The Drug Ontology

Last uploaded: March 3, 2024
Preferred Name

Misoprostol

Synonyms

Methyl (+-)-11-alpha,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oate

misoprostolum

(11-alpha,13E)-(+-)-11,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid methyl ester

misoprostol

(+-)-methyl (1R,2R,3R)-3-hydroxy-2-((E)-(4RS)-4-hydroxy-4-methyl-1-octenyl)-5-oxocyclopentaneheptanoate

Arthrotec

Cytotec

Definitions

A diastereoisomeric mixture composed of approximately equal amounts of a double racemate of four of the sixteen possible diastereoisomers of methyl (13E)-11,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oate that is racemic prostaglandin E1 which is lacking the hydroxy group at position 15, but which has an additional hydroxy group at position 16. It is a synthetic prostaglandin E1 analogue, used in the treatment of gastric and duodenal ulcers. A weak abortifacient, it is also used for cervical ripening prior to surgical termination of pregnancy. The (11R,16S)-diastereoisomer is the pharmacologically active form.

ID

http://purl.obolibrary.org/obo/CHEBI_63610

database_cross_reference

Patent:BE827127

CAS:59122-46-2

PMID:1417145

PMID:2109814

DrugBank:DB00929

KEGG:D00419

Patent:US3965143

PMID:3080288

PMID:11136959

Wikipedia:Misoprostol

PMID:18690850

PMID:19740175

Reaxys:4155643

PMID:10945193

PMID:10949752

definition

A diastereoisomeric mixture composed of approximately equal amounts of a double racemate of four of the sixteen possible diastereoisomers of methyl (13E)-11,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oate that is racemic prostaglandin E1 which is lacking the hydroxy group at position 15, but which has an additional hydroxy group at position 16. It is a synthetic prostaglandin E1 analogue, used in the treatment of gastric and duodenal ulcers. A weak abortifacient, it is also used for cervical ripening prior to surgical termination of pregnancy. The (11R,16S)-diastereoisomer is the pharmacologically active form.

has part

http://purl.obolibrary.org/obo/CHEBI_63700

http://purl.obolibrary.org/obo/CHEBI_63698

http://purl.obolibrary.org/obo/CHEBI_63695

http://purl.obolibrary.org/obo/CHEBI_63705

has role

http://purl.obolibrary.org/obo/CHEBI_49201

http://purl.obolibrary.org/obo/CHEBI_50691

http://purl.obolibrary.org/obo/CHEBI_36063

has_alternative_id

CHEBI:6952

has_obo_namespace

chebi_ontology

has_related_synonym

Methyl (+-)-11-alpha,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oate

misoprostolum

(11-alpha,13E)-(+-)-11,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid methyl ester

misoprostol

(+-)-methyl (1R,2R,3R)-3-hydroxy-2-((E)-(4RS)-4-hydroxy-4-methyl-1-octenyl)-5-oxocyclopentaneheptanoate

Arthrotec

Cytotec

has_RxCUI

42331

id

CHEBI:63610

in_subset

http://purl.obolibrary.org/obo/chebi#3_STAR

label

Misoprostol

misoprostol

notation

CHEBI:63610

prefLabel

Misoprostol

subClassOf

http://purl.obolibrary.org/obo/CHEBI_60915

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_63610 PDRO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_63610 DINTO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_63610 BERO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_63610 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_63610 ODNAE SAME_URI
http://www.drugbank.ca/drugs/DB00929 FTC LOOM
http://purl.bioontology.org/ontology/RXNORM/42331 RXNORM LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147506 NDFRT LOOM
http://www.gamuts.net/entity#misoprostol GAMUTS LOOM
http://purl.bioontology.org/ontology/MESH/D016595 MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4019313 VANDF LOOM
http://purl.bioontology.org/ontology/SNMI/C-84050 SNMI LOOM
http://www.co-ode.org/ontologies/galen#Misoprostol GALEN LOOM
http://purl.obolibrary.org/obo/CHEBI_63610 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_63610 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_63610 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_63610 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_63610 ODNAE LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D23.469.700.660.500 RH-MESH LOOM
https://go.drugbank.com/drugs/DB00929 MDM LOOM
http://purl.obolibrary.org/obo/MESH_D016595 BERO LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147506 ODAE LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387242007 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/NCIT_C1313 BERO LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000042872 PDQ LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0085174 OCHV LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#15479 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D10.251.355.255.550.700.450.500 RH-MESH LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1313 NCIT LOOM
http://purl.jp/bio/4/id/200906049538283512 IOBC LOOM
http://bmi.utah.edu/ontologies/peontology/C0085174 RAO LOOM
http://www.phoc.org.cn/pmo/class/PMO_00021141 PMAPP-PMO LOOM
http://stirdf.jst.go.jp/id/200907015058006294 IOBC LOOM
http://purl.bioontology.org/ontology/ATC/A02BB01 ATC LOOM
http://purl.obolibrary.org/obo/OMIT_0017065 OMIT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D016595 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDDF/001133 NDDF LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClassa1f815de_f3a2_4464_9577_5875ad0b3895 WWECA LOOM
http://purl.bioontology.org/ontology/ATC/G02AD06 ATC LOOM