The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	amiodarone
Synonyms	(2-{4-[(2-butyl-1-benzofuran-3-yl)carbonyl]-2,6-diiodophenoxy}ethyl)diethylamine C25H29I2NO3
ID	http://purl.obolibrary.org/obo/dinto_DB01118
AHFScode	24:04.04.20
ATCCode	C01BD01
blocks	http://purl.obolibrary.org/obo/dinto_2907
CASRN	1951-25-3
DBBrand	amio-aqueous iv labaz arycor pacerone cordarone intravenous amiodarons aminodarone cordarone pms-amiodarone aratac
DBSynonym	amiodaronum [inn-latin] amiodarone hcl amiodarone hydrochloride amiodarona [inn-spanish] amiodarone base
Definition	An antianginal and antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting Na,K-activated myocardial adenosine triphosphatase. There is a resulting decrease in heart rate and in vascular resistance. [PubChem]
has effect	http://purl.obolibrary.org/obo/OAE_0000238 http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0001297 http://purl.obolibrary.org/obo/OAE_0000449 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0000081 http://purl.obolibrary.org/obo/OAE_0001505 http://purl.obolibrary.org/obo/OAE_0000557 http://purl.obolibrary.org/obo/OAE_0000905 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0001045 http://purl.obolibrary.org/obo/OAE_0000630 http://purl.obolibrary.org/obo/OAE_0000218 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000659 http://purl.obolibrary.org/obo/OAE_0000617 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000921 http://purl.obolibrary.org/obo/OAE_0000512 http://purl.obolibrary.org/obo/OAE_0001253 http://purl.obolibrary.org/obo/OAE_0000308 http://purl.obolibrary.org/obo/OAE_0001008 http://purl.obolibrary.org/obo/OAE_0001449 http://purl.obolibrary.org/obo/OAE_0001369 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000195 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000577 http://purl.obolibrary.org/obo/OAE_0000418 http://purl.obolibrary.org/obo/OAE_0001013 http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0000021 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000333 http://purl.obolibrary.org/obo/OAE_0000197 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0001378 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0001365 http://purl.obolibrary.org/obo/OAE_0000920 http://purl.obolibrary.org/obo/OAE_0000169 http://purl.obolibrary.org/obo/OAE_0001063 http://purl.obolibrary.org/obo/OAE_0000770 http://purl.obolibrary.org/obo/OAE_0000454 http://purl.obolibrary.org/obo/OAE_0001238 http://purl.obolibrary.org/obo/OAE_0000287 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0001463 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0001275 http://purl.obolibrary.org/obo/OAE_0001300 http://purl.obolibrary.org/obo/OAE_0001024 http://purl.obolibrary.org/obo/OAE_0000911 http://purl.obolibrary.org/obo/OAE_0000434 http://purl.obolibrary.org/obo/OAE_0000268 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0001341 http://purl.obolibrary.org/obo/OAE_0000510 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0001135 http://purl.obolibrary.org/obo/OAE_0000842 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000542 http://purl.obolibrary.org/obo/OAE_0000607 http://purl.obolibrary.org/obo/OAE_0001155 http://purl.obolibrary.org/obo/OAE_0000525 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0001276 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0001145 http://purl.obolibrary.org/obo/OAE_0000866 http://purl.obolibrary.org/obo/OAE_0000835 http://purl.obolibrary.org/obo/OAE_0000780 http://purl.obolibrary.org/obo/OAE_0001403 http://purl.obolibrary.org/obo/OAE_0000647 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000194 http://purl.obolibrary.org/obo/OAE_0001205 http://purl.obolibrary.org/obo/OAE_0000185 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000779 http://purl.obolibrary.org/obo/OAE_0001217 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000565 http://purl.obolibrary.org/obo/OAE_0001345 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000881 http://purl.obolibrary.org/obo/OAE_0000260 http://purl.obolibrary.org/obo/OAE_0001035 http://purl.obolibrary.org/obo/OAE_0001366 http://purl.obolibrary.org/obo/OAE_0001364 http://purl.obolibrary.org/obo/OAE_0000402 http://purl.obolibrary.org/obo/OAE_0001298 http://purl.obolibrary.org/obo/OAE_0000506 http://purl.obolibrary.org/obo/OAE_0000304
