Number of classes: | 10075 |
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Number of individuals: | 3 |
Number of properties: | 43 |
Maximum depth: | 11 |
Maximum number of children: | 1691 |
Average number of children: | 4 |
Classes with a single child: | 1278 |
Classes with more than 25 children: | 30 |
Classes with no definition: | 3290 |
Acronym | DTO |
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Visibility | Public |
BioPortal PURL | http://purl.bioontology.org/ontology/DTO |
Description | Drug Target Ontology (DTO) is being developed at the University of Miami in the research group of Stephan Schürer. DTO is supported by grant U54CA189205 (Illuminating the Druggable Genome Knowledge Management Center, Tudor Oprea, PI) awarded by the NCI through the NIH Common Fund. It is a component of the Illuminating the Druggable Genome (IDG) project (https://commonfund.nih.gov/idg). The DTO project develops a novel semantic framework to formalize knowledge about drug targets with a focus on the current IDG protein families. The DTO is developed as a reference for drug targets with the longer-term goal to create a community standard that will facilitate the integration of diverse drug discovery information from numerous heterogeneous resources. The first version of the DTO consists of asserted class hierarchies of the four IDG protein families, GPCRs, kinases, ion channels, and nuclear hormone receptors. Protein classes are linked to tissue and disease via different levels of confidence. DTO also contains drug target development level classifications developed in the IDG project (http://targetcentral.ws/), and functional and qualitative annotations and classifications for kinase proteins, GPCR ligands and ion channels. DTO is modeled in OWL2-DL to enable further classification by inference reasoning and SPARQL queries. DTO is implemented following a modularization approach. DTO is used as the organizational framework for drug targets in the IDG PHAROS User Interface Portal (https://pharos.nih.gov) and also the Tin-X Target Importance and Novelty Explorer (http://newdrugtargets.org). |
Status | Beta |
Format | OWL |
Contact | Stephan Schurer, sschurer@med.miami.edu |
Home Page | http://drugtargetontology.org/ |
Publications Page | http://drugtargetontology.org/ |
Documentation Page | http://drugtargetontology.org/ |
Categories | Chemical, Gene Product, Human, Molecule, Other, Protein |
Groups | |
License Information | This ontology is licensed under Creative Commons Attribution-ShareAlike 4.0 International. |
Submission | Release Date | Upload Date | Downloads |
---|---|---|---|
1.1.1 (Parsed, Indexed, Metrics, Annotator) | 02/15/2018 | 02/15/2018 | OWL | CSV | RDF/XML | Diff |
1.1 (Archived) | 12/07/2017 | 12/07/2017 | OWL | Diff |
1.1 (Archived) | 12/06/2017 | 12/06/2017 | OWL | Diff |
1.0 (Archived) | 07/20/2017 | 07/20/2017 | OWL | Diff |
1.0 (Archived) | 12/04/2015 | 12/04/2015 | OWL |
more... |
Project | Description | People | Institution |
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BioAssay Express
|
BioAssay Express allows to explore the similarity of assays...
BioAssay Express allows to explore the similarity of assays within and between organizations. browse and group assays based upon meaningful, detailed criteria like cell type, target, readouts, assay kit, etc., identify similar assays both early on for assay validation and later on for greater confidence in SAR (structure activity relationship). Common Assay Template, which draws from a number of underlying vocabularies created by domain experts, including the BioAssay Ontology (BAO), Drug Target Ontology (DTO), Cell Line Ontology (CLO) and others.
|
Alex M. Clark, Nadia K. Litterman, Janice E. Kranz, Peter Gund, Kellan Gregory, Barry A. Bunin
Alex M. Clark, Nadia K. Litterman, Janice E. Kranz, Peter Gund, Kellan Gregory, Barry A. Bunin
|
Collaborative Drug Discovery |
Drug Target Ontology
|
Drug Target Ontology (DTO) is being developed at the University...
Drug Target Ontology (DTO) is being developed at the University of Miami in the research group of Stephan Schürer. DTO is supported by grant U54CA189205 (Illuminating the Druggable Genome Knowledge Management Center, Tudor Oprea, PI) awarded by the NCI through the NIH Common Fund. It is a component of the Illuminating the Druggable Genome (IDG) project (https://commonfund.nih.gov/idg). The DTO project develops a novel semantic framework to formalize knowledge about drug targets with a focus on the current IDG protein families. The DTO is developed as a reference for drug targets with the longer-term goal to create a community standard that will facilitate the integration of diverse drug discovery information from numerous heterogeneous resources. The first version of the DTO consists of asserted class hierarchies of the four IDG protein families, GPCRs, kinases, ion channels, and nuclear hormone receptors. Protein classes are linked to tissue and disease via different levels of confidence. DTO also contains drug target development classifications, a large collection of cell lines from the LINCS project and relevant cell-disease and cell-tissue relations. DTO is modeled in OWL2-DL to enable further classification by inference reasoning and SPARQL queries. DTO is implemented following a modularization approach. DTO will serve as the organizational framework for drug targets in the IDG PHAROS User Interface Portal (https://pharos.nih.gov).
|
Stephan Schurer
Stephan Schurer
|
University of Miami |