loading...| Preferred Name |
penbutolol |
|
| Synonyms |
C18H29NO2 tert-butyl[(2S)-3-(2-cyclopentylphenoxy)-2-hydroxypropyl]amine |
|
| ID |
http://purl.obolibrary.org/obo/dinto_DB01359 |
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| ATCCode |
C07AA23 |
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| blocks |
http://purl.obolibrary.org/obo/dinto_2907 |
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| CASRN |
36507-48-9 |
|
| DBBrand |
betapressin levatol levatolol lobeta |
|
| DBSalt |
penbutolol sulfate |
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| DBSynonym |
1-(tert-butylamino)-3-(o-cyclopentylphenoxy)propan-2-ol hoe 893d 2-propanol, 1-(2-cyclopentylphenoxy)-3-((1,1-dimethylethyl)amino)-, (s)- (2s)-1-(tert-butylamino)-3-(2-cyclopentylphenoxy)propan-2-ol penbutololum [inn-latin] hoe 893 |
|
| Definition |
Penbutolol is a drug in the beta-blocker class used to treat hypertension. Penbutolol binds both beta-1 and beta-2 adrenergic receptors, rendering it a non-selective beta-blocker. Penbutolol can act as a partial agonist at beta adrenergic receptors, since it is a sympathomimetric drug. Penbutolol also demonstrates high binding affinity to the 5-hydroxytryptamine receptor 1A with antagonistic effects. This binding characteristic of penbutolol is being investigated for its implications in Antidepressant Therapy. Penbutolol is contraindicated in patients with cardiogenic shock, sinus bradycardia, second and third degree atrioventricular conduction block, bronchial asthma, and those with known hypersensitivity. |
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| has pharmacological target |
http://purl.obolibrary.org/obo/dinto_2907 |
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| InChI |
InChI=1S/C18H29NO2/c1-18(2,3)19-12-15(20)13-21-17-11-7-6-10-16(17)14-8-4-5-9-14/h6-7,10-11,14-15,19-20H,4-5,8-9,12-13H2,1-3H3/t15-/m0/s1 |
|
| InChIKey |
InChIKey=KQXKVJAGOJTNJS-HNNXBMFYSA-N |
|
| label |
penbutolol |
|
| may interact with |
http://purl.obolibrary.org/obo/dinto_DB01303 http://purl.obolibrary.org/obo/CHEBI_4551 http://purl.obolibrary.org/obo/dinto_DB00912 http://purl.obolibrary.org/obo/CHEBI_28918 http://purl.obolibrary.org/obo/CHEBI_3650 http://purl.obolibrary.org/obo/CHEBI_5147 http://purl.obolibrary.org/obo/CHEBI_5441 http://purl.obolibrary.org/obo/CHEBI_49662 http://purl.obolibrary.org/obo/dinto_DB01223 http://purl.obolibrary.org/obo/CHEBI_8249 http://purl.obolibrary.org/obo/CHEBI_149226 http://purl.obolibrary.org/obo/CHEBI_584020 http://purl.obolibrary.org/obo/dinto_DB00047 http://purl.obolibrary.org/obo/CHEBI_5855 http://purl.obolibrary.org/obo/CHEBI_9449 http://purl.obolibrary.org/obo/CHEBI_9445 http://purl.obolibrary.org/obo/CHEBI_50861 http://purl.obolibrary.org/obo/CHEBI_61058 http://purl.obolibrary.org/obo/dinto_DB00236 http://purl.obolibrary.org/obo/CHEBI_4657 http://purl.obolibrary.org/obo/CHEBI_46631 http://purl.obolibrary.org/obo/CHEBI_6456 http://purl.obolibrary.org/obo/CHEBI_28177 http://purl.obolibrary.org/obo/CHEBI_8364 http://purl.obolibrary.org/obo/dinto_DB00816 http://purl.obolibrary.org/obo/CHEBI_64318 |
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| prefixIRI |
obo2:dinto_DB01359 |
|
| prefLabel |
penbutolol |
|
| related with |
http://purl.obolibrary.org/obo/dinto_2907 |
|
| SMILES |
CC(C)(C)NC[C@H](O)COC1=CC=CC=C1C1CCCC1 |
|
| Synonym |
C18H29NO2 tert-butyl[(2S)-3-(2-cyclopentylphenoxy)-2-hydroxypropyl]amine |
|
| xref |
PubChem Substance:46504929 Wikipedia:http://en.wikipedia.org/wiki/Penbutolol Drugs.com:http://www.drugs.com/cdi/penbutolol.html PharmGKB:PA164749474 PubChem Compound:37464 National Drug Code Directory:0091-4500-15 ChemSpider:34369 |
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| subClassOf |