Hearing Impairment Ontology

Last uploaded: October 31, 2019
Preferred Name

Gentamicin

Synonyms
Definitions

A broad-spectrum aminoglycoside antibiotic produced by fermentation of Micromonospora purpurea or M. echinospora. Gentamicin is an antibiotic complex consisting of four major (C1, C1a, C2, and C2a) and several minor components. This agent irreversibly binds to the bacterial 30S ribosomal subunit. Specifically, this antibiotic is lodged between 16S rRNA and S12 protein within the 30S subunit. This leads to interference with translational initiation complex, misreading of mRNA, thereby hampering protein synthesis and resulting in bactericidal effect. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses.

ID

http://purl.obolibrary.org/obo/HIO_0000278

description

A broad-spectrum aminoglycoside antibiotic produced by fermentation of Micromonospora purpurea or M. echinospora. Gentamicin is an antibiotic complex consisting of four major (C1, C1a, C2, and C2a) and several minor components. This agent irreversibly binds to the bacterial 30S ribosomal subunit. Specifically, this antibiotic is lodged between 16S rRNA and S12 protein within the 30S subunit. This leads to interference with translational initiation complex, misreading of mRNA, thereby hampering protein synthesis and resulting in bactericidal effect. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses.

created_by

Jade Hotchkiss

creation_date

2019-08-01T07:09:06.598586Z

database cross reference

NCIT:C519

definition source

http://purl.obolibrary.org/obo/NCIT_C519

existence in other ontologies

Sufficient

hasExactSynonym

Gentamycin Complex

Genoptic S.O.P.

Garamicin

Garamycin

Genoptic

Gentamycin

U-Gencin

label

Gentamicin

prefixIRI

HIO:0000278

prefLabel

Gentamicin

subClassOf

http://purl.obolibrary.org/obo/HIO_0000240

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http://purl.bioontology.org/ontology/CSP/0191-7691 CRISP LOOM
http://purl.bioontology.org/ontology/ATC/S03AA06 ATC LOOM
http://purl.bioontology.org/ontology/ATC/J01GB03 ATC LOOM
http://purl.obolibrary.org/obo/DRON_00730841 PDRO LOOM
http://purl.bioontology.org/ontology/VANDF/4019765 VANDF LOOM
http://www.phoc.org.cn/pmo/class/PMO_00025743 PMAPP-PMO LOOM
http://www.co-ode.org/ontologies/galen#Gentamicin GALEN LOOM
http://purl.bioontology.org/ontology/RXNORM/1596450 RXNORM LOOM
http://purl.bioontology.org/ontology/ATC/S02AA14 ATC LOOM
http://purl.bioontology.org/ontology/CPT/80170 CPT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0017436 OCHV LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C519 NCIT LOOM
http://purl.obolibrary.org/obo/NCIT_C519 BERO LOOM
http://purl.obolibrary.org/obo/NCIT_C519 SCDO LOOM
http://purl.obolibrary.org/obo/dinto_DB00798 DINTO LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039250 PDQ LOOM
http://purl.obolibrary.org/obo/CHEBI_17833 HOIP LOOM
http://purl.obolibrary.org/obo/CHEBI_17833 TXPO LOOM
http://purl.jp/bio/4/id/200906052661342087 IOBC LOOM
http://purl.bioontology.org/ontology/SNMI/C-52530 SNMI LOOM
https://go.drugbank.com/drugs/DB00798 MDM LOOM
http://purl.bioontology.org/ontology/LNC/MTHU004260 LOINC LOOM
http://purl.bioontology.org/ontology/ATC/D06AX07 ATC LOOM
http://purl.bioontology.org/ontology/NDDF/004898 NDDF LOOM
http://id.nlm.nih.gov/mesh/D005839 MDM LOOM
http://purl.bioontology.org/ontology/LNC/LP15747-6 LOINC LOOM
http://www.drugbank.ca/drugs/DB00798 FTC LOOM
http://purl.obolibrary.org/obo/ARO_3007382 ARO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147856 NDFRT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387321007 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/ATC/S01AA11 ATC LOOM