loading...| Preferred Name |
netilmicin |
|
| Synonyms |
(2R,3R,4R,5R)-2-{[(1S,2S,3R,4S,6R)-4-amino-3-{[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-6-(ethylamino)-2-hydroxycyclohexyl]oxy}-3-methyl-4-(methylamino)oxane-3,5-diol C21H41N5O7 |
|
| ID |
http://purl.obolibrary.org/obo/dinto_DB00955 |
|
| ATCCode |
J01GB07 S01AA23 |
|
| CASRN |
56391-56-1 |
|
| DBBrand |
netromycin |
|
| DBSynonym |
1-n-ethylsisomicin netilmycin |
|
| Definition |
Netilmicin is a semisynthetic 1-N-ethyl derivative of sisomycin, an aminoglycoside antibiotic with action similar to gentamicin, but less ear and kidney toxicity. [PubChem] Netilmicin inhibits protein synthesis in susceptible organisms by binding to the bacterial 30S ribosomal subunit and interfering with mRNA binding and the acceptor tRNA site. The bactericidal effect of netilmiicin is not fully understood. |
|
| has pharmacological target | ||
| InChI |
InChI=1S/C21H41N5O7/c1-4-26-13-7-12(24)16(32-19-11(23)6-5-10(8-22)31-19)15(28)17(13)33-20-21(2,29)18(25-3)14(27)9-30-20/h5,11-20,25-29H,4,6-9,22-24H2,1-3H3/t11-,12+,13-,14+,15+,16-,17+,18-,19-,20-,21-/m1/s1 |
|
| InChIKey |
InChIKey=ZBGPYVZLYBDXKO-HILBYHGXSA-N |
|
| inhibits | ||
| label |
netilmicin |
|
| may interact with |
http://purl.obolibrary.org/obo/CHEBI_553473 http://purl.obolibrary.org/obo/CHEBI_3213 http://purl.obolibrary.org/obo/CHEBI_9939 http://purl.obolibrary.org/obo/CHEBI_3499 http://purl.obolibrary.org/obo/CHEBI_3491 http://purl.obolibrary.org/obo/CHEBI_3493 http://purl.obolibrary.org/obo/CHEBI_3495 http://purl.obolibrary.org/obo/dinto_DB01338 http://purl.obolibrary.org/obo/CHEBI_3480 http://purl.obolibrary.org/obo/CHEBI_474053 http://purl.obolibrary.org/obo/dinto_DB03450 http://purl.obolibrary.org/obo/CHEBI_61049 http://purl.obolibrary.org/obo/CHEBI_9513 http://purl.obolibrary.org/obo/dinto_DB01336 http://purl.obolibrary.org/obo/dinto_DB01226 http://purl.obolibrary.org/obo/dinto_DB00214 http://purl.obolibrary.org/obo/CHEBI_45652 http://purl.obolibrary.org/obo/CHEBI_204928 http://purl.obolibrary.org/obo/CHEBI_3508 http://purl.obolibrary.org/obo/CHEBI_29007 http://purl.obolibrary.org/obo/dinto_DB01112 http://purl.obolibrary.org/obo/CHEBI_554446 http://purl.obolibrary.org/obo/CHEBI_8884 http://purl.obolibrary.org/obo/CHEBI_7907 http://purl.obolibrary.org/obo/CHEBI_9774 http://purl.obolibrary.org/obo/CHEBI_209807 http://purl.obolibrary.org/obo/CHEBI_2914 http://purl.obolibrary.org/obo/CHEBI_4876 http://purl.obolibrary.org/obo/CHEBI_47426 http://purl.obolibrary.org/obo/CHEBI_27899 |
|
| prefixIRI |
obo2:dinto_DB00955 |
|
| prefLabel |
netilmicin |
|
| SMILES |
CCN[C@@H]1C[C@H](N)[C@@H](O[C@H]2OC(CN)=CC[C@H]2N)[C@H](O)[C@H]1O[C@H]1OC[C@H](O)[C@@H](NC)[C@@]1(C)O |
|
| Synonym |
(2R,3R,4R,5R)-2-{[(1S,2S,3R,4S,6R)-4-amino-3-{[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-6-(ethylamino)-2-hydroxycyclohexyl]oxy}-3-methyl-4-(methylamino)oxane-3,5-diol C21H41N5O7 |
|
| xref |
Drugs Product Database (DPD):503371 Wikipedia:http://en.wikipedia.org/wiki/Netilmicin ChEBI:7528 PharmGKB:PA164754913 |
|
| subClassOf |