Medical Subject Headings

Last uploaded: January 31, 2024
Preferred Name

Botulinum Toxins

Synonyms

Clostridium botulinum Toxins

Toxins, Clostridium botulinum

Definitions

Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS.

ID

http://purl.bioontology.org/ontology/MESH/D001905

altLabel

Clostridium botulinum Toxins

Botulinum Neurotoxin

Botulinum Neurotoxins

Toxin, Botulinum

Neurotoxin, Botulinum

Botulin

Toxins, Botulinum

Neurotoxins, Botulinum

Botulinum Toxin

Toxins, Clostridium botulinum

AN

/antag permitted but consider also BOTULINUM ANTITOXIN

AQL

AD AE AG AI AN BI BL CF CH CL CS DE EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR

cui

C0006055

DC

1

definition

Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS.

DX

19720101

FX

D001906

HN

78; was BOTULINUM TOXIN 1969-77 (Prov 1969-71)

Inverse of AQ

http://purl.bioontology.org/ontology/MESH/Q000097

http://purl.bioontology.org/ontology/MESH/Q000096

http://purl.bioontology.org/ontology/MESH/Q000627

http://purl.bioontology.org/ontology/MESH/Q000648

http://purl.bioontology.org/ontology/MESH/Q000493

http://purl.bioontology.org/ontology/MESH/Q000494

http://purl.bioontology.org/ontology/MESH/Q000276

http://purl.bioontology.org/ontology/MESH/Q000138

http://purl.bioontology.org/ontology/MESH/Q000134

http://purl.bioontology.org/ontology/MESH/Q000266

http://purl.bioontology.org/ontology/MESH/Q000378

http://purl.bioontology.org/ontology/MESH/Q000008

http://purl.bioontology.org/ontology/MESH/Q000009

http://purl.bioontology.org/ontology/MESH/Q000032

http://purl.bioontology.org/ontology/MESH/Q000037

http://purl.bioontology.org/ontology/MESH/Q000191

http://purl.bioontology.org/ontology/MESH/Q000302

http://purl.bioontology.org/ontology/MESH/Q000145

http://purl.bioontology.org/ontology/MESH/Q000592

http://purl.bioontology.org/ontology/MESH/Q000737

http://purl.bioontology.org/ontology/MESH/Q000819

http://purl.bioontology.org/ontology/MESH/Q000502

http://purl.bioontology.org/ontology/MESH/Q000506

http://purl.bioontology.org/ontology/MESH/Q000187

http://purl.bioontology.org/ontology/MESH/Q000235

http://purl.bioontology.org/ontology/MESH/Q000633

http://purl.bioontology.org/ontology/MESH/Q000600

http://purl.bioontology.org/ontology/MESH/Q000652

http://purl.bioontology.org/ontology/MESH/Q000528

Inverse of RB

EC 3.4.24.69

Inverse of RO

http://purl.bioontology.org/ontology/MESH/D001906

http://purl.bioontology.org/ontology/MESH/D003014

http://purl.bioontology.org/ontology/MESH/D018678

isa

http://purl.bioontology.org/ontology/MESH/D065087

http://purl.bioontology.org/ontology/MESH/D009498

Machine permutation

78; was BOTULINUM TOXIN 1972-77

Mapped from

http://purl.bioontology.org/ontology/MESH/C118973

http://purl.bioontology.org/ontology/MESH/C088300

http://purl.bioontology.org/ontology/MESH/C080139

http://purl.bioontology.org/ontology/MESH/C488535

http://purl.bioontology.org/ontology/MESH/C096325

http://purl.bioontology.org/ontology/MESH/C096326

http://purl.bioontology.org/ontology/MESH/C096324

http://purl.bioontology.org/ontology/MESH/C096321

http://purl.bioontology.org/ontology/MESH/C405517

http://purl.bioontology.org/ontology/MESH/C405516

http://purl.bioontology.org/ontology/MESH/C063007

http://purl.bioontology.org/ontology/MESH/C527269

http://purl.bioontology.org/ontology/MESH/C585484

MDA

19990101

MMR

20200527

MN

D08.811.277.656.675.374.153

D23.946.123.179

D08.811.277.656.300.480.153

D12.776.097.156

notation

D001905

OL

use BOTULINUM TOXINS to search BOTULINUM TOXIN 1969-77 (as Prov 1969-71)

PA

D009498

D065087

prefLabel

Botulinum Toxins

TERMUI

T005422

T005421

T005420

T001006299

T001006298

T005419

TH

NLM (1969)

UNK (19XX)

NLM (2021)

tui

T116

T131

T121

subClassOf

http://purl.bioontology.org/ontology/MESH/D008666

http://purl.bioontology.org/ontology/MESH/D001427

http://purl.bioontology.org/ontology/MESH/D001426

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/MEDLINEPLUS/C0006055 MEDLINEPLUS CUI
http://purl.bioontology.org/ontology/ATC/M03AX01 ATC CUI
http://purl.bioontology.org/ontology/LNC/LP18030-4 LOINC CUI
http://purl.bioontology.org/ontology/LNC/MTHU002713 LOINC CUI
http://purl.bioontology.org/ontology/SNMI/C-36304 SNMI CUI
http://purl.bioontology.org/ontology/RCD/X79DH RCD CUI
http://purl.bioontology.org/ontology/NDFRT/N0000004422 NDFRT CUI
http://purl.bioontology.org/ontology/MSHFRE/D001905 MSHFRE CUI
http://purl.bioontology.org/ontology/SNOMEDCT/11894001 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SCTSPA/419254007 SCTSPA CUI
http://purl.bioontology.org/ontology/SCTSPA/11894001 SCTSPA CUI
http://purl.bioontology.org/ontology/SNOMEDCT/419254007 SNOMEDCT CUI
http://purl.bioontology.org/ontology/CSP/1556-7393 CRISP CUI
http://purl.obolibrary.org/obo/MESH_D001905 BERO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D08.811.277.656.300.480.153 RH-MESH LOOM
http://purl.obolibrary.org/obo/OMIT_0003262 OMIT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#2113 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.776.097.156 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D23.946.123.179 RH-MESH LOOM
http://id.nlm.nih.gov/mesh/D001905 MDM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D08.811.277.656.675.374.153 RH-MESH LOOM
http://www.phoc.org.cn/pmo/class/PMO_00019628 PMAPP-PMO LOOM
http://www.limics.fr/ontologies/ontoparonmed#ToxineBotulique ONTOPARON LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D001905 RH-MESH LOOM