The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

pentoxifylline

Synonyms

C13H18N4O3

3,7-dimethyl-1-(5-oxohexyl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione

ID

http://purl.obolibrary.org/obo/dinto_DB00806

AHFScode

20:24.00

ATCCode

C04AD03

blocks

http://purl.obolibrary.org/obo/dinto_0932

http://purl.obolibrary.org/obo/dinto_3607

CASRN

6493-05-6

DBBrand

pentoxifyllin

durapental

trental

azupentat

pentoxyphyline

dimethyloxohexylxanthine

rentylin

oxpentifylline

pentoxyphylline

torental

pentoxil

vazofirin

pentoxiphyllium

pentoxyfylline

DBSynonym

eht0201

Definition

A methylxanthine derivative that inhibits phosphodiesterase and affects blood rheology. It improves blood flow by increasing erythrocyte and leukocyte flexibility. It also inhibits platelet aggregation. Pentoxifylline modulates immunologic activity by stimulating cytokine production. [PubChem]

has effect

http://purl.obolibrary.org/obo/OAE_0000081

http://purl.obolibrary.org/obo/OAE_0000505

http://purl.obolibrary.org/obo/OAE_0000355

http://purl.obolibrary.org/obo/OAE_0000770

http://purl.obolibrary.org/obo/OAE_0000390

http://purl.obolibrary.org/obo/OAE_0000401

http://purl.obolibrary.org/obo/OAE_0000377

http://purl.obolibrary.org/obo/OAE_0001509

http://purl.obolibrary.org/obo/OAE_0000473

http://purl.obolibrary.org/obo/OAE_0001129

http://purl.obolibrary.org/obo/OAE_0000438

http://purl.obolibrary.org/obo/OAE_0001448

http://purl.obolibrary.org/obo/OAE_0001025

http://purl.obolibrary.org/obo/OAE_0000335

http://purl.obolibrary.org/obo/OAE_0000300

http://purl.obolibrary.org/obo/OAE_0000600

http://purl.obolibrary.org/obo/OAE_0000242

http://purl.obolibrary.org/obo/OAE_0000406

http://purl.obolibrary.org/obo/OAE_0000396

http://purl.obolibrary.org/obo/OAE_0001168

http://purl.obolibrary.org/obo/OAE_0000502

http://purl.obolibrary.org/obo/OAE_0000468

http://purl.obolibrary.org/obo/OAE_0000811

http://purl.obolibrary.org/obo/OAE_0000375

http://purl.obolibrary.org/obo/OAE_0000287

http://purl.obolibrary.org/obo/OAE_0000374

http://purl.obolibrary.org/obo/OAE_0002206

http://purl.obolibrary.org/obo/OAE_0000517

http://purl.obolibrary.org/obo/OAE_0000365

http://purl.obolibrary.org/obo/OAE_0000319

http://purl.obolibrary.org/obo/OAE_0001275

http://purl.obolibrary.org/obo/OAE_0000376

http://purl.obolibrary.org/obo/OAE_0000487

http://purl.obolibrary.org/obo/OAE_0000508

http://purl.obolibrary.org/obo/OAE_0000403

http://purl.obolibrary.org/obo/OAE_0000414

http://purl.obolibrary.org/obo/OAE_0000402

http://purl.obolibrary.org/obo/OAE_0000021

http://purl.obolibrary.org/obo/OAE_0000601

http://purl.obolibrary.org/obo/OAE_0000310

http://purl.obolibrary.org/obo/OAE_0000453

http://purl.obolibrary.org/obo/OAE_0000454

http://purl.obolibrary.org/obo/OAE_0000476

http://purl.obolibrary.org/obo/OAE_0000166

http://purl.obolibrary.org/obo/OAE_0000660

http://purl.obolibrary.org/obo/OAE_0000602

http://purl.obolibrary.org/obo/OAE_0000536

http://purl.obolibrary.org/obo/OAE_0000210

http://purl.obolibrary.org/obo/OAE_0000561

http://purl.obolibrary.org/obo/OAE_0000388

http://purl.obolibrary.org/obo/OAE_0000584

http://purl.obolibrary.org/obo/OAE_0002122

http://purl.obolibrary.org/obo/OAE_0000362

http://purl.obolibrary.org/obo/OAE_0000373

http://purl.obolibrary.org/obo/OAE_0000551

has pharmacological target

http://purl.obolibrary.org/obo/dinto_0932

http://purl.obolibrary.org/obo/dinto_1637

http://purl.obolibrary.org/obo/dinto_0074

http://purl.obolibrary.org/obo/dinto_3607

http://purl.obolibrary.org/obo/dinto_4063

InChI

InChI=1S/C13H18N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8H,4-7H2,1-3H3

