The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

eltrombopag

Synonyms

C25H22N4O4

3-(3-{2-[(4Z)-1-(3,4-dimethylphenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-ylidene]hydrazin-1-yl}-2-hydroxyphenyl)benzoic acid

ID

http://purl.obolibrary.org/obo/dinto_DB06210

activates

http://purl.obolibrary.org/obo/dinto_2137

AHFScode

20:16

ATCCode

B02BX05

CASRN

496775-61-2

DBBrand

promacta

revolade

DBSalt

eltrombopag olamine

DBSynonym

eltrombopagum

3'-{(2z)-2-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4h-pyrazol-4-ylidene]hydrazino}-2'-hydroxy-3-biphenylcarboxylic acid

sb 497115

Definition

Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelets in the blood. Eltrombopag has also been recently approved (late 2012) for the treatment of thrombocytopenia (low blood platelet counts) in patients with chronic hepatitis C to allow them to initiate and maintain interferon-based therapy.

InChI

InChI=1S/C25H22N4O4/c1-14-10-11-19(12-15(14)2)29-24(31)22(16(3)28-29)27-26-21-9-5-8-20(23(21)30)17-6-4-7-18(13-17)25(32)33/h4-13,26,30H,1-3H3,(H,32,33)/b27-22-

InChIKey

InChIKey=XDXWLKQMMKQXPV-QYQHSDTDSA-N

inhibits

http://purl.obolibrary.org/obo/dinto_2651

http://purl.obolibrary.org/obo/dinto_2019

http://purl.obolibrary.org/obo/dinto_1221

is metabolised by

http://purl.obolibrary.org/obo/dinto_2651

http://purl.obolibrary.org/obo/dinto_1892

http://purl.obolibrary.org/obo/dinto_1221

http://purl.obolibrary.org/obo/dinto_0276

label

eltrombopag

may interact with

http://purl.obolibrary.org/obo/CHEBI_119486

http://purl.obolibrary.org/obo/CHEBI_5004

http://purl.obolibrary.org/obo/CHEBI_102524

http://purl.obolibrary.org/obo/CHEBI_157175

http://purl.obolibrary.org/obo/CHEBI_39867

http://purl.obolibrary.org/obo/CHEBI_37924

http://purl.obolibrary.org/obo/CHEBI_44185

http://purl.obolibrary.org/obo/CHEBI_49662

http://purl.obolibrary.org/obo/CHEBI_101278

http://purl.obolibrary.org/obo/CHEBI_9927

http://purl.obolibrary.org/obo/CHEBI_17303

http://purl.obolibrary.org/obo/dinto_DB00893

http://purl.obolibrary.org/obo/CHEBI_15365

http://purl.obolibrary.org/obo/CHEBI_3699

http://purl.obolibrary.org/obo/CHEBI_41423

http://purl.obolibrary.org/obo/dinto_DB00258

http://purl.obolibrary.org/obo/CHEBI_240107

http://purl.obolibrary.org/obo/CHEBI_39669

http://purl.obolibrary.org/obo/CHEBI_32599

http://purl.obolibrary.org/obo/CHEBI_5855

http://purl.obolibrary.org/obo/dinto_DB00454

http://purl.obolibrary.org/obo/dinto_DB00854

http://purl.obolibrary.org/obo/dinto_DB00237

http://purl.obolibrary.org/obo/dinto_DB00365

http://purl.obolibrary.org/obo/CHEBI_15367

http://purl.obolibrary.org/obo/CHEBI_6916

http://purl.obolibrary.org/obo/CHEBI_100241

http://purl.obolibrary.org/obo/dinto_DB01110

http://purl.obolibrary.org/obo/CHEBI_5130

http://purl.obolibrary.org/obo/CHEBI_5138

http://purl.obolibrary.org/obo/CHEBI_5136

http://purl.obolibrary.org/obo/CHEBI_3387

http://purl.obolibrary.org/obo/CHEBI_10112

http://purl.obolibrary.org/obo/CHEBI_5779

http://purl.obolibrary.org/obo/dinto_DB00939

http://purl.obolibrary.org/obo/dinto_DB04272

http://purl.obolibrary.org/obo/CHEBI_5790

http://purl.obolibrary.org/obo/CHEBI_39548

http://purl.obolibrary.org/obo/CHEBI_6807

http://purl.obolibrary.org/obo/dinto_DB00784

http://purl.obolibrary.org/obo/CHEBI_4909

http://purl.obolibrary.org/obo/dinto_DB01351

http://purl.obolibrary.org/obo/dinto_DB06723

http://purl.obolibrary.org/obo/dinto_DB00814

http://purl.obolibrary.org/obo/dinto_DB00971

http://purl.obolibrary.org/obo/dinto_DB01118

http://purl.obolibrary.org/obo/dinto_DB01164

http://purl.obolibrary.org/obo/dinto_DB00199

http://purl.obolibrary.org/obo/dinto_DB00465

http://purl.obolibrary.org/obo/dinto_DB00977

http://purl.obolibrary.org/obo/CHEBI_6128

http://purl.obolibrary.org/obo/CHEBI_3311

http://purl.obolibrary.org/obo/CHEBI_119915

http://purl.obolibrary.org/obo/CHEBI_32139

http://purl.obolibrary.org/obo/CHEBI_47381

http://purl.obolibrary.org/obo/dinto_DB00951

http://purl.obolibrary.org/obo/CHEBI_46195

http://purl.obolibrary.org/obo/CHEBI_6402

prefixIRI

obo2:dinto_DB06210

prefLabel

eltrombopag

SMILES

CC1=NN(C(=O)\C1=N/NC1=C(O)C(=CC=C1)C1=CC=CC(=C1)C(O)=O)C1=CC=C(C)C(C)=C1

Synonym

C25H22N4O4

3-(3-{2-[(4Z)-1-(3,4-dimethylphenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-ylidene]hydrazin-1-yl}-2-hydroxyphenyl)benzoic acid

xref

RxList:http://www.rxlist.com/promacta-drug.htm

Drugs.com:http://www.drugs.com/ppa/eltrombopag.html

Wikipedia:http://en.wikipedia.org/wiki/Eltrombopag

National Drug Code Directory:0007-4640-13

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_85010 HOIP LOOM
http://purl.obolibrary.org/obo/CHEBI_85010 CHEBI LOOM
http://purl.bioontology.org/ontology/MESH/C520809 MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/711942 RXNORM LOOM
http://purl.obolibrary.org/obo/NCIT_C71634 BERO LOOM
http://purl.bioontology.org/ontology/ATC/B02BX05 ATC LOOM
http://purl.obolibrary.org/obo/DRON_00019163 INBANCIDO LOOM
http://purl.obolibrary.org/obo/DRON_00019163 CIDO LOOM
http://purl.obolibrary.org/obo/CHEBI_85010 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_85010 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_85010 INBANCIDO LOOM
http://purl.obolibrary.org/obo/CHEBI_85010 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_85010 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_85010 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_85010 CIDO LOOM
http://www.drugbank.ca/drugs/DB06210 FTC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000177933 NDFRT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C71634 NCIT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/432005001 SNOMEDCT LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000177933 INBANCIDO LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000177933 CIDO LOOM
http://purl.bioontology.org/ontology/NDDF/012912 NDDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C520809 RH-MESH LOOM
https://go.drugbank.com/drugs/DB06210 MDM LOOM
http://purl.bioontology.org/ontology/VANDF/4028105 VANDF LOOM
http://www.phoc.org.cn/pmo/class/PMO_00025378 PMAPP-PMO LOOM