loading...| Preferred Name |
Simvastatin |
| Definitions |
A derivative of lovastatin and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (hydroxymethylglutaryl COA reductases), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL receptors, it increases breakdown of LDL cholesterol. [Adapted from PubChem and DrugBank] |
| ID |
http://www.genomic-cds.org/ont/genomic-cds.owl#Simvastatin |
| comment |
A derivative of lovastatin and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (hydroxymethylglutaryl COA reductases), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL receptors, it increases breakdown of LDL cholesterol. [Adapted from PubChem and DrugBank] |
| label |
Simvastatin |
| prefixIRI |
Simvastatin |
| prefLabel |
Simvastatin |
| seeAlso | |
| subClassOf |