The Drug Ontology

Last uploaded: February 15, 2019
Preferred Name

Dutasteride

Synonyms

N-[2,5-bis(trifluoromethyl)phenyl]-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide

(5alpha,17beta)-N-(2,5-bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide

InChIKey=JWJOTENAMICLJG-QWBYCMEYSA-N

[H][C@@]12CC[C@@]3([H])[C@]4([H])CC[C@]([H])(C(=O)Nc5cc(ccc5C(F)(F)F)C(F)(F)F)[C@@]4(C)CC[C@]3([H])[C@@]1(C)C=CC(=O)N2

InChI=1S/C27H30F6N2O2/c1-24-11-9-17-15(4-8-21-25(17,2)12-10-22(36)35-21)16(24)6-7-19(24)23(37)34-20-13-14(26(28,29)30)3-5-18(20)27(31,32)33/h3,5,10,12-13,15-17,19,21H,4,6-9,11H2,1-2H3,(H,34,37)(H,35,36)/t15-,16-,17-,19+,21+,24-,25+/m0/s1

C27H30F6N2O2

alpha,alpha,alpha,alpha',alpha',alpha'-hexafluoro-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxy-2',5'-xylidide

Definitions

Finasteride in which the tert-butyl group is replaced by a 2,5-bis(trifluoromethyl)phenyl group. A synthetic 4-azasteroid, dutasteride is a selective inhibitor of both the type 1 and type 2 isoforms of steroid 5alpha-reductase, an intracellular enzyme that converts testosterone to 5alpha-dihydrotestosterone. Dutasteride is used for the treatment of symptomatic benign prostatic hyperplasia in men with an enlarged prostate gland.

ID

http://purl.obolibrary.org/obo/CHEBI_521033

database_cross_reference

KEGG DRUG:D03820

DrugBank:DB01126

Patent:WO9507927

ChEMBL:521033

ChemIDplus:164656-23-9

Beilstein:7401530

has_exact_synonym

N-[2,5-bis(trifluoromethyl)phenyl]-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide

has_related_synonym

(5alpha,17beta)-N-(2,5-bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide

InChIKey=JWJOTENAMICLJG-QWBYCMEYSA-N

[H][C@@]12CC[C@@]3([H])[C@]4([H])CC[C@]([H])(C(=O)Nc5cc(ccc5C(F)(F)F)C(F)(F)F)[C@@]4(C)CC[C@]3([H])[C@@]1(C)C=CC(=O)N2

InChI=1S/C27H30F6N2O2/c1-24-11-9-17-15(4-8-21-25(17,2)12-10-22(36)35-21)16(24)6-7-19(24)23(37)34-20-13-14(26(28,29)30)3-5-18(20)27(31,32)33/h3,5,10,12-13,15-17,19,21H,4,6-9,11H2,1-2H3,(H,34,37)(H,35,36)/t15-,16-,17-,19+,21+,24-,25+/m0/s1

C27H30F6N2O2

alpha,alpha,alpha,alpha',alpha',alpha'-hexafluoro-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxy-2',5'-xylidide

has_RxCUI

228790

id

CHEBI:521033

label

Dutasteride

dutasteride

notation

CHEBI:521033

prefixIRI

CHEBI:521033

prefLabel

Dutasteride

textual definition

Finasteride in which the tert-butyl group is replaced by a 2,5-bis(trifluoromethyl)phenyl group. A synthetic 4-azasteroid, dutasteride is a selective inhibitor of both the type 1 and type 2 isoforms of steroid 5alpha-reductase, an intracellular enzyme that converts testosterone to 5alpha-dihydrotestosterone. Dutasteride is used for the treatment of symptomatic benign prostatic hyperplasia in men with an enlarged prostate gland.

subClassOf

http://purl.obolibrary.org/obo/CHEBI_35726

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http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47503 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47503 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47503 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47503 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47503 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47503 NCIT LOOM
http://purl.bioontology.org/ontology/UATC/G04CB02 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C108373 RH-MESH LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004621 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004621 DMTO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148790 NDFRT LOOM
http://purl.jp/bio/4/id/200906017639116383 IOBC LOOM
http://purl.jp/bio/4/id/200906017639116383 IOBC LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000479183 PDQ LOOM
http://stirdf.jst.go.jp/id/200907068774861843 IOBC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/385570006 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/CHEBI_521033 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_521033 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_521033 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_521033 BIOMODELS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_521033 NBO LOOM
http://purl.obolibrary.org/obo/CHEBI_521033 NBO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_521033 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_521033 DINTO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_521033 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_521033 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_521033 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_521033 CHEBI SAME_URI
http://purl.bioontology.org/ontology/NDDF/009824 NDDF LOOM
http://purl.bioontology.org/ontology/MESH/D000068538 MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/385572003 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/VANDF/4021371 VANDF LOOM
http://purl.bioontology.org/ontology/RXNORM/228790 RXNORM LOOM
http://www.drugbank.ca/drugs/DB01126 FTC LOOM