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2907 http://purl.obolibrary.org/obo/dinto_3187 http://purl.obolibrary.org/obo/dinto_3113
InChI	InChI=1S/C25H29I2NO3/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3
InChIKey	InChIKey=IYIKLHRQXLHMJQ-UHFFFAOYSA-N
induces	http://purl.obolibrary.org/obo/dinto_1440
inhibits	http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_3187 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_3113 http://purl.obolibrary.org/obo/dinto_2260 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_1956
is metabolised by	http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0269 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1221
label	amiodarone
may interact with	http://purl.obolibrary.org/obo/CHEBI_32250 http://purl.obolibrary.org/obo/CHEBI_9948 http://purl.obolibrary.org/obo/CHEBI_4551 http://purl.obolibrary.org/obo/CHEBI_5280 http://purl.obolibrary.org/obo/CHEBI_8107 http://purl.obolibrary.org/obo/CHEBI_127342 http://purl.obolibrary.org/obo/CHEBI_41774 http://purl.obolibrary.org/obo/CHEBI_37924 http://purl.obolibrary.org/obo/dinto_DB00243 http://purl.obolibrary.org/obo/dinto_DB00224 http://purl.obolibrary.org/obo/CHEBI_4888 http://purl.obolibrary.org/obo/CHEBI_101278 http://purl.obolibrary.org/obo/CHEBI_40050 http://purl.obolibrary.org/obo/CHEBI_156095 http://purl.obolibrary.org/obo/CHEBI_70746 http://purl.obolibrary.org/obo/CHEBI_63611 http://purl.obolibrary.org/obo/CHEBI_4031 http://purl.obolibrary.org/obo/CHEBI_61049 http://purl.obolibrary.org/obo/dinto_DB00726 http://purl.obolibrary.org/obo/CHEBI_9150 http://purl.obolibrary.org/obo/dinto_DB00532 http://purl.obolibrary.org/obo/dinto_DB00342 http://purl.obolibrary.org/obo/CHEBI_53766 http://purl.obolibrary.org/obo/CHEBI_63632 http://purl.obolibrary.org/obo/CHEBI_6780 http://purl.obolibrary.org/obo/CHEBI_133809 http://purl.obolibrary.org/obo/CHEBI_9566 http://purl.obolibrary.org/obo/CHEBI_51364 http://purl.obolibrary.org/obo/CHEBI_63115 http://purl.obolibrary.org/obo/CHEBI_63598 http://purl.obolibrary.org/obo/CHEBI_63621 http://purl.obolibrary.org/obo/CHEBI_47657 http://purl.obolibrary.org/obo/CHEBI_59594 http://purl.obolibrary.org/obo/CHEBI_75984 http://purl.obolibrary.org/obo/CHEBI_9654 http://purl.obolibrary.org/obo/dinto_DB00582 http://purl.obolibrary.org/obo/dinto_DB00365 http://purl.obolibrary.org/obo/CHEBI_10119 http://purl.obolibrary.org/obo/CHEBI_9635 http://purl.obolibrary.org/obo/CHEBI_3720 http://purl.obolibrary.org/obo/CHEBI_3732 http://purl.obolibrary.org/obo/CHEBI_9622 http://purl.obolibrary.org/obo/CHEBI_9398 http://purl.obolibrary.org/obo/CHEBI_63629 http://purl.obolibrary.org/obo/CHEBI_10033 http://purl.obolibrary.org/obo/CHEBI_63628 http://purl.obolibrary.org/obo/CHEBI_45716 http://purl.obolibrary.org/obo/CHEBI_28593 http://purl.obolibrary.org/obo/dinto_DB00199 http://purl.obolibrary.org/obo/CHEBI_4513 http://purl.obolibrary.org/obo/dinto_DB00503 http://purl.obolibrary.org/obo/dinto_DB01319 http://purl.obolibrary.org/obo/dinto_DB01320 http://purl.obolibrary.org/obo/dinto_DB01362 http://purl.obolibrary.org/obo/CHEBI_8428 http://purl.obolibrary.org/obo/CHEBI_119915 http://purl.obolibrary.org/obo/CHEBI_68575 http://purl.obolibrary.org/obo/CHEBI_71226 http://purl.obolibrary.org/obo/CHEBI_28077 http://purl.obolibrary.org/obo/dinto_DB01346 http://purl.obolibrary.org/obo/dinto_DB06210 http://purl.obolibrary.org/obo/CHEBI_195280 http://purl.obolibrary.org/obo/dinto_DB00220 http://purl.obolibrary.org/obo/dinto_DB01208 http://purl.obolibrary.org/obo/dinto_DB01341 http://purl.obolibrary.org/obo/dinto_DB01623 http://purl.obolibrary.org/obo/dinto_DB06274 http://purl.obolibrary.org/obo/CHEBI_46295 http://purl.obolibrary.org/obo/dinto_DB00976
