Preferred Name |
Botulinum Toxins |
|
Synonyms |
Clostridium botulinum Toxins Toxins, Clostridium botulinum |
|
Definitions |
Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS. |
|
ID |
http://purl.bioontology.org/ontology/MESH/D001905 |
|
altLabel |
Clostridium botulinum Toxins Botulinum Neurotoxin Botulinum Neurotoxins Toxin, Botulinum Neurotoxin, Botulinum Botulin Toxins, Botulinum Neurotoxins, Botulinum Botulinum Toxin Toxins, Clostridium botulinum |
|
AN |
/antag permitted but consider also BOTULINUM ANTITOXIN |
|
AQL |
AD AE AG AI AN BI BL CF CH CL CS DE EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR |
|
cui |
C0006055 |
|
DC |
1 |
|
definition |
Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS. |
|
DX |
19720101 |
|
FX |
D001906 |
|
HN |
78; was BOTULINUM TOXIN 1969-77 (Prov 1969-71) |
|
Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000648 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 |
|
Inverse of RB |
EC 3.4.24.69 |
|
Inverse of RO |
http://purl.bioontology.org/ontology/MESH/D001906 |
|
isa | ||
Machine permutation |
78; was BOTULINUM TOXIN 1972-77 |
|
Mapped from |
http://purl.bioontology.org/ontology/MESH/C118973 http://purl.bioontology.org/ontology/MESH/C088300 http://purl.bioontology.org/ontology/MESH/C080139 http://purl.bioontology.org/ontology/MESH/C488535 http://purl.bioontology.org/ontology/MESH/C096325 http://purl.bioontology.org/ontology/MESH/C096326 http://purl.bioontology.org/ontology/MESH/C096324 http://purl.bioontology.org/ontology/MESH/C096321 http://purl.bioontology.org/ontology/MESH/C405517 http://purl.bioontology.org/ontology/MESH/C405516 http://purl.bioontology.org/ontology/MESH/C063007 |
|
MDA |
19990101 |
|
MMR |
20200527 |
|
MN |
D08.811.277.656.675.374.153 D23.946.123.179 D08.811.277.656.300.480.153 D12.776.097.156 |
|
notation |
D001905 |
|
OL |
use BOTULINUM TOXINS to search BOTULINUM TOXIN 1969-77 (as Prov 1969-71) |
|
PA |
D009498 D065087 |
|
prefLabel |
Botulinum Toxins |
|
TERMUI |
T005422 T005421 T005420 T001006299 T001006298 T005419 |
|
TH |
NLM (1969) UNK (19XX) NLM (2021) |
|
tui |
T116 T131 T121 |
|
subClassOf |
http://purl.bioontology.org/ontology/MESH/D008666 |