The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

romiplostim

ID

http://purl.obolibrary.org/obo/dinto_DB05332

activates

http://purl.obolibrary.org/obo/dinto_2137

ATCCode

B02BX04

CASRN

267639-76-9

DBBrand

nplate

DBSynonym

amg 531

Definition

Romiplostim is a thrombopoiesis stimulating dimer Fc-peptide fusion protein (peptibody) to increase platelet production through activation of the thrombopoietin receptor. The peptibody molecule has two identical single-chain subunits, each one is made up of 269 amino acid residues. Each subunit consists of an IgG1 Fc carrier domain that is covalently attached to a polypeptide sequence that contains two binding domains to interact with thrombopoietin receptor c-Mpl. Each domain consists of 14 amino acids. Interestingly, romiplostim s amino acid sequence is not similar to that of endogenous thrombopoietin. Romiplostim is produced by recombinant DNA technology in Escherichia coli. FDA approved on August 22, 2008.

has pharmacological target

http://purl.obolibrary.org/obo/dinto_2137

label

romiplostim

prefixIRI

obo2:dinto_DB05332

prefLabel

romiplostim

xref

Drugs.com:http://www.drugs.com/monograph/romiplostim.html

National Drug Code Directory:55513-221-01

RxList:http://www.rxlist.com/nplate-drug.htm

Wikipedia:http://en.wikipedia.org/wiki/Romiplostim

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

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