The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	granisetron
Synonyms	1-methyl-N-{9-methyl-9-azabicyclo[3.3.1]nonan-3-yl}-1H-indazole-3-carboxamide C18H24N4O
ID	http://purl.obolibrary.org/obo/dinto_DB00889
AHFScode	56:22.20
ATCCode	A04AA02
blocks	http://purl.obolibrary.org/obo/dinto_1123
CASRN	109889-09-0
DBBrand	kytril
DBSynonym	apf530 granisetronum [inn-latin] granisetron base granisetron hydrochloride granisetron hcl
Definition	A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. [PubChem]
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000218 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000659 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000660 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0001025 http://purl.obolibrary.org/obo/OAE_0000365 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0000455 http://purl.obolibrary.org/obo/OAE_0000498 http://purl.obolibrary.org/obo/OAE_0001420 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0002122 http://purl.obolibrary.org/obo/OAE_0001742 http://purl.obolibrary.org/obo/OAE_0000536 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000402
has pharmacological target	http://purl.obolibrary.org/obo/dinto_1123
InChI	InChI=1S/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23)
InChIKey	InChIKey=MFWNKCLOYSRHCJ-UHFFFAOYSA-N
induces	http://purl.obolibrary.org/obo/dinto_2993
inhibits	http://purl.obolibrary.org/obo/dinto_2993
is metabolised by	http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0269 http://purl.obolibrary.org/obo/dinto_0901
label	granisetron
prefixIRI	obo2:dinto_DB00889
prefLabel	granisetron
SMILES	CN1N=C(C(=O)NC2CC3CCCC(C2)N3C)C2=CC=CC=C12
Synonym	1-methyl-N-{9-methyl-9-azabicyclo[3.3.1]nonan-3-yl}-1H-indazole-3-carboxamide C18H24N4O
xref	PubChem Substance:46505137 PubChem Compound:3510 PharmGKB:PA449809 Drugs.com:http://www.drugs.com/cdi/granisetron.html Wikipedia:http://en.wikipedia.org/wiki/Granisetron BindingDB:50000483 Guide To Pharmacology:2300 IUPHAR:2300 Drugs Product Database (DPD):2088371 RxList:http://www.rxlist.com/cgi/generic/granisetron.htm ChemSpider:3390 National Drug Code Directory:0378-1003-94
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_5537	CHEBI	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000021915	NDFRT	LOOM
https://go.drugbank.com/drugs/DB00889	MDM	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#14123	OCHV	LOOM
http://purl.jp/bio/4/id/200906006176124746	IOBC	LOOM
http://purl.bioontology.org/ontology/MESH/D017829	MESH	LOOM
http://www.co-ode.org/ontologies/galen#Granisetron	GALEN	LOOM
http://purl.bioontology.org/ontology/ATC/A04AA02	ATC	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016251	PMAPP-PMO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.145.074.444	RH-MESH	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000794007	PDQ	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D017829	RH-MESH	LOOM
http://purl.bioontology.org/ontology/RXNORM/26237	RXNORM	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62031	NCIT	LOOM
http://purl.obolibrary.org/obo/NCIT_C62031	BERO	LOOM
http://purl.bioontology.org/ontology/VANDF/4023910	VANDF	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372489005	SNOMEDCT	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0061863	OCHV	LOOM
http://purl.obolibrary.org/obo/MESH_D017829	BERO	LOOM
http://stirdf.jst.go.jp/id/200907052436695101	IOBC	LOOM
http://purl.obolibrary.org/obo/OMIT_0018107	OMIT	LOOM
http://www.drugbank.ca/drugs/DB00889	FTC	LOOM
http://purl.obolibrary.org/obo/CHEBI_5537	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_5537	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_5537	DRON	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.129.539.487.350	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.449.350	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.075.080.875.099.444	RH-MESH	LOOM