loading...| Preferred Name |
Peptidyl-Dipeptidase A |
|
| Synonyms |
Angiotensin I Converting Enzyme |
|
| Definitions |
A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of ANGIOTENSIN I to ANGIOTENSIN II, with increase in vasoconstrictor activity, but no action on angiotensin II. It is also able to inactivate BRADYKININ, a potent vasodilator; and has a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. (From https://www.uniprot.org April 15, 2020). |
|
| ID |
http://purl.bioontology.org/ontology/MESH/D007703 |
|
| altLabel |
Angiotensin I Converting Enzyme Angiotensin Converting Enzyme 1 Angiotensin I-Converting Enzyme Dipeptidyl Carboxypeptidase I ACE1 Angiotensin Converting Enzyme 1 ACE1 Protein CD143 Antigens Carboxypeptidase I, Dipeptidyl Antigens, CD143 ACE1 Angiotensin-Converting Enzyme 1 Kininase A Peptidase P Kininase II Carboxycathepsin Dipeptidyl Peptidase A Peptidyl Dipeptidase A Angiotensin Converting Enzyme |
|
| AQL |
AD AE AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR |
|
| cui |
C0022709 |
|
| DC |
1 |
|
| definition |
A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of ANGIOTENSIN I to ANGIOTENSIN II, with increase in vasoconstrictor activity, but no action on angiotensin II. It is also able to inactivate BRADYKININ, a potent vasodilator; and has a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. (From https://www.uniprot.org April 15, 2020). |
|
| DX |
19740101 |
|
| EC |
antagonists & inhibitors:Angiotensin-Converting Enzyme Inhibitors |
|
| HN |
1994; for TONIN use KININASE II 1984-93 |
|
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000172 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000648 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 |
|
| Inverse of RB |
EC 3.4.15.1 |
|
| Machine permutation |
1994; see KININASE II 1974-93; for TONIN see KININASE II 1984-93 |
|
| Mapped from |
http://purl.bioontology.org/ontology/MESH/C000612092 http://purl.bioontology.org/ontology/MESH/C104431 |
|
| MDA |
19990101 |
|
| MMR |
20210630 |
|
| MN |
D08.811.277.656.350.350.687 |
|
| notation |
D007703 |
|
| prefLabel |
Peptidyl-Dipeptidase A |
|
| TERMUI |
T023117 T001078628 T001104344 T001104345 T023121 T023122 T023120 T001078629 T001078627 T023116 T023115 T023123 T023119 T023118 |
|
| TH |
NLM (1973) NLM (1999) NLM (1994) UNK (19XX) NLM (2022) NLM (2021) |
|
| tui |
T116 T129 T126 |
|
| subClassOf |