The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

brentuximab vedotin

ID

http://purl.obolibrary.org/obo/dinto_DB08870

ATCCode

L01XC12

binds

http://purl.obolibrary.org/obo/dinto_2103

CASRN

914088-09-8

DBBrand

adcetris

DBSynonym

cac10-vcmmae

sgn-35

Definition

Brentuximag vedotin or Adcetris? is an antibody-drug conjugate that combines an anti-CD30 antibody and the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin lymphoma and systemic anaplastic large cell lymphoma. Brentuximag vedotin was approved in 2011, and in January 2012, the drug label was revised to include a boxed warning of progressive multifocal leukoencephalopathy and death following JC virus infection.

has pharmacological target

http://purl.obolibrary.org/obo/dinto_2103

inhibits

http://purl.obolibrary.org/obo/dinto_2990

http://purl.obolibrary.org/obo/dinto_0901

is metabolised by

http://purl.obolibrary.org/obo/dinto_2990

http://purl.obolibrary.org/obo/dinto_0901

is transported by

http://purl.obolibrary.org/obo/dinto_1440

label

brentuximab vedotin

may interact with

http://purl.obolibrary.org/obo/dinto_DB00337

http://purl.obolibrary.org/obo/CHEBI_61049

http://purl.obolibrary.org/obo/dinto_DB00108

http://purl.obolibrary.org/obo/dinto_DB00290

prefixIRI

obo2:dinto_DB08870

prefLabel

brentuximab vedotin

xref

Wikipedia:http://en.wikipedia.org/wiki/Brentuximab_vedotin

Drugs.com:http://www.drugs.com/mtm/brentuximab-vedotin.html

RxList:http://www.rxlist.com/adcetris-drug.htm

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

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http://purl.bioontology.org/ontology/MESH/C547738 MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/1147320 RXNORM LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000530758 PDQ LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66944 NCIT LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000183555 NDFRT LOOM
http://purl.obolibrary.org/obo/DRON_00020132 DRON LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/713395006 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/UATC/L01XC12 ATC LOOM
http://purl.bioontology.org/ontology/VANDF/4031047 VANDF LOOM
http://purl.bioontology.org/ontology/NDDF/013904 NDDF LOOM
http://purl.jp/bio/4/id/201206090882884997 IOBC LOOM