The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	cilazapril
Synonyms	(1S,9S)-9-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-10-oxo-octahydro-1H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid C22H31N3O5
ID	http://purl.obolibrary.org/obo/dinto_DB01340
AHFScode	24:32.04
ATCCode	C09AA08
CASRN	92077-78-6
DBSynonym	inhibace
Definition	One of the angiotensin-converting enzyme inhibitors (ACE inhibitors) used for hypertension. It is a prodrug that is hydrolyzed after absorption to its main metabolite cilazaprilat. [PubChem]
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0001297 http://purl.obolibrary.org/obo/OAE_0000449 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0001373 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000902 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000218 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000479 http://purl.obolibrary.org/obo/OAE_0000659 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0000561 http://purl.obolibrary.org/obo/OAE_0001046 http://purl.obolibrary.org/obo/OAE_0000900 http://purl.obolibrary.org/obo/OAE_0000921 http://purl.obolibrary.org/obo/OAE_0000308 http://purl.obolibrary.org/obo/OAE_0001360 http://purl.obolibrary.org/obo/OAE_0000567 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000195 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0000021 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000317 http://purl.obolibrary.org/obo/OAE_0000660 http://purl.obolibrary.org/obo/OAE_0000197 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000050 http://purl.obolibrary.org/obo/OAE_0001365 http://purl.obolibrary.org/obo/OAE_0000476 http://purl.obolibrary.org/obo/OAE_0000770 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0001463 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0000455 http://purl.obolibrary.org/obo/OAE_0000084 http://purl.obolibrary.org/obo/OAE_0001200 http://purl.obolibrary.org/obo/OAE_0000268 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0000510 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000542 http://purl.obolibrary.org/obo/OAE_0000607 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000038 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0002122 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0000508 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0000343 http://purl.obolibrary.org/obo/OAE_0000536 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0001356 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000487 http://purl.obolibrary.org/obo/OAE_0001217 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000346 http://purl.obolibrary.org/obo/OAE_0000462 http://purl.obolibrary.org/obo/OAE_0001309 http://purl.obolibrary.org/obo/OAE_0001366 http://purl.obolibrary.org/obo/OAE_0000534 http://purl.obolibrary.org/obo/OAE_0000480 http://purl.obolibrary.org/obo/OAE_0001364 http://purl.obolibrary.org/obo/OAE_0000402 http://purl.obolibrary.org/obo/OAE_0000350
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2130
InChI	InChI=1S/C22H31N3O5/c1-2-30-22(29)18(13-12-16-8-4-3-5-9-16)23-17-10-6-14-24-15-7-11-19(21(27)28)25(24)20(17)26/h3-5,8-9,17-19,23H,2,6-7,10-15H2,1H3,(H,27,28)/t17-,18-,19-/m0/s1
InChIKey	InChIKey=HHHKFGXWKKUNCY-FHWLQOOXSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_2130
is transported by	http://purl.obolibrary.org/obo/dinto_4065 http://purl.obolibrary.org/obo/dinto_2004
label	cilazapril
may interact with	http://purl.obolibrary.org/obo/dinto_DB00384 http://purl.obolibrary.org/obo/CHEBI_50838 http://purl.obolibrary.org/obo/CHEBI_9241 http://purl.obolibrary.org/obo/dinto_DB01356 http://purl.obolibrary.org/obo/CHEBI_50861 http://purl.obolibrary.org/obo/CHEBI_63629 http://purl.obolibrary.org/obo/CHEBI_2639 http://purl.obolibrary.org/obo/dinto_DB01345
prefixIRI	obo2:dinto_DB01340
prefLabel	cilazapril
SMILES	CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@H]1CCCN2CCC[C@H](N2C1=O)C(O)=O
Synonym	(1S,9S)-9-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-10-oxo-octahydro-1H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid C22H31N3O5
xref	Drugs Product Database (DPD):1911465 Wikipedia:http://en.wikipedia.org/wiki/Cilazapril PharmGKB:PA164748302
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/XCO_0000592	XCO	LOOM
http://purl.obolibrary.org/obo/XCO_0000592	XCO	LOOM
http://purl.obolibrary.org/obo/CHEBI_3698	CHEBI	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000171771	NDFRT	LOOM
http://purl.jp/bio/4/id/200906015031969127	IOBC	LOOM
http://stirdf.jst.go.jp/id/200907051476840396	IOBC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0055723	OCHV	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018317	PMAPP-PMO	LOOM
http://www.co-ode.org/ontologies/galen#Cilazapril	GALEN	LOOM
http://purl.obolibrary.org/obo/CHEBI_3698	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_3698	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_3698	DRON	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.710.100	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D017315	RH-MESH	LOOM
http://scai.fraunhofer.de/AlzheimerOntology#cilazapril	ADO	LOOM
http://www.drugbank.ca/drugs/DB01340	FTC	LOOM
http://purl.obolibrary.org/obo/MESH_D017315	BERO	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/395947008	SNOMEDCT	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#13747	OCHV	LOOM
http://purl.bioontology.org/ontology/MESH/D017315	MESH	LOOM
http://purl.bioontology.org/ontology/NDDF/003950	NDDF	LOOM
http://purl.bioontology.org/ontology/RCD/bi8..	RCD	LOOM
https://go.drugbank.com/drugs/DB01340	MDM	LOOM
http://purl.bioontology.org/ontology/RXNORM/21102	RXNORM	LOOM
http://purl.obolibrary.org/obo/OMIT_0017691	OMIT	LOOM
http://purl.bioontology.org/ontology/ATC/C09AA08	ATC	LOOM
http://purl.bioontology.org/ontology/VANDF/4025239	VANDF	LOOM