eNanoMapper

Last uploaded: July 12, 2023
Preferred Name

adverse event

Synonyms
Definitions

The OAE official website is: http://www.oae-ontology.org/. a pathological bodily process that occurs after a medical intervention. An adverse event is likely caused by the medical intervention; however, such a causal association is not required to be an adverse event.

ID

http://purl.obolibrary.org/obo/OAE_0000001

comment

The OAE official website is: http://www.oae-ontology.org/.

alternative term

adverse reaction

AE

editor note

YH: The current term 'adverse event' is different from the term definition shown in our paper: He Y, Xiang Z, Sarntivijai S, Toldo L, Ceusters W. OAE: a realism-based biomedical ontology for the representation of adverse events. Adverse Event Representation Workshop, International Conference on Biomedical Ontologies (ICBO), University at Buffalo, NY, July 26-30, 2011. Full lenghth conference proceeding paper. We made the name changing in order to make OAE cover the broader sense of the 'adverse event' which does not assume definite causal effect between an adverse event and a medical intervention. In current definition, the adverse event emphasizes the time association and assumes a likelihood of such a causal association. This term 'adverse event' is stil under the OGMS:pathological bodily process. The 'adverse event' defined in the above paper has now been changed to a new term: 'causal adverse event'. See more information in the new publication: Yongqun He Y, Sirarat Sarntivijai, Yu Lin, Zuoshuang Xiang, Abra Guo, Shelley Zhang, Desikan Jagannathan, Luca Toldo, Cui Tao and Barry Smith. OAE: The Ontology of Adverse Events. Journal of Biomedical Semantics. 2014, 5:29 doi:10.1186/2041-1480-5-29. PMID: 25093068.PMCID: PMC4120740.

YH: The main scope of OAE includes: (1) represent terms and relations in the area of adverse events, (2) assess possible associations between an adverse event and a medical intervention, particularly, identify any causal effect of a medical intervention to an adverse event; and (2) understand the mechanism (including molecular mechanisms) of causal adverse events.

YH: An adverse event is possibly induced by the medical intervention. It can be caused by the medical intervention, or may not be caused by the medical intervention. One ultimate goal (or the goal in clinics) of study adverse events is to assess if the adverse event outcome is due to the medical intervention.

YH: In development of OAE, we initially use vaccine adverse event as our use case. A vaccine adverse event is associated with a vaccination (i.e. a medical intervention), regardless of whether it is considered vaccine-related, and includes any side effect, injury, toxicity, or sensitivity reaction or significant failure of immunization (i.e., a pharmacologic action). Ref: Baylor NW and Midthum K. Regulation and testing of vaccines. In: Vaccines (Editors: Plotkin S, Orenstein W, and Offit P). 2008. p1623.

YH: There has been discussion regarding whether the term 'side effect' is an alternative term for 'adverse event'. In AERO, the term 'AERO:adverse event' represents a subset of those adverse events for which causality has been established. In OAE, an adverse event for which causality has been established is called 'causal adverse event'.

YH: An adverse event is a process that has specified output of some adverse medical outcome (e.g., symptom, sign or accident) after a medical intervention (or process) (e.g., administration of drug or vaccine). The medical intervention can be an administration of a drug, a vaccine (i.e., vaccination), or a special nutritional product (for example, dietary supplement, infant formula, medical food), surgery, or usage of a medical device.

Melanie Courtot and YH: More work is needed on how to restrict the scope of a term to be an 'adverse event', notably regarding temporal association. When is an appropirate time interval between a medical intervention and an adverse event observed? One week, one month, one year, or a lifetime? For some well-studied medical interventions (e.g., administration of many vaccines or drugs), we probably have a general idea. For many new interventions, we don't know much. In OAE, this issue is associated with defining the 'adverse event incubation time'.

label

adverse event

prefixIRI

OAE:0000001

prefLabel

adverse event

term editor

Yongqun He

定义来源

WEB: http://www.ncbi.nlm.nih.gov/pubmed/25093068

WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm

WEB: http://en.wikipedia.org/wiki/Adverse_event

文本定义

a pathological bodily process that occurs after a medical intervention. An adverse event is likely caused by the medical intervention; however, such a causal association is not required to be an adverse event.

