Medical Subject Headings

Last uploaded: January 31, 2024
Preferred Name

Clozapine

Synonyms

Clozaril

Definitions

A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.

ID

http://purl.bioontology.org/ontology/MESH/D003024

altLabel

Clozaril

Leponex

5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-

AQL

AA AD AE AG AI AN BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR

cui

C0719386

C0009079

C0733560

DC

1

definition

A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.

DX

19910101

HN

91(75); was see under DIBENZAZEPINES 1975-90

Inverse of AQ

http://purl.bioontology.org/ontology/MESH/Q000097

http://purl.bioontology.org/ontology/MESH/Q000627

http://purl.bioontology.org/ontology/MESH/Q000493

http://purl.bioontology.org/ontology/MESH/Q000494

http://purl.bioontology.org/ontology/MESH/Q000276

http://purl.bioontology.org/ontology/MESH/Q000138

http://purl.bioontology.org/ontology/MESH/Q000134

http://purl.bioontology.org/ontology/MESH/Q000266

http://purl.bioontology.org/ontology/MESH/Q000378

http://purl.bioontology.org/ontology/MESH/Q000008

http://purl.bioontology.org/ontology/MESH/Q000009

http://purl.bioontology.org/ontology/MESH/Q000031

http://purl.bioontology.org/ontology/MESH/Q000032

http://purl.bioontology.org/ontology/MESH/Q000037

http://purl.bioontology.org/ontology/MESH/Q000191

http://purl.bioontology.org/ontology/MESH/Q000302

http://purl.bioontology.org/ontology/MESH/Q000145

http://purl.bioontology.org/ontology/MESH/Q000592

http://purl.bioontology.org/ontology/MESH/Q000737

http://purl.bioontology.org/ontology/MESH/Q000819

http://purl.bioontology.org/ontology/MESH/Q000506

http://purl.bioontology.org/ontology/MESH/Q000633

http://purl.bioontology.org/ontology/MESH/Q000600

http://purl.bioontology.org/ontology/MESH/Q000652

http://purl.bioontology.org/ontology/MESH/Q000528

Inverse of RB

J60AR2IKIC

0

isa

http://purl.bioontology.org/ontology/MESH/D018756

http://purl.bioontology.org/ontology/MESH/D012702

http://purl.bioontology.org/ontology/MESH/D014150

LT

TRD

Machine permutation

91; was see under DIBENZAZEPINES 1975-90

Mapped from

http://purl.bioontology.org/ontology/MESH/C079149

http://purl.bioontology.org/ontology/MESH/C094038

http://purl.bioontology.org/ontology/MESH/C086632

http://purl.bioontology.org/ontology/MESH/C586625

http://purl.bioontology.org/ontology/MESH/C408612

http://purl.bioontology.org/ontology/MESH/C093454

http://purl.bioontology.org/ontology/MESH/C061854

http://purl.bioontology.org/ontology/MESH/C061853

http://purl.bioontology.org/ontology/MESH/C061855

http://purl.bioontology.org/ontology/MESH/C045393

http://purl.bioontology.org/ontology/MESH/C045392

http://purl.bioontology.org/ontology/MESH/C522904

http://purl.bioontology.org/ontology/MESH/C108260

http://purl.bioontology.org/ontology/MESH/C000726499

http://purl.bioontology.org/ontology/MESH/C058272

http://purl.bioontology.org/ontology/MESH/C411706

MDA

19741119

MMR

20160528

MN

D03.633.300.240.220

notation

D003024

PA

D012702

D014150

D018756

prefLabel

Clozapine

RR

5786-21-0 (Clozapine)

TERMUI

T008783

T008784

T008785

TH

FDA SRS (2014)

NLM (1992)

UNK (19XX)

INN (19XX)

USAN (1969)

USP (19XX)

