loading...| Preferred Name |
dactinomycin |
|
| Synonyms |
1-N,9-N-bis[(6S,9R,10S,13R,18aS)-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-6,13-bis(propan-2-yl)-hexadecahydro-1H-pyrrolo[2,1-i]1-oxa-4,7,10,13-tetraazacyclohexadecan-10-yl]-2-amino-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide C62H86N12O16 |
|
| ID |
http://purl.obolibrary.org/obo/dinto_DB00970 |
|
| AHFScode |
10:00.00 |
|
| ATCCode |
L01DA01 |
|
| CASRN |
50-76-0 |
|
| DBBrand |
meractinomycin cosmegen chounghwamycin b lyovac cosmegen |
|
| DBSynonym |
dactinomicina [inn-spanish] actinomycin c1 actinomycin d dactinomycinum [inn-latin] dactinomycine [inn-french] actd |
|
| Definition |
A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015) |
|
| has pharmacological target | ||
| InChI |
InChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)/t33-,34-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1 |
|
| InChIKey |
InChIKey=RJURFGZVJUQBHK-IIXSONLDSA-N |
|
| inhibits | ||
| is transported by |
http://purl.obolibrary.org/obo/dinto_0883 http://purl.obolibrary.org/obo/dinto_1993 |
|
| label |
dactinomycin |
|
| may interact with | ||
| prefixIRI |
obo2:dinto_DB00970 |
|
| prefLabel |
dactinomycin |
|
| related with | ||
| SMILES |
[H][C@@]12CCCN1C(=O)[C@H](NC(=O)[C@@H](NC(=O)C1=C3N=C4C(OC3=C(C)C=C1)=C(C)C(=O)C(N)=C4C(=O)N[C@H]1[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@]3([H])CCCN3C(=O)[C@H](NC1=O)C(C)C)[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C2=O)C(C)C |
|
| Synonym |
1-N,9-N-bis[(6S,9R,10S,13R,18aS)-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-6,13-bis(propan-2-yl)-hexadecahydro-1H-pyrrolo[2,1-i]1-oxa-4,7,10,13-tetraazacyclohexadecan-10-yl]-2-amino-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide C62H86N12O16 |
|
| xref |
ChEBI:27666 Drugs.com:http://www.drugs.com/cdi/dactinomycin.html Wikipedia:http://en.wikipedia.org/wiki/Dactinomycin BindingDB:50023797 RxList:http://www.rxlist.com/cgi/generic2/dactinomycin.htm Drugs Product Database (DPD):213071 PharmGKB:PA151917012 |
|
| subClassOf |