The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
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Preferred Name

lopinavir
Synonyms

C37H48N4O5

(2S)-N-[(2S,4S,5S)-5-[2-(2,6-dimethylphenoxy)acetamido]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide
ID

http://purl.obolibrary.org/obo/dinto_DB01601
ATCCode

J05AR10
CASRN

192725-17-0
DBBrand

aluviran

koletra
DBSynonym

lpv

abt-378
Definition

Lopinavir (ABT-378) is an antiretroviral of the protease inhibitor class. It is marketed by Abbott as Kaletra, a co-formulation with a sub-therapeutic dose of ritonavir, as a component of combination therapy to treat HIV/AIDS.
has pharmacological target

http://purl.obolibrary.org/obo/dinto_3326
InChI

InChI=1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34-/m0/s1
InChIKey

InChIKey=KJHKTHWMRKYKJE-SUGCFTRWSA-N
induces

http://purl.obolibrary.org/obo/dinto_0291
inhibits

http://purl.obolibrary.org/obo/dinto_2651

http://purl.obolibrary.org/obo/dinto_2058

http://purl.obolibrary.org/obo/dinto_2993

http://purl.obolibrary.org/obo/dinto_3326

http://purl.obolibrary.org/obo/dinto_0291

http://purl.obolibrary.org/obo/dinto_0901

http://purl.obolibrary.org/obo/dinto_1440

http://purl.obolibrary.org/obo/dinto_0465
is metabolised by

http://purl.obolibrary.org/obo/dinto_0901
label

lopinavir
may interact with

http://purl.obolibrary.org/obo/dinto_DB00906

http://purl.obolibrary.org/obo/CHEBI_32250

http://purl.obolibrary.org/obo/CHEBI_9948

http://purl.obolibrary.org/obo/CHEBI_9943

http://purl.obolibrary.org/obo/CHEBI_8107

http://purl.obolibrary.org/obo/CHEBI_4317

http://purl.obolibrary.org/obo/CHEBI_71940

http://purl.obolibrary.org/obo/CHEBI_41774

http://purl.obolibrary.org/obo/dinto_DB00541

http://purl.obolibrary.org/obo/CHEBI_10127

http://purl.obolibrary.org/obo/CHEBI_61049

http://purl.obolibrary.org/obo/dinto_DB00726

http://purl.obolibrary.org/obo/dinto_DB06287

http://purl.obolibrary.org/obo/CHEBI_63632

http://purl.obolibrary.org/obo/CHEBI_51364

http://purl.obolibrary.org/obo/dinto_DB00570

http://purl.obolibrary.org/obo/CHEBI_47657

http://purl.obolibrary.org/obo/CHEBI_10125

http://purl.obolibrary.org/obo/CHEBI_9654

http://purl.obolibrary.org/obo/dinto_DB00582

http://purl.obolibrary.org/obo/dinto_DB01558

http://purl.obolibrary.org/obo/CHEBI_32020

http://purl.obolibrary.org/obo/CHEBI_75988

http://purl.obolibrary.org/obo/dinto_DB08901

http://purl.obolibrary.org/obo/CHEBI_480999

http://purl.obolibrary.org/obo/CHEBI_9622

http://purl.obolibrary.org/obo/CHEBI_9398

http://purl.obolibrary.org/obo/CHEBI_32315

http://purl.obolibrary.org/obo/CHEBI_63628

http://purl.obolibrary.org/obo/CHEBI_421707

http://purl.obolibrary.org/obo/dinto_DB01320

http://purl.obolibrary.org/obo/CHEBI_367163

http://purl.obolibrary.org/obo/CHEBI_46295

http://purl.obolibrary.org/obo/dinto_DB00976
prefixIRI

obo2:dinto_DB01601
prefLabel

lopinavir
SMILES

CC(C)[C@H](N1CCCNC1=O)C(=O)N[C@H](C[C@H](O)[C@H](CC1=CC=CC=C1)NC(=O)COC1=C(C)C=CC=C1C)CC1=CC=CC=C1
Synonym

C37H48N4O5

(2S)-N-[(2S,4S,5S)-5-[2-(2,6-dimethylphenoxy)acetamido]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide
xref

Wikipedia:http://en.wikipedia.org/wiki/Lopinavir

PubChem Substance:46508588

ChemSpider:83706

PubChem Compound:92727

PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/kal1581.shtml

PharmGKB:PA450264

PDB:AB1

BindingDB:578

Drugs Product Database (DPD):2243643

RxList:http://www.rxlist.com/cgi/generic/kaletracaps.htm
subClassOf

http://purl.obolibrary.org/obo/dinto_000055
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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/XCO_0001172 XCO LOOM
http://purl.obolibrary.org/obo/CHEBI_31781 HOIP LOOM
http://purl.obolibrary.org/obo/CHEBI_31781 CHEBI LOOM
http://purl.bioontology.org/ontology/VANDF/4021228 VANDF LOOM
http://purl.bioontology.org/ontology/LNC/LP28756-2 LOINC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148672 NDFRT LOOM
http://purl.bioontology.org/ontology/NDDF/008874 NDDF LOOM
https://go.drugbank.com/drugs/DB01601 MDM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D061466 RH-MESH LOOM
http://scai.fraunhofer.de/HuPSON#SCAIVPH_00001129 HUPSON LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148672 INBANCIDO LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148672 CIDO LOOM
http://purl.obolibrary.org/obo/NCIT_C2095 BERO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#42574 OCHV LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0674432 OCHV LOOM
http://purl.obolibrary.org/obo/MESH_D061466 BERO LOOM
http://purl.obolibrary.org/obo/DRON_00016421 INBANCIDO LOOM
http://purl.obolibrary.org/obo/DRON_00016421 CIDO LOOM
http://purl.bioontology.org/ontology/MESH/D061466 MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387067003 SNOMEDCT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2095 NCIT LOOM
http://purl.obolibrary.org/obo/CHEBI_31781 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_31781 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_31781 INBANCIDO LOOM
http://purl.obolibrary.org/obo/CHEBI_31781 COVID-19 LOOM
http://purl.obolibrary.org/obo/CHEBI_31781 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_31781 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_31781 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_31781 CIDO LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018468 PMAPP-PMO LOOM
http://purl.obolibrary.org/obo/OMIT_0027975 OMIT LOOM
http://purl.bioontology.org/ontology/LNC/MTHU014678 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.742.698.553 RH-MESH LOOM
http://purl.bioontology.org/ontology/CSP/5006-0022 CRISP LOOM
http://purl.bioontology.org/ontology/RXNORM/195088 RXNORM LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000540623 PDQ LOOM