loading...| Preferred Name |
Deferasirox |
|
| Synonyms |
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|
| Definitions |
A synthetic, orally bioavailable, achiral, tridentate triazole derived from salicylic acid with iron-chelating activity. Deferasirox chelates iron at a 2:1 (ligand:iron) ratio. Because of its oral availability and long plasma half-life, this agent may be superior to desferrioxamine (desferal, DFO), which is orally inactive and has a short plasma half-life. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48384 |
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| ALT_DEFINITION |
A drug used to treat too much iron in the blood caused by blood transfusions. It is being studied in the treatment of myelodysplastic syndromes (a group of diseases in which the bone marrow does not make enough healthy blood cells) and other conditions. Deferasirox binds to extra iron in the blood. The drug and the iron are passed from the body in urine. It is a type of chelating agent. |
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| CAS_Registry |
201530-41-8 |
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| CHEBI_ID |
CHEBI:49005 |
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| Chemical_Formula |
C21H15N3O4 |
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| code |
C48384 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
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| Contributing_Source |
CTRP FDA |
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| DEFINITION |
A synthetic, orally bioavailable, achiral, tridentate triazole derived from salicylic acid with iron-chelating activity. Deferasirox chelates iron at a 2:1 (ligand:iron) ratio. Because of its oral availability and long plasma half-life, this agent may be superior to desferrioxamine (desferal, DFO), which is orally inactive and has a short plasma half-life. |
|
| Display_Name |
Deferasirox |
|
| FDA_UNII_Code |
V8G4MOF2V9 |
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| FULL_SYN |
deferasirox 4-(3,5-Bis-(hydroxy-phenyl)-1,2,4-triazol-1-yl)-benzoic Acid DEFERASIROX Deferasirox Exjade |
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| Has_Target | ||
| label |
Deferasirox |
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| Legacy Concept Name |
Deferasirox |
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| NCI_Drug_Dictionary_ID |
435986 |
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| PDQ_Closed_Trial_Search_ID |
435986 |
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| PDQ_Open_Trial_Search_ID |
435986 |
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| Preferred_Name |
Deferasirox |
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| prefixIRI |
Thesaurus:C48384 |
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| prefLabel |
Deferasirox |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C1619629 |
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| 文本定义 |
A synthetic, orally bioavailable, achiral, tridentate triazole derived from salicylic acid with iron-chelating activity. Deferasirox chelates iron at a 2:1 (ligand:iron) ratio. Because of its oral availability and long plasma half-life, this agent may be superior to desferrioxamine (desferal, DFO), which is orally inactive and has a short plasma half-life. |
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| subClassOf |