Experimental Factor Ontology

Last uploaded: March 18, 2024
Preferred Name

microglial cell

Synonyms

hortega cells

microgliocyte

brain-resident macrophage

brain macrophage

MF.microglia.CNS

microglia

Definitions

Unlike macroglial cells, microglial cells arise from hematopoietic stem cells in the yolk sac during early embryogenesis that populate the central nervous system. They derive from embryonic mesoderm and are not from neuroectoderm where glioblast develops from. Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive. A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive.

ID

http://purl.obolibrary.org/obo/CL_0000129

comment

Unlike macroglial cells, microglial cells arise from hematopoietic stem cells in the yolk sac during early embryogenesis that populate the central nervous system. They derive from embryonic mesoderm and are not from neuroectoderm where glioblast develops from. Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive.

database_cross_reference

SNOMEDCT:63483002

NIFSTD:sao789292116

BTO:0000078

BTO:0000962

MeSH:D017628

NCIt:C12616

FMA:54539

definition

A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive.

has_broad_synonym

brain macrophage

has_exact_synonym

hortega cells

microgliocyte

brain-resident macrophage

has_related_synonym

MF.microglia.CNS

microglia

in_subset

http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas

http://purl.obolibrary.org/obo/cl#cellxgene_subset

label

microglial cell

located_in

http://purl.obolibrary.org/obo/UBERON_0001017

prefixIRI

CL:0000129

prefLabel

microglial cell

RO_0002175

http://purl.obolibrary.org/obo/NCBITaxon_9606

subClassOf

http://purl.obolibrary.org/obo/CL_0000125

http://purl.obolibrary.org/obo/CL_0000878

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/CL_0000129 OBA SAME_URI
http://purl.obolibrary.org/obo/CL_0000129 CL SAME_URI
http://purl.obolibrary.org/obo/CL_0000129 CLO SAME_URI
http://purl.obolibrary.org/obo/CL_0000129 AEO SAME_URI
http://purl.obolibrary.org/obo/CL_0000129 CHEAR SAME_URI
http://purl.obolibrary.org/obo/CL_0000129 NGBO SAME_URI
http://purl.obolibrary.org/obo/CL_0000129 PCL SAME_URI
http://purl.obolibrary.org/obo/CL_0000129 BERO SAME_URI
http://purl.obolibrary.org/obo/CL_0000129 HHEAR SAME_URI
http://purl.obolibrary.org/obo/CL_0000129 OBA SAME_URI
http://purl.obolibrary.org/obo/CL_0000129 UPHENO SAME_URI
http://purl.obolibrary.org/obo/CL_0000129 CCF SAME_URI
http://purl.obolibrary.org/obo/CL_0000129 EHDAA2 SAME_URI
http://purl.obolibrary.org/obo/CL_0000129 GO-PLUS SAME_URI
http://purl.obolibrary.org/obo/CL_0000129 OBA LOOM
http://purl.org/obo/owlapi/fma#FMA_54539 BIOMODELS LOOM
http://uri.neuinfo.org/nif/nifstd/sao789292116 NIFSTD LOOM
http://purl.obolibrary.org/obo/XAO_0005134 XPO LOOM
http://purl.obolibrary.org/obo/XAO_0005134 UPHENO LOOM
http://purl.obolibrary.org/obo/XAO_0005134 XAO LOOM
http://regenbase.org/ontology#RB_0000047 RB LOOM
http://purl.obolibrary.org/obo/CL_0000129 CL LOOM
http://purl.obolibrary.org/obo/CL_0000129 CLO LOOM
http://purl.obolibrary.org/obo/CL_0000129 AEO LOOM
http://purl.obolibrary.org/obo/CL_0000129 CHEAR LOOM
http://purl.obolibrary.org/obo/CL_0000129 NGBO LOOM
http://purl.obolibrary.org/obo/CL_0000129 PCL LOOM
http://purl.obolibrary.org/obo/CL_0000129 HHEAR LOOM
http://purl.obolibrary.org/obo/CL_0000129 OBA LOOM
http://purl.obolibrary.org/obo/CL_0000129 UPHENO LOOM
http://purl.obolibrary.org/obo/CL_0000129 CCF LOOM
http://purl.obolibrary.org/obo/CL_0000129 EHDAA2 LOOM
http://purl.obolibrary.org/obo/CL_0000129 GO-PLUS LOOM
http://purl.obolibrary.org/obo/TAO_0009077 TAO LOOM
http://purl.bioontology.org/ontology/MCCL/CL_0000129 SYN LOOM
http://ontology.neuinfo.org/NIF/BiomaterialEntities/NIF-Cell.owl#nifext_170 NIFCELL LOOM
http://purl.org/sig/ont/fma/fma54539 FMA LOOM
http://purl.obolibrary.org/obo/ZFA_0009077 ZFA LOOM
http://purl.obolibrary.org/obo/ZFA_0009077 UPHENO LOOM
http://purl.obolibrary.org/obo/ZFA_0009077 ZP LOOM
http://purl.org/obo/owl/CL#CL_0000129 BIOMODELS LOOM
http://ontology.neuinfo.org/NIF/BiomaterialEntities/NIF-Cell.owl#sao789292116 NIFCELL LOOM
http://uri.neuinfo.org/nif/nifstd/nifext_170 NIFSTD LOOM