Medical Subject Headings

Last uploaded: January 31, 2024

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Preferred Name	Tissue Plasminogen Activator
Synonyms	Activase Tissue-Type Plasminogen Activator
Definitions	A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.
ID	http://purl.bioontology.org/ontology/MESH/D010959
altLabel	Activase Plasminogen Activator, Tissue-Type Lysatec rt-PA Tissue Activator D-44 Lysatec rt PA Plasminogen Activator, Tissue Tisokinase Alteplase Lysatec rtPA T-Plasminogen Activator TTPA Tissue Type Plasminogen Activator Tissue Activator D 44 Plasminogen Activator, Tissue Type T Plasminogen Activator Actilyse Tissue-Type Plasminogen Activator
AQL	AD AE AI AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR
cui	C0032143 C0678113 C0701942
DC	1
definition	A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.
DX	19860101
HN	98(86)
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000172 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000648 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528
Inverse of RB	EC 3.4.21.68 0
isa	http://purl.bioontology.org/ontology/MESH/D005343
LT	TRD
Machine permutation	98; see ALTEPLASE 1992-97; see PLASMINOGEN ACTIVATOR, TISSUE-TYPE 1986-91
Mapped from	http://purl.bioontology.org/ontology/MESH/C067262 http://purl.bioontology.org/ontology/MESH/C081981 http://purl.bioontology.org/ontology/MESH/C083865 http://purl.bioontology.org/ontology/MESH/C083866 http://purl.bioontology.org/ontology/MESH/C567341 http://purl.bioontology.org/ontology/MESH/C072781 http://purl.bioontology.org/ontology/MESH/C059835 http://purl.bioontology.org/ontology/MESH/C550736 http://purl.bioontology.org/ontology/MESH/C087896 http://purl.bioontology.org/ontology/MESH/C068645 http://purl.bioontology.org/ontology/MESH/C065621 http://purl.bioontology.org/ontology/MESH/C104096 http://purl.bioontology.org/ontology/MESH/C085027 http://purl.bioontology.org/ontology/MESH/C449559 http://purl.bioontology.org/ontology/MESH/C080391 http://purl.bioontology.org/ontology/MESH/C089949 http://purl.bioontology.org/ontology/MESH/C473928 http://purl.bioontology.org/ontology/MESH/C077412 http://purl.bioontology.org/ontology/MESH/C065736
MDA	19850612
MMR	20160701
MN	D08.811.277.656.959.350.875 D12.776.124.125.662.768 D23.119.970 D08.811.277.656.300.760.875
notation	D010959
PA	D005343
prefLabel	Tissue Plasminogen Activator
RR	105857-23-6 (Alteplase)
TERMUI	T707756 T032269 T032270 T032272 T365869 T032267 T032271 T032266 T505964 T032273 T032268
TH	US MX NLM (2009) UK NLM (2000) NL NLM (1999) CA JAN (19XX) ES NLM (1992) UNK (19XX) INN (19XX) DE AU NLM (1998) BAN (19XX) USAN (1989) IE
tui	T116 T126 T121
subClassOf	http://purl.bioontology.org/ontology/MESH/D012697 http://purl.bioontology.org/ontology/MESH/D001779 http://purl.bioontology.org/ontology/MESH/D010960

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/MSHFRE/D010959	MSHFRE	CUI
http://purl.bioontology.org/ontology/MSHFRE/D010959	MSHFRE	CUI
http://purl.bioontology.org/ontology/MSHFRE/D010959	MSHFRE	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000007047	NDFRT	CUI
http://purl.bioontology.org/ontology/ATC/B01AD02	ATC	CUI
http://purl.bioontology.org/ontology/RCD/bv3..	RCD	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/108997009	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/SNMI/F-D7A20	SNMI	CUI
http://purl.bioontology.org/ontology/SCTSPA/108997009	SCTSPA	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387152000	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/LNC/LP16891-1	LOINC	CUI
http://purl.bioontology.org/ontology/SCTSPA/27638005	SCTSPA	CUI
http://purl.bioontology.org/ontology/SCTSPA/37411004	SCTSPA	CUI
http://purl.bioontology.org/ontology/SCTSPA/387152000	SCTSPA	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000147695	NDFRT	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/27638005	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/VANDF/4019319	VANDF	CUI
http://purl.bioontology.org/ontology/PDQ/CDR0000042033	PDQ	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/37411004	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/SNMI/C-A7410	SNMI	CUI
http://purl.bioontology.org/ontology/ATC/S01XA13	ATC	CUI
http://purl.bioontology.org/ontology/RXNORM/8410	RXNORM	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000147508	NDFRT	CUI
http://purl.bioontology.org/ontology/NDDF/002074	NDDF	CUI
http://purl.bioontology.org/ontology/CSP/0437-7160	CRISP	CUI
http://purl.bioontology.org/ontology/VANDF/4019599	VANDF	CUI
http://purl.bioontology.org/ontology/LNC/MTHU019721	LOINC	CUI
http://purl.bioontology.org/ontology/RCD/x02Sk	RCD	CUI
http://purl.bioontology.org/ontology/PDQ/CDR0000042033	PDQ	CUI
http://purl.bioontology.org/ontology/SNMI/C-C1080	SNMI	CUI
http://purl.bioontology.org/ontology/RXNORM/204210	RXNORM	CUI
http://www.phoc.org.cn/pmo/class/PMO_00019676	PMAPP-PMO	LOOM
http://www.semanticweb.org/ontologies/STO.owl#OWLClass_e7712dbb_ef45_4044_990c_203b584b3d10	STO-DRAFT	LOOM
http://www.semanticweb.org/ontologies/STO.owl#OWLClass_e7712dbb_ef45_4044_990c_203b584b3d10	CVAO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D08.811.277.656.959.350.875	RH-MESH	LOOM
http://purl.obolibrary.org/obo/OMIT_0011932	OMIT	LOOM
http://purl.bioontology.org/ontology/SNMI/F-D7A20	SNMI	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D010959	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.776.124.125.662.768	RH-MESH	LOOM
http://purl.obolibrary.org/obo/MESH_D010959	BERO	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/37411004	SNOMEDCT	LOOM
http://www.semanticweb.org/cjf/ontologies/2022/8/NeuralReprogrammingOntology(NRO)#tissue_plasminogen_activator	NRO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D08.811.277.656.300.760.875	RH-MESH	LOOM
http://uri.neuinfo.org/nif/nifstd/sao681020632	NIFSTD	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D23.119.970	RH-MESH	LOOM
http://ccdb.ucsd.edu/SAO/1.2#sao681020632	SAO	LOOM