 http://purl.bioontology.org/ontology/MESH/C000609735 http://purl.bioontology.org/ontology/MESH/C011990
MDA	19990101
MMR	20170524
MN	D03.633.100.513.750.750 D02.241.223.805.810.800 D03.383.621.808.800
notation	D013792
PA	D020533 D013723 D007166 D007917
prefLabel	Thalidomide
RR	50-35-1 (Thalidomide)
TERMUI	T040491 T040492 T620243
TH	US USAN (1961) FDA SRS (2014) UNK (19XX) INN (19XX) USP (19XX) BAN (19XX)
tui	T109 T131 T121
subClassOf	http://purl.bioontology.org/ontology/MESH/D010797 http://purl.bioontology.org/ontology/MESH/D010881

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/SCTSPA/404878004	SCTSPA	CUI
http://purl.bioontology.org/ontology/PDQ/CDR0000042332	PDQ	CUI
http://purl.bioontology.org/ontology/SCTSPA/78702007	SCTSPA	CUI
http://purl.bioontology.org/ontology/RXNORM/10432	RXNORM	CUI
http://purl.bioontology.org/ontology/NDDF/005933	NDDF	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/78702007	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/MSHFRE/D013792	MSHFRE	CUI
http://purl.bioontology.org/ontology/PDQ/CDR0000042332	PDQ	CUI
http://purl.bioontology.org/ontology/ATC/L04AX02	ATC	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/404878004	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148588	NDFRT	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000006367	NDFRT	CUI
http://purl.bioontology.org/ontology/VANDF/4021134	VANDF	CUI
http://purl.bioontology.org/ontology/SNMI/C-64085	SNMI	CUI
http://purl.bioontology.org/ontology/CSP/0397-6187	CRISP	CUI
http://purl.bioontology.org/ontology/RXNORM/220239	RXNORM	CUI
http://purl.obolibrary.org/obo/CHEBI_9513	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9513	CHEBI	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016567	PMAPP-PMO	LOOM
http://purl.bioontology.org/ontology/RXNORM/10432	RXNORM	LOOM
http://purl.obolibrary.org/obo/OMIT_0014645	OMIT	LOOM
http://purl.obolibrary.org/obo/NCIT_C870	BERO	LOOM
http://purl.bioontology.org/ontology/NDDF/005933	NDDF	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/78702007	SNOMEDCT	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C870	NCIT	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148588	ODAE	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000042332	PDQ	LOOM
http://purl.obolibrary.org/obo/CHEBI_74947	FIDEO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.241.223.805.810.800	RH-MESH	LOOM
http://purl.obolibrary.org/obo/CHEBI_9513	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9513	DISDRIV	LOOM
http://purl.obolibrary.org/obo/CHEBI_9513	DINTO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9513	COVID-19	LOOM
http://purl.obolibrary.org/obo/CHEBI_9513	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9513	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_9513	DRON	LOOM
http://purl.jp/bio/4/id/200906035965119250	IOBC	LOOM
http://purl.obolibrary.org/obo/MESH_D013792	BERO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.621.808.800	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.513.750.750	RH-MESH	LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass08828d2b_184c_4083_b9f9_8e82ef976a51	WWECA	LOOM
http://purl.bioontology.org/ontology/ATC/L04AX02	ATC	LOOM
http://purl.obolibrary.org/obo/DRON_00015922	ODNAE	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148588	NDFRT	LOOM
http://stirdf.jst.go.jp/id/200907009440214379	IOBC	LOOM
http://www.drugbank.ca/drugs/DB01041	FTC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#12148	OCHV	LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Thalidomide	APAONTO	LOOM
https://go.drugbank.com/drugs/DB01041	MDM	LOOM
http://www.projecthalo.com/aura#Thalidomide	AURA	LOOM
http://purl.bioontology.org/ontology/VANDF/4021134	VANDF	LOOM
http://purl.bioontology.org/ontology/npo#NPO_434	NPO	LOOM
http://purl.bioontology.org/ontology/SNMI/C-64085	SNMI	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D013792	RH-MESH	LOOM
http://purl.bioontology.org/ontology/CSP/0397-6187	CRISP	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0039736	OCHV	LOOM