InChIKey

InChIKey=BYPFEZZEUUWMEJ-UHFFFAOYSA-N

inhibits

http://purl.obolibrary.org/obo/dinto_1637

http://purl.obolibrary.org/obo/dinto_0074

http://purl.obolibrary.org/obo/dinto_0152

http://purl.obolibrary.org/obo/dinto_4063

is metabolised by

http://purl.obolibrary.org/obo/dinto_2651

label

pentoxifylline

may interact with

http://purl.obolibrary.org/obo/dinto_DB00046

http://purl.obolibrary.org/obo/CHEBI_28177

http://purl.obolibrary.org/obo/CHEBI_10033

http://purl.obolibrary.org/obo/CHEBI_4513

http://purl.obolibrary.org/obo/dinto_DB01223

http://purl.obolibrary.org/obo/dinto_DB01303

http://purl.obolibrary.org/obo/CHEBI_4728

http://purl.obolibrary.org/obo/CHEBI_133809

http://purl.obolibrary.org/obo/CHEBI_53766

prefixIRI

obo2:dinto_DB00806

prefLabel

pentoxifylline

SMILES

CN1C=NC2=C1C(=O)N(CCCCC(C)=O)C(=O)N2C

Synonym

C13H18N4O3

3,7-dimethyl-1-(5-oxohexyl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione

xref

BindingDB:10850

Wikipedia:http://en.wikipedia.org/wiki/Pentoxifylline

PharmGKB:PA450864

PubChem Substance:46505940

ChemSpider:4578

National Drug Code Directory:0378-0357-01

Drugs Product Database (DPD):1968432

RxList:http://www.rxlist.com/cgi/generic/pentox.htm

PubChem Compound:4740

Drugs.com:http://www.drugs.com/cdi/pentoxifylline.html

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

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https://bioportal.bioontology.org/ontologies/FTDM.owl#pentoxifylline FASTO LOOM
http://purl.jp/bio/4/id/200906055042872488 IOBC LOOM
http://purl.jp/bio/4/id/200906055042872488 IOBC LOOM
http://purl.jp/bio/4/id/200906055042872488 IOBC LOOM
http://purl.jp/bio/4/id/200906055042872488 IOBC LOOM
http://purl.bioontology.org/ontology/RXNORM/8013 RXNORM LOOM
http://purl.bioontology.org/ontology/CSP/4006-0076 CRISP LOOM
http://purl.bioontology.org/ontology/VANDF/4018468 VANDF LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000041432 PDQ LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D010431 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNMI/C-A7210 SNMI LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.759.758.824.651.700 RH-MESH LOOM
http://purl.bioontology.org/ontology/LNC/LP14918-4 LOINC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU035938 LOINC LOOM
http://purl.obolibrary.org/obo/CHEBI_7986 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_7986 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_7986 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_7986 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_7986 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_7986 CHEBI LOOM
http://stirdf.jst.go.jp/id/200907035146649783 IOBC LOOM
http://stirdf.jst.go.jp/id/200907035146649783 IOBC LOOM
http://stirdf.jst.go.jp/id/200907035146649783 IOBC LOOM
http://stirdf.jst.go.jp/id/200907035146649783 IOBC LOOM
http://purl.bioontology.org/ontology/MESH/D010431 MESH LOOM
http://purl.obolibrary.org/obo/DRON_00015511 DRON LOOM
http://purl.bioontology.org/ontology/NDDF/002098 NDDF LOOM
http://purl.bioontology.org/ontology/UATC/C04AD03 ATC LOOM
http://id.loc.gov/authorities/subjects/sh89005578 FAST-TOPICAL LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146791 NDFRT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C733 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C733 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C733 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C733 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C733 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C733 NCIT LOOM
http://www.drugbank.ca/drugs/DB00806 FTC LOOM
http://data.bnf.fr/ark:/12148/cb121985521 FAST-TOPICAL LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387522004 SNOMEDCT LOOM