The Drug Ontology

Last uploaded: March 3, 2024
Preferred Name

Cisplatin

Synonyms

(SP-4-2)-diamminedichloridoplatinum

cis-diamminedichloroplatinum(II)

cis-diamminedichloridoplatinum(II)

(SP-4-2)-diamminedichloroplatinum

Cisplatin

[PtCl2(NH3)2]

Peyrone's salt

cisplatinum

Lederplatin

cis-diammineplatinum(II) dichloride

cis-Diamminedichloroplatinum(II)

cis-diamminedichloroplatinum

cis-dichlorodiammineplatinum(II)

cis-[PtCl2(NH3)2]

Peyrone's chloride

Briplatin

CDDP

Cismaplat

Neoplatin

Platamine

Platinex

Platinol

Randa

cis-DDP

cis-platin

cisplatin

cisplatine

cisplatino

Definitions

A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).

ID

http://purl.obolibrary.org/obo/CHEBI_27899

charge

0

database_cross_reference

DrugBank:DB00515

Wikipedia:Cisplatin

PMID:18472761

KEGG:D00275

PMID:23604226

PMID:12537968

Gmelin:2519

PMID:23651576

PMID:28494534

PMID:12831510

Reaxys:11324567

MetaCyc:CPD0-1392

PMID:1855275

PMID:16327988

Patent:DE2318020

PMID:12935404

KEGG:C06911

PMID:23554447

CAS:15663-27-1

Patent:DE2329485

HMDB:HMDB0014656

PMID:10883661

MolBase:25

definition

A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).

formula

Cl2H6N2Pt

H6Cl2N2Pt

has role

http://purl.obolibrary.org/obo/CHEBI_47868

http://purl.obolibrary.org/obo/CHEBI_35610

http://purl.obolibrary.org/obo/CHEBI_50684

http://purl.obolibrary.org/obo/CHEBI_25435

http://purl.obolibrary.org/obo/CHEBI_173085

http://purl.obolibrary.org/obo/CHEBI_68495

http://purl.obolibrary.org/obo/CHEBI_61015

has_alternative_id

CHEBI:23314

CHEBI:3722

has_exact_synonym

(SP-4-2)-diamminedichloridoplatinum

cis-diamminedichloroplatinum(II)

cis-diamminedichloridoplatinum(II)

(SP-4-2)-diamminedichloroplatinum

Cisplatin

has_obo_namespace

chebi_ontology

has_related_synonym

[PtCl2(NH3)2]

Peyrone's salt

cisplatinum

Lederplatin

cis-diammineplatinum(II) dichloride

cis-Diamminedichloroplatinum(II)

cis-diamminedichloroplatinum

cis-dichlorodiammineplatinum(II)

cis-[PtCl2(NH3)2]

Peyrone's chloride

Briplatin

CDDP

Cismaplat

Neoplatin

Platamine

Platinex

Platinol

Randa

cis-DDP

cis-platin

cisplatin

cisplatine

cisplatino

has_RxCUI

2555

id

CHEBI:27899

in_subset

http://purl.obolibrary.org/obo/chebi#3_STAR

inchi

InChI=1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2

inchikey

LXZZYRPGZAFOLE-UHFFFAOYSA-L

label

Cisplatin

cisplatin

mass

300.04452

monoisotopicmass

298.95560

notation

CHEBI:27899

prefLabel

Cisplatin

smiles

[H][N]([H])([H])[Pt](Cl)(Cl)[N]([H])([H])[H]

subClassOf

http://purl.obolibrary.org/obo/CHEBI_51214

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http://purl.obolibrary.org/obo/CHEBI_27899 EFO LOOM
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http://purl.obolibrary.org/obo/CHEBI_27899 MCO LOOM
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http://phenomebrowser.net/ontologies/mesh/mesh.owl#D01.710.100 RH-MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4018139 VANDF LOOM
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http://www.stanford.edu/~coulet/phare.owl#Cisplatin PHARE LOOM
http://www.phoc.org.cn/pmo/class/PMO_00015526 PMAPP-PMO LOOM
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http://www.co-ode.org/ontologies/galen#Cisplatin GALEN LOOM
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http://purl.bioontology.org/ontology/LNC/MTHU060553 LOINC LOOM
http://purl.obolibrary.org/obo/MESH_D002945 BERO LOOM