Fission Yeast Phenotype Ontology

Last uploaded: April 17, 2019
Preferred Name

pravastatin

Synonyms

424.52770

pravastatin acid

(3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid

C23H36O7

InChI=1S/C23H36O7/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28)/t13-,14-,16+,17+,18+,19-,20-,22-/m0/s1

pravastatine

TUZYXOIXSAXUGO-PZAWKZKUSA-N

pravastatinum

pravastatina

[H][C@]12[C@H](C[C@H](O)C=C1C=C[C@H](C)[C@@H]2CC[C@@H](O)C[C@@H](O)CC(O)=O)OC(=O)[C@@H](C)CC

(+)-(3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(S)-2-methylbutyryl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthyl]heptanoic acid

pravastatin

Definitions

A carboxylic ester resulting from the formal condensation of (S)-2-methylbutyric acid with the hydroxy group adjacent to the ring junction of (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. Derived from microbial transformation of mevastatin, pravastatin is a reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA). The sodium salt is used for lowering cholesterol and preventing cardiovascular disease. It is one of the lower potency statins, but has the advantage of fewer side effects compared with lovastatin and simvastatin.

ID

http://purl.obolibrary.org/obo/CHEBI_63618

database_cross_reference

KNApSAcK:C00000565

PMID:21749370

PMID:25264019

KEGG:C01844

KEGG:D08410

Wikipedia:Pravastatin

LINCS:LSM-3347

Reaxys:4825538

PMID:21851379

CAS:81093-37-0

HMDB:HMDB05022

DrugBank:DB00175

definition

A carboxylic ester resulting from the formal condensation of (S)-2-methylbutyric acid with the hydroxy group adjacent to the ring junction of (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. Derived from microbial transformation of mevastatin, pravastatin is a reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA). The sodium salt is used for lowering cholesterol and preventing cardiovascular disease. It is one of the lower potency statins, but has the advantage of fewer side effects compared with lovastatin and simvastatin.

has_alternative_id

CHEBI:8360

has_exact_synonym

(3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid

has_obo_namespace

chebi_ontology

has_related_synonym

424.52770

pravastatin acid

C23H36O7

InChI=1S/C23H36O7/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28)/t13-,14-,16+,17+,18+,19-,20-,22-/m0/s1

pravastatine

TUZYXOIXSAXUGO-PZAWKZKUSA-N

pravastatinum

pravastatina

[H][C@]12[C@H](C[C@H](O)C=C1C=C[C@H](C)[C@@H]2CC[C@@H](O)C[C@@H](O)CC(O)=O)OC(=O)[C@@H](C)CC

(+)-(3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(S)-2-methylbutyryl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthyl]heptanoic acid

pravastatin

IAO_0000412

http://purl.obolibrary.org/obo/chebi.owl

id

CHEBI:63618

label

pravastatin

notation

CHEBI:63618

prefLabel

pravastatin

subClassOf

http://purl.obolibrary.org/obo/CHEBI_33308

http://purl.obolibrary.org/obo/CHEBI_36785

http://purl.obolibrary.org/obo/CHEBI_61355

http://purl.obolibrary.org/obo/CHEBI_35868

http://purl.obolibrary.org/obo/CHEBI_35681

http://purl.obolibrary.org/obo/CHEBI_87633

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http://purl.jp/bio/4/id/200906093225057464 IOBC LOOM
http://purl.jp/bio/4/id/200906093225057464 IOBC LOOM
http://scai.fraunhofer.de/AlzheimerOntology#pravastatin ADO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148255 NDFRT LOOM
http://www.drugbank.ca/drugs/DB00175 FTC LOOM
http://purl.bioontology.org/ontology/LNC/LP171630-9 LOINC LOOM
http://purl.bioontology.org/ontology/UATC/C10AA03 ATC LOOM
http://purl.bioontology.org/ontology/NDDF/003606 NDDF LOOM
http://purl.bioontology.org/ontology/VANDF/4020548 VANDF LOOM
http://purl.bioontology.org/ontology/RCD/x01R3 RCD LOOM
http://d-nb.info/gnd/4255787-2 FAST-TOPICAL LOOM
http://www.co-ode.org/ontologies/galen#Pravastatin GALEN LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.559.847.638.930 RH-MESH LOOM
http://stirdf.jst.go.jp/id/200907020855913870 IOBC LOOM
http://www.semanticweb.org/ontologies/STO.owl#a5dcdea_0bdd_4060_bda4_ef53c4ecb067 CVAO LOOM
http://www.semanticweb.org/ontologies/STO.owl#a5dcdea_0bdd_4060_bda4_ef53c4ecb067 STO-DRAFT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.615.638.930 RH-MESH LOOM
http://doe-generated-ontology.com/OntoAD#C0085542 ONTOAD LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/373566006 SNOMEDCT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D017035 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/96305006 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/MESH/D017035 MESH LOOM
http://www.owl-ontologies.com/OntologyXCT.owl#Pravastatin CTX LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000424450 PDQ LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148255 ODAE LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148255 OCVDAE LOOM
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http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62070 NCIT LOOM
http://purl.bioontology.org/ontology/RXNORM/42463 RXNORM LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005336 FASTO LOOM
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