The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	midazolam
Synonyms	C18H13ClFN3 12-chloro-9-(2-fluorophenyl)-3-methyl-2,4,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(10),3,5,8,11,13-hexaene
ID	http://purl.obolibrary.org/obo/dinto_DB00683
AHFScode	28:24.08
ATCCode	N05CD08
CASRN	59467-70-8
DBBrand	dormicum versed
DBSalt	midazolam hydrochloride
DBSynonym	midazolamum [inn-latin] midazolam hcl dea no. 2884 midazolam base
Definition	A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH. [PubChem] Midazolam is a schedule IV drug in the United States.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000218 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000617 http://purl.obolibrary.org/obo/OAE_0000267 http://purl.obolibrary.org/obo/OAE_0000650 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000900 http://purl.obolibrary.org/obo/OAE_0000512 http://purl.obolibrary.org/obo/OAE_0001449 http://purl.obolibrary.org/obo/OAE_0001369 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0001370 http://purl.obolibrary.org/obo/OAE_0000197 http://purl.obolibrary.org/obo/OAE_0000677 http://purl.obolibrary.org/obo/OAE_0000365 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000770 http://purl.obolibrary.org/obo/OAE_0000454 http://purl.obolibrary.org/obo/OAE_0000632 http://purl.obolibrary.org/obo/OAE_0000690 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0001483 http://purl.obolibrary.org/obo/OAE_0001461 http://purl.obolibrary.org/obo/OAE_0000587 http://purl.obolibrary.org/obo/OAE_0000586 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0001376 http://purl.obolibrary.org/obo/OAE_0000542 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0001742 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0000898 http://purl.obolibrary.org/obo/OAE_0000306 http://purl.obolibrary.org/obo/OAE_0000194 http://purl.obolibrary.org/obo/OAE_0001443 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000881 http://purl.obolibrary.org/obo/OAE_0000394
has pharmacological target	http://purl.obolibrary.org/obo/dinto_0016 http://purl.obolibrary.org/obo/dinto_0630 http://purl.obolibrary.org/obo/dinto_2875 http://purl.obolibrary.org/obo/dinto_0045 http://purl.obolibrary.org/obo/dinto_0043 http://purl.obolibrary.org/obo/dinto_0044 http://purl.obolibrary.org/obo/dinto_0111 http://purl.obolibrary.org/obo/dinto_0114 http://purl.obolibrary.org/obo/dinto_2853 http://purl.obolibrary.org/obo/dinto_1453 http://purl.obolibrary.org/obo/dinto_1457 http://purl.obolibrary.org/obo/dinto_2778 http://purl.obolibrary.org/obo/dinto_0109 http://purl.obolibrary.org/obo/dinto_0107 http://purl.obolibrary.org/obo/dinto_0199 http://purl.obolibrary.org/obo/dinto_0038 http://purl.obolibrary.org/obo/dinto_3062 http://purl.obolibrary.org/obo/dinto_1948 http://purl.obolibrary.org/obo/dinto_0159
InChI	InChI=1S/C18H13ClFN3/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13/h2-9H,10H2,1H3
InChIKey	InChIKey=DDLIGBOFAVUZHB-UHFFFAOYSA-N
induces	http://purl.obolibrary.org/obo/dinto_1440
inhibits	http://purl.obolibrary.org/obo/dinto_1970 http://purl.obolibrary.org/obo/dinto_0293 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_1956
is metabolised by	http://purl.obolibrary.org/obo/dinto_1675 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1956 http://purl.obolibrary.org/obo/dinto_0270 http://purl.obolibrary.org/obo/dinto_0465
is transported by	http://purl.obolibrary.org/obo/dinto_1440
label	midazolam
may interact with	http://purl.obolibrary.org/obo/CHEBI_119486 http://purl.obolibrary.org/obo/CHEBI_9948 http://purl.obolibrary.org/obo/CHEBI_119573 http://purl.obolibrary.org/obo/CHEBI_8107 http://purl.obolibrary.org/obo/CHEBI_68621 http://purl.obolibrary.org/obo/CHEBI_37924 http://purl.obolibrary.org/obo/CHEBI_4672 http://purl.obolibrary.org/obo/dinto_DB00224 http://purl.obolibrary.org/obo/CHEBI_4888 http://purl.obolibrary.org/obo/dinto_DB00196 http://purl.obolibrary.org/obo/CHEBI_499361 http://purl.obolibrary.org/obo/CHEBI_101278 http://purl.obolibrary.org/obo/CHEBI_40050 http://purl.obolibrary.org/obo/dinto_DB00532 http://purl.obolibrary.org/obo/CHEBI_3699 http://purl.obolibrary.org/obo/CHEBI_68595 http://purl.obolibrary.org/obo/dinto_DB01323 http://purl.obolibrary.org/obo/dinto_DB01322 http://purl.obolibrary.org/obo/dinto_DB01167 http://purl.obolibrary.org/obo/CHEBI_3766 http://purl.obolibrary.org/obo/CHEBI_63621 http://purl.obolibrary.org/obo/CHEBI_75045 http://purl.obolibrary.org/obo/dinto_DB00582 http://purl.obolibrary.org/obo/dinto_DB00427 