loading...| Preferred Name |
molindone |
|
| Synonyms |
C16H24N2O2 3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)-4,5,6,7-tetrahydro-1H-indol-4-one |
|
| ID |
http://purl.obolibrary.org/obo/dinto_DB01618 |
|
| ATCCode |
N05AE02 |
|
| blocks |
http://purl.obolibrary.org/obo/dinto_2804 |
|
| CASRN |
7416-34-4 |
|
| DBBrand |
moban |
|
| DBSynonym |
molindona [inn-spanish] (+-)-molindone molindonum [inn-latin] |
|
| Definition |
An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to moderate affinity for cholinergic and alpha-adrenergic receptors. Some electrophysiologic data from animals indicate that molindone has certain characteristics that resemble those of clozapine. (From AMA Drug Evaluations Annual, 1994, p283) |
|
| has effect |
http://purl.obolibrary.org/obo/OAE_0000597 http://purl.obolibrary.org/obo/OAE_0000492 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0001489 http://purl.obolibrary.org/obo/OAE_0000365 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0001515 http://purl.obolibrary.org/obo/OAE_0000309 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000275 |
|
| has pharmacological target | ||
| InChI |
InChI=1S/C16H24N2O2/c1-3-13-11(2)17-14-5-4-12(16(19)15(13)14)10-18-6-8-20-9-7-18/h12,17H,3-10H2,1-2H3 |
|
| InChIKey |
InChIKey=KLPWJLBORRMFGK-UHFFFAOYSA-N |
|
| label |
molindone |
|
| may interact with |
http://purl.obolibrary.org/obo/CHEBI_42944 http://purl.obolibrary.org/obo/dinto_DB00209 http://purl.obolibrary.org/obo/CHEBI_53289 http://purl.obolibrary.org/obo/dinto_DB00427 http://purl.obolibrary.org/obo/CHEBI_27796 |
|
| prefixIRI |
obo2:dinto_DB01618 |
|
| prefLabel |
molindone |
|
| related with | ||
| SMILES |
CCC1=C(C)NC2=C1C(=O)C(CN1CCOCC1)CC2 |
|
| Synonym |
C16H24N2O2 3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)-4,5,6,7-tetrahydro-1H-indol-4-one |
|
| xref |
BindingDB:50130290 IUPHAR:207 PubChem Compound:23897 PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/mob1614.shtml National Drug Code Directory:63481-072-70 PharmGKB:PA164746756 ChemSpider:22342 Wikipedia:http://en.wikipedia.org/wiki/Molindone Guide To Pharmacology:207 Drugs.com:http://www.drugs.com/cdi/molindone.html RxList:http://www.rxlist.com/cgi/generic/molindone.htm PubChem Substance:46504744 |
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| subClassOf |