Human Interaction Network Ontology

Last uploaded: June 27, 2014
Preferred Name

Metabolism

Synonyms
Definitions

Metabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as the inactivation and elimination of toxic ones generated endogenously or present in the extracellular environment. The processes of energy metabolism can be classified into two groups according to whether they involve carbohydrate-derived or lipid-derived molecules, and within each group it is useful to distinguish processes that mediate the breakdown and oxidation of these molecules to yield energy from ones that mediate their synthesis and storage as internal energy reserves. Synthetic reactions are conveniently grouped by the chemical nature of the end products, such as nucleotides, amino acids and related molecules, and porphyrins. Detoxification reactions (biological oxidations) are likewise conveniently classified by the chemical nature of the toxin.<p>At the same time, all of these processes are tightly integrated. Intermediates in reactions of energy generation are starting materials for biosyntheses of amino acids and other compounds, broad-specificity oxidoreductase enzymes can be involved in both detoxification reactions and biosyntheses, and hormone-mediated signaling processes function to coordinate the operation of energy-generating and energy-storing reactions and to couple these to other biosynthetic processes.

ID

http://purl.obolibrary.org/obo/HINO_0015266

comment

Metabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as the inactivation and elimination of toxic ones generated endogenously or present in the extracellular environment. The processes of energy metabolism can be classified into two groups according to whether they involve carbohydrate-derived or lipid-derived molecules, and within each group it is useful to distinguish processes that mediate the breakdown and oxidation of these molecules to yield energy from ones that mediate their synthesis and storage as internal energy reserves. Synthetic reactions are conveniently grouped by the chemical nature of the end products, such as nucleotides, amino acids and related molecules, and porphyrins. Detoxification reactions (biological oxidations) are likewise conveniently classified by the chemical nature of the toxin.

At the same time, all of these processes are tightly integrated. Intermediates in reactions of energy generation are starting materials for biosyntheses of amino acids and other compounds, broad-specificity oxidoreductase enzymes can be involved in both detoxification reactions and biosyntheses, and hormone-mediated signaling processes function to coordinate the operation of energy-generating and energy-storing reactions and to couple these to other biosynthetic processes.

definition source

Reactome, http://www.reactome.org

label

Metabolism

located_in

http://purl.obolibrary.org/obo/NCBITaxon_9606

prefixIRI

HINO:0015266

prefLabel

Metabolism

seeAlso

ReactomeREACT_111217

GENE ONTOLOGYGO:0044281

Reactome Database ID Release 431430728

subClassOf

http://purl.obolibrary.org/obo/INO_0000021

has_part

http://purl.obolibrary.org/obo/HINO_0016373

http://purl.obolibrary.org/obo/HINO_0016370

http://purl.obolibrary.org/obo/HINO_0014489

http://purl.obolibrary.org/obo/HINO_0014453

http://purl.obolibrary.org/obo/HINO_0014396

http://purl.obolibrary.org/obo/HINO_0014160

http://purl.obolibrary.org/obo/HINO_0014191

http://purl.obolibrary.org/obo/HINO_0016319

http://purl.obolibrary.org/obo/HINO_0016318

http://purl.obolibrary.org/obo/HINO_0014566

http://purl.obolibrary.org/obo/HINO_0015268

http://purl.obolibrary.org/obo/HINO_0014521

http://purl.obolibrary.org/obo/HINO_0016394

http://purl.obolibrary.org/obo/HINO_0016390

http://purl.obolibrary.org/obo/HINO_0014509

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http://semanticscience.org/resource/SIO_010308 SIO LOOM
http://www.projecthalo.com/aura#Metabolism AURA LOOM
http://purl.jp/bio/4/id/200906000970502897 IOBC LOOM
https://w3id.org/skgo/modsci#Metabolism MODSCI LOOM
http://purl.obolibrary.org/obo/WC_metabolism WC LOOM
http://purl.bioontology.org/ontology/MESH/D008660 MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0025519 OCHV LOOM
http://purl.obolibrary.org/obo/MESH_D008660 BERO LOOM
http://purl.obolibrary.org/obo/UPa_UPA00026 UPA LOOM
http://purl.bioontology.org/ontology/MESH/Q000378 MESH LOOM
http://www.bioontology.org/pma.owl#PMA_938 PMA LOOM
http://www.semanticweb.org/rjyy/ontologies/2015/5/ESSO#Metabolism ESSO LOOM
http://www.semanticweb.org/rjyy/ontologies/2015/5/ESSO#Metabolism MEPO LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Metabolism APAONTO LOOM
http://radlex.org/RID/RID39130 RADLEX LOOM
http://www.owl-ontologies.com/unnamed.owl#Metabolism ADW LOOM
http://purl.obolibrary.org/obo/OMIT_0009723 OMIT LOOM
http://www.ifomis.org/acgt/1.0#Metabolism ACGT-MO LOOM
http://vocabs.lter-europe.net/EnvThes/21317 ENVTHES LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#G03.495 RH-MESH LOOM
http://purl.org/net/drug-interaction-knowledge-base/DIKB_evidence_ontology.owl#Metabolism DIKB LOOM
http://www.cea.fr/ontotoxnuc#Metabolisme ONTOTOXNUC LOOM
http://doe-generated-ontology.com/OntoAD#C0025519 ONTOAD LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D008660 RH-MESH LOOM
http://semanticscience.org/resource/SIO_010308 HHEARP LOOM
http://semanticscience.org/resource/SIO_010308 CHEAR LOOM
http://semanticscience.org/resource/SIO_010308 BIOMO LOOM
http://semanticscience.org/resource/SIO_010308 SCO LOOM
http://semanticscience.org/resource/SIO_010308 HHEAR LOOM
http://semanticscience.org/resource/SIO_010308 HASCO LOOM
http://vocabs.lter-europe.net/EnvThes/USLterCV_332 ENVTHES LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#7999 OCHV LOOM
http://purl.bioontology.org/ontology/CSP/1850-0312 CRISP LOOM
http://www.icn.ch/icnp#Metabolism ICNP LOOM
http://jermontology.org/ontology/JERMOntology#Metabolism JERM LOOM
http://localhost/plosthes.2017-1#7414 PLOSTHES LOOM
http://www.stanford.edu/~coulet/phare.owl#GeneProductMetabolism PHARE LOOM