loading...| Preferred Name |
motor neuron disease |
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| Synonyms |
ANTERIOR HORN CELL DIS Neuron Diseases, Motor SECOND MOTOR NEURON DIS MOTOR NEURON DIS LOWER UPPER MOTOR NEURON DIS Anterior Horn Cell Disease LOWER MOTOR NEURON DIS MOTOR NEURON DIS UPPER Scleroses, Lateral Familial Motor Neuron Disease Lateral Scleroses FAMILIAL MOTOR NEURON DIS Sclerosis, Lateral Motor Neuron Disease, Lower MOTOR NEURON DIS SECOND Motor Neuron Disease, Upper Motor Neuron Disease, Secondary MOTOR SYSTEM DIS Motor Neuron Diseases Neuron Disease, Motor Secondary Motor Neuron Disease Upper Motor Neuron Disease Lower Motor Neuron Disease MOTOR NEURON DIS FAMILIAL Lateral Sclerosis MOTOR NEURON DIS Motor Neuron Disease, Familial Motor System Disease Motor System Diseases Scleroses, Primary Lateral motor neuron disease or disorder anterior horn cell disease disorder of motor neuron motor neuron disease motor neuron disorder disease or disorder of motor neuron disease of motor neuron |
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| Definitions |
Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089) A disease involving the motor neuron. |
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| ID |
http://www.ebi.ac.uk/efo/EFO_0003782 |
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| closeMatch | ||
| database_cross_reference |
MeSH:D016472 SNOMEDCT:37340000 MedDRA:10028002 ICD9:335.2 Orphanet:98503 MedDRA:10028003 MONDO:0020128 DOID:231 ICD9:335.8 GARD:19477 SCTID:37340000 ICD9:335.9 ICD10CM:G12.2 MESH:D016472 |
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| definition |
Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089) A disease involving the motor neuron. |
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| disease has location | ||
| exactMatch |
http://purl.bioontology.org/ontology/ICD10CM/G12.2 http://identifiers.org/snomedct/37340000 http://purl.obolibrary.org/obo/Orphanet_98503 |
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| has_exact_synonym |
ANTERIOR HORN CELL DIS Neuron Diseases, Motor SECOND MOTOR NEURON DIS MOTOR NEURON DIS LOWER UPPER MOTOR NEURON DIS Anterior Horn Cell Disease LOWER MOTOR NEURON DIS MOTOR NEURON DIS UPPER Scleroses, Lateral Familial Motor Neuron Disease Lateral Scleroses FAMILIAL MOTOR NEURON DIS Sclerosis, Lateral Motor Neuron Disease, Lower MOTOR NEURON DIS SECOND Motor Neuron Disease, Upper Motor Neuron Disease, Secondary MOTOR SYSTEM DIS Motor Neuron Diseases Neuron Disease, Motor Secondary Motor Neuron Disease Upper Motor Neuron Disease Lower Motor Neuron Disease MOTOR NEURON DIS FAMILIAL Lateral Sclerosis MOTOR NEURON DIS Motor Neuron Disease, Familial Motor System Disease Motor System Diseases Scleroses, Primary Lateral motor neuron disease or disorder anterior horn cell disease disorder of motor neuron motor neuron disease motor neuron disorder disease or disorder of motor neuron disease of motor neuron |
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| id |
EFO:0003782 |
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| in_subset |
http://purl.obolibrary.org/obo/mondo#rare http://purl.obolibrary.org/obo/mondo#orphanet_rare http://purl.obolibrary.org/obo/mondo#gard_rare http://purl.obolibrary.org/obo/mondo#disease_grouping http://purl.obolibrary.org/obo/mondo#ordo_group_of_disorders |
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| label |
motor neuron disease |
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| notation |
EFO:0003782 |
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| prefLabel |
motor neuron disease |
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| term editor |
Tomasz Adamusiak |
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| subClassOf |
http://www.ebi.ac.uk/efo/EFO_0000408 |