The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

golimumab

Synonyms
ID

http://purl.obolibrary.org/obo/dinto_DB06674

ATCCode

L04AB06

CASRN

476181-74-5

DBBrand

simponi?

DBSynonym

cnto 148

Definition

Golimumab is a human IgG1? monoclonal antibody derived from immunizing genetically engineered mice with human TNF?. Golimumab binds and inhibits soluble and transmembrane human TNF?. Increased TNF? is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate treatment in patients with moderate to severe active rheumatoid arthritis (RA), (ii) alone or as an adjunct to methotrexate treatment in patients with active psoriatic arthritis (PsA), (iii) as a single agent in patients with active ankylosing spondylitis (AS), and (iv) as a single agent in patients with moderate to severe ulcerative colitis (UC) who require chronic steroids or have experienced intolerance or only a partial response to previous medications. In the U.S. and Canada, golimumab is marketed under the brand name Simponi?. The FDA label includes a black box warning of serious infections and malignancy. Additionally in children and adolescents taking golimumab, there have been lymphoma and other malignancies observed.

has pharmacological target

http://purl.obolibrary.org/obo/dinto_3490

label

golimumab

may interact with

http://purl.obolibrary.org/obo/dinto_DB00108

http://purl.obolibrary.org/obo/dinto_DB08879

http://purl.obolibrary.org/obo/CHEBI_61049

http://purl.obolibrary.org/obo/dinto_DB08904

http://purl.obolibrary.org/obo/dinto_DB00065

http://purl.obolibrary.org/obo/dinto_DB06372

http://purl.obolibrary.org/obo/dinto_DB00026

http://purl.obolibrary.org/obo/dinto_DB06168

http://purl.obolibrary.org/obo/dinto_DB01281

http://purl.obolibrary.org/obo/dinto_DB06273

http://purl.obolibrary.org/obo/dinto_DB00337

prefixIRI

obo2:dinto_DB06674

prefLabel

golimumab

related with

http://purl.obolibrary.org/obo/dinto_3490

xref

Drugs.com:http://www.drugs.com/mtm/golimumab.html

Wikipedia:http://en.wikipedia.org/wiki/Golimumab

RxList:http://www.rxlist.com/simponi-drug.htm

National Drug Code Directory:57894-071-01

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

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Delete Mapping To Ontology Source
https://github.com/sap218/coid/blob/master/coid.owl#COID_00479 COID LOOM
http://purl.bioontology.org/ontology/LNC/LP250855-6 LOINC LOOM
http://purl.bioontology.org/ontology/NDDF/013091 NDDF LOOM
http://purl.obolibrary.org/obo/DRON_00019225 PDRO LOOM
http://purl.obolibrary.org/obo/DRON_00019225 DRON LOOM
http://purl.obolibrary.org/obo/DRON_00019225 ODNAE LOOM
https://go.drugbank.com/drugs/DB06674 MDM LOOM
http://www.drugbank.ca/drugs/DB06674 FTC LOOM
http://purl.bioontology.org/ontology/MESH/C529000 MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/442435002 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/NCIT_C87766 BERO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000178413 NDFRT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C529000 RH-MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4028717 VANDF LOOM
http://purl.jp/bio/4/id/200906049036840116 IOBC LOOM
http://purl.bioontology.org/ontology/RXNORM/819300 RXNORM LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000791699 PDQ LOOM
https://github.com/sap218/ocimido/blob/master/ontology/ocimido.owl#OCIMIDO_00024 OCIMIDO LOOM
http://bmi.utah.edu/ontologies/peontology/C2353893 RAO LOOM
http://purl.bioontology.org/ontology/ATC/L04AB06 ATC LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000178413 ODAE LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026132 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/LNC/MTHU057588 LOINC LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C87766 NCIT LOOM