The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

hydrochlorothiazide

Synonyms

6-chloro-1,1-dioxo-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide

C7H8ClN3O4S2

ID

http://purl.obolibrary.org/obo/dinto_DB00999

AHFScode

40:28.20

ATCCode

C03AA03

CASRN

58-93-5

DBBrand

hydropres

hydrozide

apresazide

megadiuril

microzide

vetidrex

cidrex

timolide

bremil

hidroronol

hydrodiuretic

esidrex

neo-codema

hydrodiuril

nefrix

jen-diril

aquarills

hidril

hydrosaluric

thlaretic

dicyclotride

panurin

diu-melusin

chlorzide

drenol

direma

caplaril

fluvin

servithiazid

disalunil

ivaugan

hydro-aquil

hypothiazid

ro-hydrazide

newtolide

dichlorotride

idrotiazide

neoflumen

urodiazin

hydril

thiaretic

hidrotiazida

hypothiazide

aquarius

maschitt

hydrothide

dichlotiazid

chlorosulthiadil

dichlotride

diclotride

thiuretic

dichlorosal

hidrochlortiazid

DBSynonym

dihydrochlorothiazide

hctz

dihydrochlorurit

hydrochlorothiazid

dihydroxychlorothiazidum

dihydrochlorothiazid

hydrochlorthiazide

hcz

dihydrochlorurite

dihydrochlorothiazidum

Definition

A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It has been used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism. [PubChem]

