Preferred Name |
Clozapine |
|
Synonyms |
Clozaril |
|
Definitions |
A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent. |
|
ID |
http://purl.bioontology.org/ontology/MESH/D003024 |
|
altLabel |
Clozaril Leponex 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)- |
|
AQL |
AA AD AE AG AI AN BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR |
|
cui |
C0719386 C0009079 C0733560 |
|
DC |
1 |
|
definition |
A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent. |
|
DX |
19910101 |
|
HN |
91(75); was see under DIBENZAZEPINES 1975-90 |
|
Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000031 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 |
|
Inverse of RB |
J60AR2IKIC 0 |
|
isa |
http://purl.bioontology.org/ontology/MESH/D018756 |
|
LT |
TRD |
|
Machine permutation |
91; was see under DIBENZAZEPINES 1975-90 |
|
Mapped from |
http://purl.bioontology.org/ontology/MESH/C079149 http://purl.bioontology.org/ontology/MESH/C094038 http://purl.bioontology.org/ontology/MESH/C086632 http://purl.bioontology.org/ontology/MESH/C586625 http://purl.bioontology.org/ontology/MESH/C408612 http://purl.bioontology.org/ontology/MESH/C093454 http://purl.bioontology.org/ontology/MESH/C061854 http://purl.bioontology.org/ontology/MESH/C061853 http://purl.bioontology.org/ontology/MESH/C061855 http://purl.bioontology.org/ontology/MESH/C045393 http://purl.bioontology.org/ontology/MESH/C045392 http://purl.bioontology.org/ontology/MESH/C522904 http://purl.bioontology.org/ontology/MESH/C108260 http://purl.bioontology.org/ontology/MESH/C000726499 |
|
MDA |
19741119 |
|
MMR |
20160528 |
|
MN |
D03.633.300.240.220 |
|
notation |
D003024 |
|
PA |
D012702 D014150 D018756 |
|
prefLabel |
Clozapine |
|
RR |
5786-21-0 (Clozapine) |
|
TERMUI |
T008783 T008784 T008785 |
|
TH |
FDA SRS (2014) NLM (1992) UNK (19XX) INN (19XX) USAN (1969) USP (19XX) BAN (19XX) |
|
tui |
T109 T121 |
|
subClassOf |