The Drug Ontology

Last uploaded: February 15, 2019
Preferred Name

cefditoren

Synonyms

InChI=1S/C19H18N6O5S3/c1-8-11(33-7-21-8)4-3-9-5-31-17-13(16(27)25(17)14(9)18(28)29)23-15(26)12(24-30-2)10-6-32-19(20)22-10/h3-4,6-7,13,17H,5H2,1-2H3,(H2,20,22)(H,23,26)(H,28,29)/b4-3-,24-12-/t13-,17-/m1/s1

cefditoren

7beta-(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido-3-[(Z)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl]-3,4-didehydrocepham-4-carboxylic acid

[H][C@]12SCC(C=C/c3scnc3C)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\c1csc(N)n1)C(O)=O

(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-[(Z)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

InChIKey=KMIPKYQIOVAHOP-YLGJWRNMSA-N

C19H18N6O5S3

Definitions

A broad spectrum, third-generation cephalosporin antibiotic with (Z)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido groups at positions 3 and 7, respectively, of the cephem skeleton. Generally administered as its orally absorbed pivaloyloxymethyl ester prodrug, it is used for the treatment of mild to moderate infections caused by susceptible strains of microorganisms in acute bacterial exacerbation of chronic bronchitis, community-acquired pneumonia, pharyngitis/tonsillitis, and uncomplicated skin and skin-structure infections.

ID

http://purl.obolibrary.org/obo/CHEBI_59343

database_cross_reference

Patent:US4839650

Beilstein:8174297

DrugBank:DB01066

ChemIDplus:104145-95-1

KEGG DRUG:D07639

Patent:EP475610

has_exact_synonym

7beta-(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido-3-[(Z)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl]-3,4-didehydrocepham-4-carboxylic acid

(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-[(Z)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

has_related_synonym

InChI=1S/C19H18N6O5S3/c1-8-11(33-7-21-8)4-3-9-5-31-17-13(16(27)25(17)14(9)18(28)29)23-15(26)12(24-30-2)10-6-32-19(20)22-10/h3-4,6-7,13,17H,5H2,1-2H3,(H2,20,22)(H,23,26)(H,28,29)/b4-3-,24-12-/t13-,17-/m1/s1

cefditoren

[H][C@]12SCC(C=C/c3scnc3C)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\c1csc(N)n1)C(O)=O

InChIKey=KMIPKYQIOVAHOP-YLGJWRNMSA-N

C19H18N6O5S3

has_RxCUI

83682

id

CHEBI:59343

label

cefditoren

notation

CHEBI:59343

prefixIRI

CHEBI:59343

prefLabel

cefditoren

textual definition

A broad spectrum, third-generation cephalosporin antibiotic with (Z)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido groups at positions 3 and 7, respectively, of the cephem skeleton. Generally administered as its orally absorbed pivaloyloxymethyl ester prodrug, it is used for the treatment of mild to moderate infections caused by susceptible strains of microorganisms in acute bacterial exacerbation of chronic bronchitis, community-acquired pneumonia, pharyngitis/tonsillitis, and uncomplicated skin and skin-structure infections.

subClassOf

http://purl.obolibrary.org/obo/CHEBI_33575

http://purl.obolibrary.org/obo/CHEBI_23066

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http://purl.obolibrary.org/obo/ARO_3000649 ARO LOOM
http://purl.obolibrary.org/obo/ARO_3000649 ARO LOOM
http://purl.bioontology.org/ontology/MESH/C073460 MESH LOOM
http://purl.jp/bio/4/id/200906067639128915 IOBC LOOM
http://purl.jp/bio/4/id/200906067639128915 IOBC LOOM
http://purl.jp/bio/4/id/200906067639128915 IOBC LOOM
http://purl.jp/bio/4/id/200906067639128915 IOBC LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C72625 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C72625 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C72625 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C72625 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C72625 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C72625 NCIT LOOM
http://purl.obolibrary.org/obo/CHEBI_59343 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_59343 GENEPIO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_59343 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_59343 BIOMODELS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_59343 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_59343 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_59343 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_59343 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_59343 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_59343 GENEPIO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_59343 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_59343 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_59343 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_59343 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_59343 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_59343 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_59343 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_59343 DINTO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_59343 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_59343 GENEPIO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_59343 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_59343 GENEPIO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_59343 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_59343 CHEBI SAME_URI
http://purl.bioontology.org/ontology/SNOMEDCT/708598002 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/LNC/MTHU016669 LOINC LOOM
http://purl.bioontology.org/ontology/LNC/LP33348-1 LOINC LOOM
http://purl.bioontology.org/ontology/NDDF/009507 NDDF LOOM
http://purl.bioontology.org/ontology/RXNORM/83682 RXNORM LOOM
http://stirdf.jst.go.jp/id/200907015204427299 IOBC LOOM
http://stirdf.jst.go.jp/id/200907015204427299 IOBC LOOM
http://stirdf.jst.go.jp/id/200907015204427299 IOBC LOOM
http://stirdf.jst.go.jp/id/200907015204427299 IOBC LOOM
http://purl.bioontology.org/ontology/VANDF/4024247 VANDF LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000022252 NDFRT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C073460 RH-MESH LOOM
http://purl.bioontology.org/ontology/UATC/J01DD16 ATC LOOM