http://purl.obolibrary.org/obo/CHEBI_63637 http://purl.obolibrary.org/obo/CHEBI_3387 http://purl.obolibrary.org/obo/CHEBI_3732 http://purl.obolibrary.org/obo/CHEBI_63628 http://purl.obolibrary.org/obo/dinto_DB00199 http://purl.obolibrary.org/obo/CHEBI_31413 http://purl.obolibrary.org/obo/CHEBI_7772 http://purl.obolibrary.org/obo/dinto_DB00503 http://purl.obolibrary.org/obo/dinto_DB01319 http://purl.obolibrary.org/obo/dinto_DB01369 http://purl.obolibrary.org/obo/CHEBI_31739 http://purl.obolibrary.org/obo/dinto_DB01320 http://purl.obolibrary.org/obo/dinto_DB01026 http://purl.obolibrary.org/obo/CHEBI_28077 http://purl.obolibrary.org/obo/dinto_DB00220 http://purl.obolibrary.org/obo/dinto_DB00976
prefixIRI	obo2:dinto_DB00683
prefLabel	midazolam
related with	http://purl.obolibrary.org/obo/dinto_0016 http://purl.obolibrary.org/obo/dinto_0630 http://purl.obolibrary.org/obo/dinto_2875 http://purl.obolibrary.org/obo/dinto_0045 http://purl.obolibrary.org/obo/dinto_0043 http://purl.obolibrary.org/obo/dinto_0044 http://purl.obolibrary.org/obo/dinto_0111 http://purl.obolibrary.org/obo/dinto_0114 http://purl.obolibrary.org/obo/dinto_2853 http://purl.obolibrary.org/obo/dinto_1453 http://purl.obolibrary.org/obo/dinto_1457 http://purl.obolibrary.org/obo/dinto_2778 http://purl.obolibrary.org/obo/dinto_0109 http://purl.obolibrary.org/obo/dinto_0107 http://purl.obolibrary.org/obo/dinto_0199 http://purl.obolibrary.org/obo/dinto_0038 http://purl.obolibrary.org/obo/dinto_3062 http://purl.obolibrary.org/obo/dinto_1948 http://purl.obolibrary.org/obo/dinto_0159
SMILES	CC1=NC=C2CN=C(C3=CC=CC=C3F)C3=C(C=CC(Cl)=C3)N12
Synonym	C18H13ClFN3 12-chloro-9-(2-fluorophenyl)-3-methyl-2,4,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(10),3,5,8,11,13-hexaene
xref	BindingDB:21363 PharmGKB:PA450496 PubChem Substance:46507611 RxList:http://www.rxlist.com/cgi/generic2/versedsyr.htm National Drug Code Directory:0574-0150-04 Wikipedia:http://en.wikipedia.org/wiki/Midazolam ChemSpider:4047 IUPHAR:3342 PubChem Compound:4192 Drugs Product Database (DPD):2240286 Guide To Pharmacology:3342 Drugs.com:http://www.drugs.com/cdi/midazolam.html
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_6931	CHEBI	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62049	NCIT	LOOM
http://purl.obolibrary.org/obo/MESH_D008874	BERO	LOOM
http://purl.bioontology.org/ontology/CSP/4000-0251	CRISP	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU003397	LOINC	LOOM
http://bmi.utah.edu/ontologies/hfontology/C0026056	HFO	LOOM
http://purl.bioontology.org/ontology/NDDF/004585	NDDF	LOOM
http://purl.bioontology.org/ontology/RCD/o57..	RCD	LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Midazolam	APAONTO	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#8125	OCHV	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D008874	RH-MESH	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0026056	OCHV	LOOM
http://purl.bioontology.org/ontology/VANDF/4019839	VANDF	LOOM
http://www.semanticweb.org/ftuha/ontologies/2021/5/FRMO-01untitled-ontology-175/Midazolam	FRMO	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017593	PMAPP-PMO	LOOM
http://purl.bioontology.org/ontology/SNMI/C-64580	SNMI	LOOM
http://purl.jp/bio/4/id/200906052225114877	IOBC	LOOM
http://purl.bioontology.org/ontology/MESH/D008874	MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.079.080.575	RH-MESH	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147927	NDFRT	LOOM
https://go.drugbank.com/drugs/DB00683	MDM	LOOM
http://purl.bioontology.org/ontology/RXNORM/6960	RXNORM	LOOM
http://purl.obolibrary.org/obo/CHEBI_6931	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_6931	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_6931	BAO	LOOM
http://purl.obolibrary.org/obo/CHEBI_6931	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_6931	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_6931	NIFSTD	LOOM
http://purl.obolibrary.org/obo/CHEBI_6931	DIDEO	LOOM
http://www.limics.fr/ontologies/ontoparonmed#Hypnovel	ONTOPARON	LOOM
http://www.drugbank.ca/drugs/DB00683	FTC	LOOM
http://stirdf.jst.go.jp/id/200907050212676214	IOBC	LOOM
http://purl.bioontology.org/ontology/ATC/N05CD08	ATC	LOOM
http://www.co-ode.org/ontologies/galen#Midazolam	GALEN	LOOM
http://purl.obolibrary.org/obo/OMIT_0009928	OMIT	LOOM
http://purl.obolibrary.org/obo/NCIT_C62049	BERO	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/373476007	SNOMEDCT	LOOM
http://purl.bioontology.org/ontology/LNC/LP16207-0	LOINC	LOOM