The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

romiplostim

ID

http://purl.obolibrary.org/obo/dinto_DB05332

activates

http://purl.obolibrary.org/obo/dinto_2137

ATCCode

B02BX04

CASRN

267639-76-9

DBBrand

nplate

DBSynonym

amg 531

Definition

Romiplostim is a thrombopoiesis stimulating dimer Fc-peptide fusion protein (peptibody) to increase platelet production through activation of the thrombopoietin receptor. The peptibody molecule has two identical single-chain subunits, each one is made up of 269 amino acid residues. Each subunit consists of an IgG1 Fc carrier domain that is covalently attached to a polypeptide sequence that contains two binding domains to interact with thrombopoietin receptor c-Mpl. Each domain consists of 14 amino acids. Interestingly, romiplostim s amino acid sequence is not similar to that of endogenous thrombopoietin. Romiplostim is produced by recombinant DNA technology in Escherichia coli. FDA approved on August 22, 2008.

has pharmacological target

http://purl.obolibrary.org/obo/dinto_2137

label

romiplostim

prefixIRI

obo2:dinto_DB05332

prefLabel

romiplostim

xref

Drugs.com:http://www.drugs.com/monograph/romiplostim.html

National Drug Code Directory:55513-221-01

RxList:http://www.rxlist.com/nplate-drug.htm

Wikipedia:http://en.wikipedia.org/wiki/Romiplostim

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

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http://purl.bioontology.org/ontology/RXNORM/805452 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C488777 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000177934 NDFRT LOOM
http://purl.bioontology.org/ontology/VANDF/4028106 VANDF LOOM
http://purl.obolibrary.org/obo/DRON_00019123 DRON LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/439122000 SNOMEDCT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52183 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52183 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52183 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52183 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52183 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52183 NCIT LOOM
http://www.drugbank.ca/drugs/DB05332 FTC LOOM
http://purl.bioontology.org/ontology/NDDF/012794 NDDF LOOM
http://purl.bioontology.org/ontology/MESH/C488777 MESH LOOM
http://purl.jp/bio/4/id/201206025351381390 IOBC LOOM
http://purl.jp/bio/4/id/201206025351381390 IOBC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/441077008 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/UATC/B02BX04 ATC LOOM