The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

frovatriptan

Synonyms

(3R)-3-(methylamino)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamide

C14H17N3O

ID

http://purl.obolibrary.org/obo/dinto_DB00998

activates

http://purl.obolibrary.org/obo/dinto_2858

http://purl.obolibrary.org/obo/dinto_3332

ATCCode

N02CC07

CASRN

158747-02-5

DBBrand

miguard

frova

frovelan

DBSynonym

frovatriptan succinate

Definition

Frovatriptan (Frova?) is a triptan drug developed by Vernalis for the treatment of migraine headaches, in particular those associated with menstruation. The product is licensed to Endo Pharmaceuticals in North America and Menarini in Europe.[1] Frovatriptan causes vasoconstriction of arteries and veins that supply blood to the head. It is available as 2.5 mg tablets. Frovatriptan has mean terminal elimination half-life of approximately 26 hours, which is substantially longer than other triptans. Frovatriptan is available only by prescription in the United States, where a secondary New Drug Approval (sNDA) was filed in July 2006[2] and which is currently pending.[3] The FDA anticipates completing its review of this application on or before the current PDUFA (Prescription Drug User Fee Act) review date of August 19, 2007. If the sNDA is approved, Frova? will be the only medication indicated in the U.S. for the short-term prevention of menstrual migraine (MM).

