loading...| Preferred Name |
Sulindac |
|
| Synonyms |
Klinoril |
|
| Definitions |
A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects. |
|
| ID |
http://purl.bioontology.org/ontology/MESH/D013467 |
|
| altLabel |
Klinoril MK 231 Apo-Sulin Copal Apo Sulin Nu Sulindac Novo Sundac Aclin Sulindal Novo-Sundac Arthrocine Clinoril 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-, (Z)- Nu-Sulindac Arthrobid Chibret Kenalin MK-231 MK231 |
|
| AQL |
AA AD AE AG AI AN BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR |
|
| cui |
C1564277 C0733670 C1564274 C0733672 C1515045 C1564276 C1564275 C1564273 C0038792 C0591267 C1515040 |
|
| DC |
1 |
|
| definition |
A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects. |
|
| DX |
19900101 |
|
| HN |
90(79); was see under INDENES 1979-89 |
|
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000031 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 |
|
| Inverse of RB |
184SNS8VUH 0 |
|
| isa |
http://purl.bioontology.org/ontology/MESH/D000894 |
|
| LT |
TRD |
|
| Machine permutation |
90; was see under INDENES 1979-89 |
|
| Mapped from |
http://purl.bioontology.org/ontology/MESH/C439285 http://purl.bioontology.org/ontology/MESH/C508487 http://purl.bioontology.org/ontology/MESH/C025463 http://purl.bioontology.org/ontology/MESH/C025462 http://purl.bioontology.org/ontology/MESH/C000629487 http://purl.bioontology.org/ontology/MESH/C526537 http://purl.bioontology.org/ontology/MESH/C452601 http://purl.bioontology.org/ontology/MESH/C543001 http://purl.bioontology.org/ontology/MESH/C539817 http://purl.bioontology.org/ontology/MESH/C553002 |
|
| MDA |
19780208 |
|
| MMR |
20160701 |
|
| MN |
D04.615.486.875 D02.455.426.559.847.486.875 |
|
| notation |
D013467 |
|
| PA |
D000894 D000970 D016861 |
|
| prefLabel |
Sulindac |
|
| RR |
38194-50-2 (Sulindac) |
|
| TERMUI |
T619217 T039516 T619211 T619224 T619219 T039519 T619223 T039517 T619213 T039518 T039514 T619221 T619215 T039515 |
|
| TH |
US MX UK NL CA NLM (1990) FDA SRS (2014) ES UNK (19XX) INN (19XX) AU USAN (1975) USP (19XX) BAN (19XX) FR IE |
|
| tui |
T109 T121 |
|
| subClassOf |