subClassOf

http://purl.obolibrary.org/obo/BFO_0000015

Delete Subject Author Type Created
No notes to display
Create mapping

Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/OAE_0000001 OAE SAME_URI
http://purl.obolibrary.org/obo/OAE_0000001 PDRO SAME_URI
http://purl.obolibrary.org/obo/OAE_0000001 EUPATH SAME_URI
http://purl.obolibrary.org/obo/OAE_0000001 CTO SAME_URI
http://purl.obolibrary.org/obo/OAE_0000001 VICO SAME_URI
http://purl.obolibrary.org/obo/OAE_0000001 INBANCIDO SAME_URI
http://purl.obolibrary.org/obo/OAE_0000001 OVAE SAME_URI
http://purl.obolibrary.org/obo/OAE_0000001 OCMR SAME_URI
http://purl.obolibrary.org/obo/OAE_0000001 DINTO SAME_URI
http://purl.obolibrary.org/obo/OAE_0000001 OPMI SAME_URI
http://purl.obolibrary.org/obo/OAE_0000001 COVID-19 SAME_URI
http://purl.obolibrary.org/obo/OAE_0000001 EPIO SAME_URI
http://purl.obolibrary.org/obo/OAE_0000001 OLAM SAME_URI
http://purl.obolibrary.org/obo/OAE_0000001 GSSO SAME_URI
http://purl.obolibrary.org/obo/OAE_0000001 ODAE SAME_URI
http://purl.obolibrary.org/obo/OAE_0000001 CIDO SAME_URI
http://purl.obolibrary.org/obo/OAE_0000001 OCVDAE SAME_URI
http://purl.obolibrary.org/obo/OAE_0000001 DOVES SAME_URI
http://purl.obolibrary.org/obo/OAE_0000001 ICO SAME_URI
http://purl.obolibrary.org/obo/OAE_0000001 KTAO SAME_URI
http://purl.obolibrary.org/obo/OAE_0000001 MIDO SAME_URI
http://purl.obolibrary.org/obo/OAE_0000001 MELO SAME_URI
http://purl.obolibrary.org/obo/OAE_0000001 DIDEO SAME_URI
http://purl.obolibrary.org/obo/OAE_0000001 VO SAME_URI
http://purl.obolibrary.org/obo/OAE_0000001 ODNAE SAME_URI
http://purl.obolibrary.org/obo/OAE_0000001 OGSF SAME_URI
http://purl.bioontology.org/ontology/MEDDRA/10060933 MEDDRA LOOM
http://purl.bioontology.org/ontology/MEDDRA/10060933 NLN LOOM
http://www.semanticweb.org/ontologies/2012/0/Ontology1325521724189.owl#Adverse_events CTO-NDD LOOM
http://purl.bioontology.org/ontology/CMDO/CM0504 CMDO LOOM
http://doe-generated-ontology.com/OntoAD#C0877248 ONTOAD LOOM
http://purl.jp/bio/4/id/201506015651149055 IOBC LOOM
http://purl.obolibrary.org/obo/AERO_0000009 AERO LOOM
http://purl.obolibrary.org/obo/OAE_0000001 OAE LOOM
http://purl.obolibrary.org/obo/OAE_0000001 PDRO LOOM
http://purl.obolibrary.org/obo/OAE_0000001 EUPATH LOOM
http://purl.obolibrary.org/obo/OAE_0000001 CTO LOOM
http://purl.obolibrary.org/obo/OAE_0000001 VICO LOOM
http://purl.obolibrary.org/obo/OAE_0000001 INBANCIDO LOOM
http://purl.obolibrary.org/obo/OAE_0000001 OVAE LOOM
http://purl.obolibrary.org/obo/OAE_0000001 OCMR LOOM
http://purl.obolibrary.org/obo/OAE_0000001 OPMI LOOM
http://purl.obolibrary.org/obo/OAE_0000001 COVID-19 LOOM
http://purl.obolibrary.org/obo/OAE_0000001 EPIO LOOM
http://purl.obolibrary.org/obo/OAE_0000001 OLAM LOOM
http://purl.obolibrary.org/obo/OAE_0000001 GSSO LOOM
http://purl.obolibrary.org/obo/OAE_0000001 ODAE LOOM
http://purl.obolibrary.org/obo/OAE_0000001 CIDO LOOM
http://purl.obolibrary.org/obo/OAE_0000001 OCVDAE LOOM
http://purl.obolibrary.org/obo/OAE_0000001 ICO LOOM
http://purl.obolibrary.org/obo/OAE_0000001 KTAO LOOM
http://purl.obolibrary.org/obo/OAE_0000001 DIDEO LOOM
http://purl.obolibrary.org/obo/OAE_0000001 VO LOOM
http://purl.obolibrary.org/obo/OAE_0000001 ODNAE LOOM
http://purl.obolibrary.org/obo/OAE_0000001 OGSF LOOM
http://purl.bioontology.org/ontology/LNC/LP72057-0 LOINC LOOM
http://purl.obolibrary.org/obo/MVC_0000510 MIXSCV LOOM
http://www.semanticweb.org/ontologies/2012/0/Ontology1325521724189.owl#Adverse_Event_Sub-Domain CTO-NDD LOOM
https://contsys.org/concept/adverse_event CONTSONTO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0877248 OCHV LOOM
http://purl.bioontology.org/ontology/LNC/MTHU014542 LOINC LOOM
http://www.bridgmodel.org/owl#AdverseEvent BRIDG LOOM
http://purl.obolibrary.org/obo/NCIT_C41331 BERO LOOM
http://purl.bioontology.org/ontology/LNC/LA7266-5 LOINC LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C41331 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C41331 ROO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#51845 OCHV LOOM