prefixIRI	obo2:dinto_DB01118
prefLabel	amiodarone
SMILES	CCCCC1=C(C(=O)C2=CC(I)=C(OCCN(CC)CC)C(I)=C2)C2=CC=CC=C2O1
Synonym	(2-{4-[(2-butyl-1-benzofuran-3-yl)carbonyl]-2,6-diiodophenoxy}ethyl)diethylamine C25H29I2NO3
xref	RxList:http://www.rxlist.com/cgi/generic/amiodarone.htm Wikipedia:http://en.wikipedia.org/wiki/Amiodarone ChEBI:2663 Drugs Product Database (DPD):2243836 BindingDB:18957 PharmGKB:PA448383 Guide To Pharmacology:2566 IUPHAR:2566 Drugs.com:http://www.drugs.com/amiodarone.html PubChem Substance:46507387 ChemSpider:2072 PubChem Compound:2157 National Drug Code Directory:0703-1332-03
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/XCO_0001124	XCO	LOOM
http://purl.obolibrary.org/obo/XCO_0001124	XCO	LOOM
http://purl.obolibrary.org/obo/CHEBI_2663	FYPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_2663	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_2663	HOIP	LOOM
http://purl.obolibrary.org/obo/CHEBI_2663	CHEBI	LOOM
https://go.drugbank.com/drugs/DB01118	MDM	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147701	ODAE	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147701	OCVDAE	LOOM
http://purl.jp/bio/4/id/200906047496006910	IOBC	LOOM
http://purl.bioontology.org/ontology/LNC/LP16028-0	LOINC	LOOM
http://purl.bioontology.org/ontology/MESH/D000638	MESH	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147701	NDFRT	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62002	NCIT	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#1026	OCHV	LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass39f879ce_8cbf_4320_af71_983c6e77c271	WWECA	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0002598	OCHV	LOOM
http://purl.bioontology.org/ontology/VANDF/4019606	VANDF	LOOM
http://purl.obolibrary.org/obo/MESH_D000638	BERO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D000638	RH-MESH	LOOM
http://purl.bioontology.org/ontology/RCD/x01QS	RCD	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU004841	LOINC	LOOM
http://purl.bioontology.org/ontology/CSP/0395-3720	CRISP	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372821002	SNOMEDCT	LOOM
http://purl.obolibrary.org/obo/OMIT_0002054	OMIT	LOOM
http://www.gamuts.net/entity#amiodarone	GAMUTS	LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02164	MIO	LOOM
http://bmi.utah.edu/ontologies/hfontology/C0002598	HFO	LOOM
http://stirdf.jst.go.jp/id/200907083679762667	IOBC	LOOM
http://www.drugbank.ca/drugs/DB01118	FTC	LOOM
http://purl.obolibrary.org/obo/NCIT_C62002	BERO	LOOM
http://purl.bioontology.org/ontology/ATC/C01BD01	ATC	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017610	PMAPP-PMO	LOOM
http://purl.bioontology.org/ontology/RXNORM/703	RXNORM	LOOM
http://www.co-ode.org/ontologies/galen#Amiodarone	GALEN	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.127.075	RH-MESH	LOOM
http://purl.bioontology.org/ontology/SNMI/C-80350	SNMI	LOOM
http://purl.obolibrary.org/obo/CHEBI_2663	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_2663	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_2663	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_2663	TXPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_2663	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_2663	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_2663	NIFSTD	LOOM
http://purl.obolibrary.org/obo/CHEBI_2663	DIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_2663	ODNAE	LOOM