loading...| Preferred Name |
salsalate |
|
| Synonyms |
C14H10O5 2-[(2-hydroxyphenyl)carbonyloxy]benzoic acid |
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| ID |
http://purl.obolibrary.org/obo/dinto_DB01399 |
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| ATCCode |
N02BA06 |
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| CASRN |
552-94-3 |
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| DBBrand |
disalcid |
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| DBSynonym |
sasapyrine salsalatum [inn-latin] salicylsalicylic acid |
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| Definition |
Salsalate is a nonsteroidal anti-inflammatory agent for oral administration. Salsalate s mode of action as an anti-inflammatory and antirheumatic agent may be due to inhibition of synthesis and release of prostaglandins. The usefulness of salicylic acid, the active in vivo product of salsalate, in the treatment of arthritic disorders has been established. In contrast to aspirin, salsalate causes no greater fecal gastrointestinal blood loss than placebo. Salsalate is readily soluble in the small intestine where it is partially hydrolyzed to two molecules of salicylic acid. A significant portion of the parent compound is absorbed unchanged and undergoes rapid esterase hydrolysis in the body. The parent compound has an elimination half-life of about 1 hour. Salicylic acid (the active metabolite) biotransformation is saturated at anti-inflammatory doses of salsalate. Such capacity limited biotransformation results in an increase in the half-life of salicylic acid from 3.5 to 16 or more hours. |
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| has effect |
http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000770 http://purl.obolibrary.org/obo/OAE_0001463 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0000607 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0000362 |
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| has pharmacological target | ||
| InChI |
InChI=1S/C14H10O5/c15-11-7-3-1-5-9(11)14(18)19-12-8-4-2-6-10(12)13(16)17/h1-8,15H,(H,16,17) |
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| InChIKey |
InChIKey=WVYADZUPLLSGPU-UHFFFAOYSA-N |
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| inhibits | ||
| label |
salsalate |
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| may interact with |
http://purl.obolibrary.org/obo/CHEBI_41879 http://purl.obolibrary.org/obo/dinto_DB00519 http://purl.obolibrary.org/obo/CHEBI_9352 http://purl.obolibrary.org/obo/CHEBI_32221 http://purl.obolibrary.org/obo/CHEBI_3650 http://purl.obolibrary.org/obo/CHEBI_5441 http://purl.obolibrary.org/obo/CHEBI_44185 http://purl.obolibrary.org/obo/CHEBI_3077 http://purl.obolibrary.org/obo/CHEBI_8382 http://purl.obolibrary.org/obo/CHEBI_17650 http://purl.obolibrary.org/obo/CHEBI_72014 http://purl.obolibrary.org/obo/CHEBI_50885 http://purl.obolibrary.org/obo/CHEBI_50861 http://purl.obolibrary.org/obo/dinto_DB00703 http://purl.obolibrary.org/obo/CHEBI_8378 http://purl.obolibrary.org/obo/CHEBI_8426 |
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| prefixIRI |
obo2:dinto_DB01399 |
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| prefLabel |
salsalate |
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| SMILES |
OC(=O)C1=CC=CC=C1OC(=O)C1=CC=CC=C1O |
|
| Synonym |
C14H10O5 2-[(2-hydroxyphenyl)carbonyloxy]benzoic acid |
|
| xref |
RxList:http://www.rxlist.com/cgi/generic/salsalate.htm PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/dis1142.shtml PubChem Substance:46506882 PubChem Compound:5161 ChemSpider:4977 Drugs.com:http://www.drugs.com/cdi/salsalate.html PharmGKB:PA164745462 |
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| subClassOf |