Preferred Name |
Amifostine |
|
Synonyms |
S-{2-[(3-aminopropyl)amino]ethyl} dihydrogen thiophosphate Amifostine amifostinum Ethyol amifostina amifostine |
|
Definitions |
An organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy. |
|
ID |
http://purl.obolibrary.org/obo/CHEBI_2636 |
|
charge |
0 |
|
database_cross_reference |
PMID:11201306 Beilstein:2088122 CAS:20537-88-6 PMID:12005544 KEGG:C06819 PMID:21347716 PMID:8683243 PMID:22402174 PMID:22844290 PMID:14980067 PMID:12499421 PMID:18072151 PMID:17602063 PMID:15698860 PMID:22878481 PMID:11984063 Drug_Central:156 Wikipedia:Amifostine PMID:22989457 Patent:US3892824 PMID:23092832 PMID:15380592 PMID:22643562 PMID:22440042 PMID:11013273 PMID:21646919 PMID:22496587 PMID:19712749 HMDB:HMDB0015274 PMID:18549666 PMID:12561384 PMID:22885239 PMID:15875769 Reaxys:2088122 PMID:12751907 PMID:23401928 PMID:10553165 PMID:12433814 DrugBank:DB01143 PMID:16465691 PMID:23052919 PMID:22267539 PMID:23040218 LINCS:LSM-4721 PMID:20334641 PMID:10942928 PMID:22456378 PMID:8612469 |
|
definition |
An organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy. |
|
formula |
C5H15N2O3PS |
|
has functional parent | ||
has role |
http://purl.obolibrary.org/obo/CHEBI_22586 |
|
has_exact_synonym |
S-{2-[(3-aminopropyl)amino]ethyl} dihydrogen thiophosphate Amifostine |
|
has_obo_namespace |
chebi_ontology |
|
has_related_synonym |
amifostinum Ethyol amifostina amifostine |
|
has_RxCUI |
4126 |
|
id |
CHEBI:2636 |
|
in_subset | ||
inchi |
InChI=1S/C5H15N2O3PS/c6-2-1-3-7-4-5-12-11(8,9)10/h7H,1-6H2,(H2,8,9,10) |
|
inchikey |
JKOQGQFVAUAYPM-UHFFFAOYSA-N |
|
label |
Amifostine amifostine |
|
mass |
214.22404 |
|
monoisotopicmass |
214.05410 |
|
notation |
CHEBI:2636 |
|
prefLabel |
Amifostine |
|
smiles |
NCCCNCCSP(O)(O)=O |
|
subClassOf |