has effect

http://purl.obolibrary.org/obo/OAE_0001195

http://purl.obolibrary.org/obo/OAE_0000505

http://purl.obolibrary.org/obo/OAE_0000355

http://purl.obolibrary.org/obo/OAE_0000400

http://purl.obolibrary.org/obo/OAE_0000401

http://purl.obolibrary.org/obo/OAE_0000377

http://purl.obolibrary.org/obo/OAE_0001345

http://purl.obolibrary.org/obo/OAE_0000643

http://purl.obolibrary.org/obo/OAE_0001106

http://purl.obolibrary.org/obo/OAE_0000218

http://purl.obolibrary.org/obo/OAE_0001509

http://purl.obolibrary.org/obo/OAE_0000473

http://purl.obolibrary.org/obo/OAE_0001129

http://purl.obolibrary.org/obo/OAE_0000449

http://purl.obolibrary.org/obo/OAE_0000496

http://purl.obolibrary.org/obo/OAE_0000333

http://purl.obolibrary.org/obo/OAE_0000391

http://purl.obolibrary.org/obo/OAE_0001448

http://purl.obolibrary.org/obo/OAE_0001025

http://purl.obolibrary.org/obo/OAE_0000300

http://purl.obolibrary.org/obo/OAE_0000600

http://purl.obolibrary.org/obo/OAE_0000534

http://purl.obolibrary.org/obo/OAE_0000913

http://purl.obolibrary.org/obo/OAE_0000406

http://purl.obolibrary.org/obo/OAE_0001520

http://purl.obolibrary.org/obo/OAE_0000866

http://purl.obolibrary.org/obo/OAE_0000396

http://purl.obolibrary.org/obo/OAE_0001339

http://purl.obolibrary.org/obo/OAE_0001373

http://purl.obolibrary.org/obo/OAE_0000596

http://purl.obolibrary.org/obo/OAE_0000468

http://purl.obolibrary.org/obo/OAE_0001053

http://purl.obolibrary.org/obo/OAE_0001064

http://purl.obolibrary.org/obo/OAE_0000375

http://purl.obolibrary.org/obo/OAE_0000287

http://purl.obolibrary.org/obo/OAE_0001378

http://purl.obolibrary.org/obo/OAE_0000374

http://purl.obolibrary.org/obo/OAE_0000630

http://purl.obolibrary.org/obo/OAE_0001515

http://purl.obolibrary.org/obo/OAE_0000851

http://purl.obolibrary.org/obo/OAE_0000365

http://purl.obolibrary.org/obo/OAE_0000343

http://purl.obolibrary.org/obo/OAE_0000319

http://purl.obolibrary.org/obo/OAE_0000376

http://purl.obolibrary.org/obo/OAE_0000487

http://purl.obolibrary.org/obo/OAE_0000508

http://purl.obolibrary.org/obo/OAE_0000195

http://purl.obolibrary.org/obo/OAE_0000921

http://purl.obolibrary.org/obo/OAE_0000382

http://purl.obolibrary.org/obo/OAE_0000752

http://purl.obolibrary.org/obo/OAE_0000358

http://purl.obolibrary.org/obo/OAE_0000565

http://purl.obolibrary.org/obo/OAE_0000460

http://purl.obolibrary.org/obo/OAE_0000402

http://purl.obolibrary.org/obo/OAE_0000034

http://purl.obolibrary.org/obo/OAE_0000021

http://purl.obolibrary.org/obo/OAE_0000415

http://purl.obolibrary.org/obo/OAE_0000601

http://purl.obolibrary.org/obo/OAE_0000310

http://purl.obolibrary.org/obo/OAE_0000243

http://purl.obolibrary.org/obo/OAE_0000645

http://purl.obolibrary.org/obo/OAE_0000453

http://purl.obolibrary.org/obo/OAE_0000647

http://purl.obolibrary.org/obo/OAE_0001051

http://purl.obolibrary.org/obo/OAE_0000038

http://purl.obolibrary.org/obo/OAE_0000498

http://purl.obolibrary.org/obo/OAE_0000347

http://purl.obolibrary.org/obo/OAE_0000394

http://purl.obolibrary.org/obo/OAE_0000086

http://purl.obolibrary.org/obo/OAE_0000350

http://purl.obolibrary.org/obo/OAE_0001465

http://purl.obolibrary.org/obo/OAE_0000166

http://purl.obolibrary.org/obo/OAE_0000602

http://purl.obolibrary.org/obo/OAE_0000536

http://purl.obolibrary.org/obo/OAE_0000210

http://purl.obolibrary.org/obo/OAE_0000561

http://purl.obolibrary.org/obo/OAE_0000825

http://purl.obolibrary.org/obo/OAE_0000388

http://purl.obolibrary.org/obo/OAE_0000584

http://purl.obolibrary.org/obo/OAE_0002122

http://purl.obolibrary.org/obo/OAE_0000362

http://purl.obolibrary.org/obo/OAE_0000373

http://purl.obolibrary.org/obo/OAE_0000551

has pharmacological target

http://purl.obolibrary.org/obo/dinto_0757

InChI

InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)

InChIKey

InChIKey=JZUFKLXOESDKRF-UHFFFAOYSA-N

inhibits

http://purl.obolibrary.org/obo/dinto_0512

http://purl.obolibrary.org/obo/dinto_3399

http://purl.obolibrary.org/obo/dinto_2115

http://purl.obolibrary.org/obo/dinto_0757

http://purl.obolibrary.org/obo/dinto_2357

http://purl.obolibrary.org/obo/dinto_0520

http://purl.obolibrary.org/obo/dinto_1621

label

hydrochlorothiazide

may interact with

http://purl.obolibrary.org/obo/dinto_DB00046

http://purl.obolibrary.org/obo/dinto_DB00519

http://purl.obolibrary.org/obo/dinto_DB00469

http://purl.obolibrary.org/obo/dinto_DB01396

http://purl.obolibrary.org/obo/CHEBI_4495

http://purl.obolibrary.org/obo/CHEBI_4551

http://purl.obolibrary.org/obo/CHEBI_31468

http://purl.obolibrary.org/obo/dinto_DB01356

http://purl.obolibrary.org/obo/CHEBI_4681

http://purl.obolibrary.org/obo/dinto_DB01551

http://purl.obolibrary.org/obo/CHEBI_68575

http://purl.obolibrary.org/obo/CHEBI_50861

prefixIRI

obo2:dinto_DB00999

prefLabel

hydrochlorothiazide

related with

http://purl.obolibrary.org/obo/dinto_3879

SMILES

NS(=O)(=O)C1=C(Cl)C=C2NCNS(=O)(=O)C2=C1

Synonym

6-chloro-1,1-dioxo-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide

C7H8ClN3O4S2

xref

Drugs.com:http://www.drugs.com/hctz.html

Drugs Product Database (DPD):2247386

BindingDB:13076

National Drug Code Directory:0378-3603-01

RxList:http://www.rxlist.com/cgi/generic/hctz.htm

Wikipedia:http://en.wikipedia.org/wiki/Hydrochlorothiazide

PharmGKB:PA449899

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

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http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.174.261.476 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/5487 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.655.500.261.476 RH-MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#6347 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D006852 RH-MESH LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000145995 OCVDAE LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29098 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29098 NCIT LOOM
http://bmi.utah.edu/ontologies/hfontology/C0020261 HFO LOOM
https://bioportal.bioontology.org/ontologies/FTDM.owl#hydrochlorothiazide FASTO LOOM
http://purl.jp/bio/4/id/200906026825052777 IOBC LOOM
http://www.co-ode.org/ontologies/galen#Hydrochlorothiazide GALEN LOOM
http://purl.bioontology.org/ontology/LNC/LP16160-1 LOINC LOOM
http://www.ifomis.org/acgt/1.0#Hydrochlorothiazide ACGT-MO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0020261 OCHV LOOM
http://purl.bioontology.org/ontology/MESH/D006852 MESH LOOM
http://purl.bioontology.org/ontology/UATC/C03AA03 ATC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000145995 NDFRT LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005360 FASTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005360 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005360 DMTO LOOM
http://www.gamuts.net/entity#hydrochlorothiazide GAMUTS LOOM
http://stirdf.jst.go.jp/id/200907079016032480 IOBC LOOM
http://purl.bioontology.org/ontology/NDDF/002294 NDDF LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005285 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005285 DMTO LOOM
http://purl.obolibrary.org/obo/XCO_0000552 XCO LOOM
http://purl.obolibrary.org/obo/XCO_0000552 XCO LOOM
http://purl.obolibrary.org/obo/DRON_00017941 DRON LOOM
http://purl.obolibrary.org/obo/DRON_00017941 DRON LOOM
http://purl.bioontology.org/ontology/RCD/b26.. RCD LOOM
http://www.drugbank.ca/drugs/DB00999 FTC LOOM
http://purl.obolibrary.org/obo/CHEBI_5778 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_5778 CHEBI LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.590.700.135.261.476 RH-MESH LOOM
http://purl.bioontology.org/ontology/LNC/MTHU016732 LOINC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387525002 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/VANDF/4017615 VANDF LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004868 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004868 DMTO LOOM
http://purl.bioontology.org/ontology/SNMI/C-72260 SNMI LOOM