loading...| Preferred Name |
novobiocin |
|
| Synonyms |
C31H36N2O11 (3R,4S,5R,6R)-5-hydroxy-6-[(4-hydroxy-3-{[4-hydroxy-3-(3-methylbut-2-en-1-yl)benzene]amido}-8-methyl-2-oxo-2H-chromen-7-yl)oxy]-3-methoxy-2,2-dimethyloxan-4-yl carbamate |
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| ID |
http://purl.obolibrary.org/obo/dinto_DB01051 |
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| CASRN |
303-81-1 |
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| DBBrand |
cathomycin cardelmycin inamycin sirbiocina spheromycin stilbiocina novo-r albamix streptonivicin albamycin cathocin robiocina |
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| DBSynonym |
novobiocina [inn-spanish] novobiocine [inn-french] nov crystallinic acid novobiocinum [inn-latin] antibiotic pa-93 |
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| Definition |
An antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189) [PubChem] |
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| has pharmacological target | ||
| InChI |
InChI=1S/C31H36N2O11/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29/h7,9-13,23,25-26,29,34-36H,8H2,1-6H3,(H2,32,39)(H,33,37)/t23-,25+,26-,29-/m1/s1 |
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| InChIKey |
InChIKey=YJQPYGGHQPGBLI-KGSXXDOSSA-N |
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| inhibits |
http://purl.obolibrary.org/obo/dinto_1975 http://purl.obolibrary.org/obo/dinto_0883 http://purl.obolibrary.org/obo/dinto_3090 http://purl.obolibrary.org/obo/dinto_4301 |
|
| label |
novobiocin |
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| prefixIRI |
obo2:dinto_DB01051 |
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| prefLabel |
novobiocin |
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| SMILES |
CO[C@@H]1[C@@H](OC(N)=O)[C@@H](O)[C@H](OC2=C(C)C3=C(C=C2)C(O)=C(NC(=O)C2=CC=C(O)C(CC=C(C)C)=C2)C(=O)O3)OC1(C)C |
|
| Synonym |
C31H36N2O11 (3R,4S,5R,6R)-5-hydroxy-6-[(4-hydroxy-3-{[4-hydroxy-3-(3-methylbut-2-en-1-yl)benzene]amido}-8-methyl-2-oxo-2H-chromen-7-yl)oxy]-3-methoxy-2,2-dimethyloxan-4-yl carbamate |
|
| xref |
PubChem Compound:9346 PDB:NOV BindingDB:282 PubChem Substance:46507250 ChemSpider:8981 Wikipedia:http://en.wikipedia.org/wiki/Novobiocin PharmGKB:PA164768819 |
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| subClassOf |