BAN (19XX)

tui

T109

T121

subClassOf

http://purl.bioontology.org/ontology/MESH/D003984

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http://purl.bioontology.org/ontology/RCD/x03wV RCD CUI
http://purl.bioontology.org/ontology/MSHFRE/D003024 MSHFRE CUI
http://purl.bioontology.org/ontology/RXNORM/216102 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/2626 RXNORM CUI
http://purl.bioontology.org/ontology/SNMI/C-63420 SNMI CUI
http://purl.bioontology.org/ontology/VANDF/4019488 VANDF CUI
http://purl.bioontology.org/ontology/CSP/0314-4862 CRISP CUI
http://purl.bioontology.org/ontology/ATC/N05AH02 ATC CUI
http://purl.bioontology.org/ontology/VANDF/4040180 VANDF CUI
http://purl.bioontology.org/ontology/NDFRT/N0000147608 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000193728 NDFRT CUI
http://purl.bioontology.org/ontology/LNC/LP17236-8 LOINC CUI
http://purl.bioontology.org/ontology/RCD/d4l.. RCD CUI
http://purl.bioontology.org/ontology/NDFRT/N0000193637 NDFRT CUI
http://purl.bioontology.org/ontology/NDDF/003526 NDDF CUI
http://purl.bioontology.org/ontology/NDFRT/N0000006585 NDFRT CUI
http://purl.bioontology.org/ontology/SCTSPA/387568001 SCTSPA CUI
http://purl.bioontology.org/ontology/SNOMEDCT/96221003 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SCTSPA/96221003 SCTSPA CUI
http://purl.bioontology.org/ontology/VANDF/4037345 VANDF CUI
http://purl.bioontology.org/ontology/VANDF/4036908 VANDF CUI
http://purl.bioontology.org/ontology/LNC/MTHU060461 LOINC CUI
http://purl.bioontology.org/ontology/VANDF/4037056 VANDF CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387568001 SNOMEDCT CUI
http://purl.obolibrary.org/obo/CHEBI_3766 OBA LOOM
http://purl.obolibrary.org/obo/XCO_0001149 XCO LOOM
http://www.case.edu/EpilepsyOntology.owl#Clozapine EPSO LOOM
http://purl.jp/bio/4/id/200906010315840084 IOBC LOOM
http://purl.bioontology.org/ontology/RXNORM/2626 RXNORM LOOM
http://purl.bioontology.org/ontology/SNMI/C-63420 SNMI LOOM
http://www.drugbank.ca/drugs/DB00363 FTC LOOM
http://purl.bioontology.org/ontology/VANDF/4019488 VANDF LOOM
http://purl.bioontology.org/ontology/CSP/0314-4862 CRISP LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0009079 OCHV LOOM
http://purl.bioontology.org/ontology/ATC/N05AH02 ATC LOOM
http://bmi.utah.edu/ontologies/hfontology/C0009079 HFO LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Clozapine APAONTO LOOM
http://stirdf.jst.go.jp/id/200907078191585002 IOBC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#3080 OCHV LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147608 NDFRT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D003024 RH-MESH LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017964 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/LNC/LP17236-8 LOINC LOOM
http://purl.obolibrary.org/obo/CHEBI_3766 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_3766 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_3766 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_3766 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_3766 HOIP LOOM
http://purl.obolibrary.org/obo/CHEBI_3766 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_3766 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_3766 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_3766 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_3766 OBA LOOM
http://purl.obolibrary.org/obo/CHEBI_3766 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_3766 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_3766 GO-PLUS LOOM
http://purl.bioontology.org/ontology/RCD/d4l.. RCD LOOM
http://scai.fraunhofer.de/AlzheimerOntology#clozapine ADO LOOM
http://purl.bioontology.org/ontology/NDDF/003526 NDDF LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass932c0f47_bb57_4af6_8363_b1a0865e0abc WWECA LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass2ef82e3f_2080_48b9_9bdc_911c8602ab28 WWECA LOOM
http://purl.obolibrary.org/obo/OMIT_0004334 OMIT LOOM
http://purl.obolibrary.org/obo/MESH_D003024 BERO LOOM
http://www.co-ode.org/ontologies/galen#Clozapine GALEN LOOM
http://purl.bioontology.org/ontology/CPT/80159 CPT LOOM
https://go.drugbank.com/drugs/DB00363 MDM LOOM
http://purl.bioontology.org/ontology/LNC/MTHU060461 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.494.240.220 RH-MESH LOOM
http://www.case.edu/EpSO.owl#Clozapine MEPO LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28936 NCIT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387568001 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/NCIT_C28936 BERO LOOM