has effect

http://purl.obolibrary.org/obo/OAE_0000426

http://purl.obolibrary.org/obo/OAE_0000081

http://purl.obolibrary.org/obo/OAE_0001057

http://purl.obolibrary.org/obo/OAE_0000505

http://purl.obolibrary.org/obo/OAE_0000355

http://purl.obolibrary.org/obo/OAE_0000400

http://purl.obolibrary.org/obo/OAE_0000390

http://purl.obolibrary.org/obo/OAE_0000401

http://purl.obolibrary.org/obo/OAE_0000608

http://purl.obolibrary.org/obo/OAE_0000567

http://purl.obolibrary.org/obo/OAE_0000218

http://purl.obolibrary.org/obo/OAE_0000473

http://purl.obolibrary.org/obo/OAE_0001461

http://purl.obolibrary.org/obo/OAE_0000495

http://purl.obolibrary.org/obo/OAE_0000333

http://purl.obolibrary.org/obo/OAE_0000391

http://purl.obolibrary.org/obo/OAE_0000300

http://purl.obolibrary.org/obo/OAE_0000600

http://purl.obolibrary.org/obo/OAE_0000611

http://purl.obolibrary.org/obo/OAE_0000533

http://purl.obolibrary.org/obo/OAE_0000545

http://purl.obolibrary.org/obo/OAE_0000385

http://purl.obolibrary.org/obo/OAE_0000198

http://purl.obolibrary.org/obo/OAE_0000406

http://purl.obolibrary.org/obo/OAE_0000050

http://purl.obolibrary.org/obo/OAE_0000396

http://purl.obolibrary.org/obo/OAE_0001200

http://purl.obolibrary.org/obo/OAE_0001538

http://purl.obolibrary.org/obo/OAE_0000502

http://purl.obolibrary.org/obo/OAE_0000317

http://purl.obolibrary.org/obo/OAE_0000375

http://purl.obolibrary.org/obo/OAE_0000374

http://purl.obolibrary.org/obo/OAE_0002206

http://purl.obolibrary.org/obo/OAE_0000539

http://purl.obolibrary.org/obo/OAE_0000586

http://purl.obolibrary.org/obo/OAE_0000517

http://purl.obolibrary.org/obo/OAE_0000470

http://purl.obolibrary.org/obo/OAE_0000482

http://purl.obolibrary.org/obo/OAE_0000493

http://purl.obolibrary.org/obo/OAE_0000597

http://purl.obolibrary.org/obo/OAE_0000365

http://purl.obolibrary.org/obo/OAE_0000343

http://purl.obolibrary.org/obo/OAE_0000308

http://purl.obolibrary.org/obo/OAE_0001369

http://purl.obolibrary.org/obo/OAE_0000487

http://purl.obolibrary.org/obo/OAE_0000542

http://purl.obolibrary.org/obo/OAE_0000508

http://purl.obolibrary.org/obo/OAE_0000382

http://purl.obolibrary.org/obo/OAE_0000414

http://purl.obolibrary.org/obo/OAE_0000460

http://purl.obolibrary.org/obo/OAE_0000402

http://purl.obolibrary.org/obo/OAE_0000805

http://purl.obolibrary.org/obo/OAE_0000034

http://purl.obolibrary.org/obo/OAE_0000021

http://purl.obolibrary.org/obo/OAE_0000601

http://purl.obolibrary.org/obo/OAE_0000612

http://purl.obolibrary.org/obo/OAE_0000310

http://purl.obolibrary.org/obo/OAE_0000453

http://purl.obolibrary.org/obo/OAE_0000038

http://purl.obolibrary.org/obo/OAE_0000350

http://purl.obolibrary.org/obo/OAE_0000166

http://purl.obolibrary.org/obo/OAE_0000211

http://purl.obolibrary.org/obo/OAE_0000602

http://purl.obolibrary.org/obo/OAE_0000536

http://purl.obolibrary.org/obo/OAE_0001055

http://purl.obolibrary.org/obo/OAE_0000561

http://purl.obolibrary.org/obo/OAE_0000388

http://purl.obolibrary.org/obo/OAE_0001309

http://purl.obolibrary.org/obo/OAE_0000433

http://purl.obolibrary.org/obo/OAE_0000607

http://purl.obolibrary.org/obo/OAE_0000373

has pharmacological target

http://purl.obolibrary.org/obo/dinto_2858

http://purl.obolibrary.org/obo/dinto_3332

InChI

InChI=1S/C14H17N3O/c1-16-9-3-5-13-11(7-9)10-6-8(14(15)18)2-4-12(10)17-13/h2,4,6,9,16-17H,3,5,7H2,1H3,(H2,15,18)/t9-/m1/s1

InChIKey

InChIKey=XPSQPHWEGNHMSK-SECBINFHSA-N

is metabolised by

http://purl.obolibrary.org/obo/dinto_2651

label

frovatriptan

may interact with

http://purl.obolibrary.org/obo/CHEBI_4562

http://purl.obolibrary.org/obo/CHEBI_4822

http://purl.obolibrary.org/obo/CHEBI_5118

http://purl.obolibrary.org/obo/CHEBI_9943

http://purl.obolibrary.org/obo/CHEBI_584020

http://purl.obolibrary.org/obo/CHEBI_7494

http://purl.obolibrary.org/obo/CHEBI_32250

http://purl.obolibrary.org/obo/CHEBI_5138

http://purl.obolibrary.org/obo/dinto_DB00752

http://purl.obolibrary.org/obo/dinto_DB06700

http://purl.obolibrary.org/obo/CHEBI_36791

http://purl.obolibrary.org/obo/CHEBI_10124

http://purl.obolibrary.org/obo/CHEBI_9654

http://purl.obolibrary.org/obo/dinto_DB00726

http://purl.obolibrary.org/obo/dinto_DB00353

http://purl.obolibrary.org/obo/CHEBI_7936

http://purl.obolibrary.org/obo/CHEBI_3723

http://purl.obolibrary.org/obo/CHEBI_64318

http://purl.obolibrary.org/obo/dinto_DB01105

http://purl.obolibrary.org/obo/CHEBI_9123

http://purl.obolibrary.org/obo/dinto_DB01287

prefixIRI

obo2:dinto_DB00998

prefLabel

frovatriptan

SMILES

CN[C@@H]1CCC2=C(C1)C1=C(N2)C=CC(=C1)C(N)=O

Synonym

(3R)-3-(methylamino)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamide

C14H17N3O

xref

National Drug Code Directory:63481-025-09

PubChem Compound:77992

PharmGKB:PA164754891

PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/fro1622.shtml

Drugs.com:http://www.drugs.com/cdi/frovatriptan.html

RxList:http://www.rxlist.com/cgi/generic3/frova.htm

ChemSpider:70378

PubChem Substance:46506288

BindingDB:50073689

Wikipedia:http://en.wikipedia.org/wiki/Frovatriptan

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

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http://purl.bioontology.org/ontology/RXNORM/228783 RXNORM LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C65772 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C65772 NCIT LOOM
http://www.drugbank.ca/drugs/DB00998 FTC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148734 NDFRT LOOM
http://purl.bioontology.org/ontology/UATC/N02CC07 ATC LOOM
http://purl.obolibrary.org/obo/DRON_00013614 DRON LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C108128 RH-MESH LOOM
http://purl.bioontology.org/ontology/MESH/C108128 MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_134991 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_134991 CHEBI LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/411990007 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/VANDF/4021297 VANDF LOOM