loading...| Preferred Name |
phosphonoformic acid |
|
| Synonyms |
PHOSPHONOFORMIC ACID dihydroxyphosphanecarboxylic acid oxide carboxyphosphonic acid phosphonomethanoic acid FOSCARNET Foscarmet Foscarnet foscarnet |
|
| Definitions |
Phosphoric acid in which one of the hydroxy groups is replaced by a carboxylic acid group. It is used as the trisodium salt as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_127780 |
|
| charge |
0 |
|
| database_cross_reference |
PMID:15182735 PMID:19213941 KNApSAcK:C00000800 PMID:11576919 DrugBank:DB00529 PMID:7518199 Reaxys:1756501 CAS:4428-95-9 KEGG:C06456 PMID:19288498 PMID:21566148 PMID:21056575 PMID:16858125 PDBeChem:PPF Drug_Central:1241 Wikipedia:Foscarnet HMDB:HMDB0014670 |
|
| definition |
Phosphoric acid in which one of the hydroxy groups is replaced by a carboxylic acid group. It is used as the trisodium salt as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity. |
|
| formula |
CH3O5P |
|
| has functional parent | ||
| has role |
http://purl.obolibrary.org/obo/CHEBI_53756 http://purl.obolibrary.org/obo/CHEBI_176497 |
|
| has_alternative_id |
CHEBI:45085 CHEBI:8158 |
|
| has_exact_synonym |
PHOSPHONOFORMIC ACID dihydroxyphosphanecarboxylic acid oxide |
|
| has_obo_namespace |
chebi_ontology |
|
| has_related_synonym |
carboxyphosphonic acid phosphonomethanoic acid FOSCARNET Foscarmet Foscarnet foscarnet |
|
| has_RxCUI |
33562 |
|
| id |
CHEBI:127780 |
|
| in_subset | ||
| inchi |
InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6) |
|
| inchikey |
ZJAOAACCNHFJAH-UHFFFAOYSA-N |
|
| is conjugate acid of | ||
| label |
phosphonoformic acid Foscarnet |
|
| mass |
126.00530 |
|
| monoisotopicmass |
125.97181 |
|
| notation |
CHEBI:127780 |
|
| prefLabel |
phosphonoformic acid |
|
| smiles |
OC(=O)P(O)(O)=O |
|
| subClassOf |
http://purl.obolibrary.org/obo/CHEBI_26069 |