romiplostim

http://purl.obolibrary.org/obo/dinto_DB05332

http://purl.obolibrary.org/obo/dinto_2137

B02BX04

267639-76-9

nplate

amg 531

Romiplostim is a thrombopoiesis stimulating dimer Fc-peptide fusion protein (peptibody) to increase platelet production through activation of the thrombopoietin receptor. The peptibody molecule has two identical single-chain subunits, each one is made up of 269 amino acid residues. Each subunit consists of an IgG1 Fc carrier domain that is covalently attached to a polypeptide sequence that contains two binding domains to interact with thrombopoietin receptor c-Mpl. Each domain consists of 14 amino acids. Interestingly, romiplostim s amino acid sequence is not similar to that of endogenous thrombopoietin. Romiplostim is produced by recombinant DNA technology in Escherichia coli. FDA approved on August 22, 2008.

http://purl.obolibrary.org/obo/dinto_2137

romiplostim

obo2:dinto_DB05332

romiplostim

Wikipedia:http://en.wikipedia.org/wiki/Romiplostim

National Drug Code Directory:55513-221-01

Drugs.com:http://www.drugs.com/monograph/romiplostim.html

RxList:http://www.rxlist.com/nplate-drug.htm

http://purl.obolibrary.org/obo/dinto_000055