The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	nicardipine
Synonyms	C26H29N3O6 3-{2-[benzyl(methyl)amino]ethyl} 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
ID	http://purl.obolibrary.org/obo/dinto_DB00622
AHFScode	24:28.08
ATCCode	C08CA04
blocks	http://purl.obolibrary.org/obo/dinto_4020 http://purl.obolibrary.org/obo/dinto_3182 http://purl.obolibrary.org/obo/dinto_3475 http://purl.obolibrary.org/obo/dinto_1005 http://purl.obolibrary.org/obo/dinto_0703 http://purl.obolibrary.org/obo/dinto_3887 http://purl.obolibrary.org/obo/dinto_0234 http://purl.obolibrary.org/obo/dinto_2097
CASRN	55985-32-5
DBBrand	cardene iv cardene sr cardene
DBSynonym	nicardipine hcl nicardipino [inn-spanish] nicardipinum [inn-latin]
Definition	A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [PubChem]
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000879 http://purl.obolibrary.org/obo/OAE_0001297 http://purl.obolibrary.org/obo/OAE_0000497 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0001437 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000659 http://purl.obolibrary.org/obo/OAE_0000492 http://purl.obolibrary.org/obo/OAE_0000198 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0000561 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000921 http://purl.obolibrary.org/obo/OAE_0000611 http://purl.obolibrary.org/obo/OAE_0001449 http://purl.obolibrary.org/obo/OAE_0001369 http://purl.obolibrary.org/obo/OAE_0000567 http://purl.obolibrary.org/obo/OAE_0000021 http://purl.obolibrary.org/obo/OAE_0000412 http://purl.obolibrary.org/obo/OAE_0000465 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000317 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000050 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0001062 http://purl.obolibrary.org/obo/OAE_0000802 http://purl.obolibrary.org/obo/OAE_0001014 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000341 http://purl.obolibrary.org/obo/OAE_0000607 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000038 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0001742 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0001309 http://purl.obolibrary.org/obo/OAE_0000402 http://purl.obolibrary.org/obo/OAE_0000350
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2965 http://purl.obolibrary.org/obo/dinto_2979 http://purl.obolibrary.org/obo/dinto_3508 http://purl.obolibrary.org/obo/dinto_1027
InChI	InChI=1S/C26H29N3O6/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19/h5-12,15,24,27H,13-14,16H2,1-4H3
InChIKey	InChIKey=ZBBHBTPTTSWHBA-UHFFFAOYSA-N
induces	http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_0465
inhibits	http://purl.obolibrary.org/obo/dinto_2965 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_2979 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_0428 http://purl.obolibrary.org/obo/dinto_1221 http://purl.obolibrary.org/obo/dinto_3508 http://purl.obolibrary.org/obo/dinto_1027 http://purl.obolibrary.org/obo/dinto_3240
is metabolised by	http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0293 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1221
is transported by	http://purl.obolibrary.org/obo/dinto_1440
label	nicardipine
may interact with	http://purl.obolibrary.org/obo/dinto_DB00906 http://purl.obolibrary.org/obo/CHEBI_32250 http://purl.obolibrary.org/obo/CHEBI_9948 http://purl.obolibrary.org/obo/CHEBI_9943 http://purl.obolibrary.org/obo/CHEBI_4317 http://purl.obolibrary.org/obo/CHEBI_10100 http://purl.obolibrary.org/obo/CHEBI_71940 http://purl.obolibrary.org/obo/CHEBI_41774 http://purl.obolibrary.org/obo/dinto_DB00541 http://purl.obolibrary.org/obo/CHEBI_102166 http://purl.obolibrary.org/obo/CHEBI_10127 http://purl.obolibrary.org/obo/CHEBI_4031 http://purl.obolibrary.org/obo/CHEBI_61049 http://purl.obolibrary.org/obo/dinto_DB00726 http://purl.obolibrary.org/obo/dinto_DB06287 http://purl.obolibrary.org/obo/dinto_DB00342 http://purl.obolibrary.org/obo/dinto_DB00214 http://purl.obolibrary.org/obo/CHEBI_63632 http://purl.obolibrary.org/obo/dinto_DB00570 http://purl.obolibrary.org/obo/CHEBI_10125 http://purl.obolibrary.org/obo/CHEBI_9654 http://purl.obolibrary.org/obo/dinto_DB00582 http://purl.obolibrary.org/obo/dinto_DB01558 http://purl.obolibrary.org/obo/CHEBI_75988 http://purl.obolibrary.org/obo/CHEBI_480999 http://purl.obolibrary.org/obo/CHEBI_9622 http://purl.obolibrary.org/obo/CHEBI_50861 http://purl.obolibrary.org/obo/dinto_DB00440 http://purl.obolibrary.org/obo/CHEBI_9398 http://purl.obolibrary.org/obo/CHEBI_10033 http://purl.obolibrary.org/obo/CHEBI_32315 http://purl.obolibrary.org/obo/CHEBI_63628 http://purl.obolibrary.org/obo/dinto_DB01369 http://purl.obolibrary.org/obo/CHEBI_27999 http://purl.obolibrary.org/obo/CHEBI_46295 http://purl.obolibrary.org/obo/dinto_DB00976
prefixIRI	obo2:dinto_DB00622
prefLabel	nicardipine
related with	http://purl.obolibrary.org/obo/dinto_0753
SMILES	COC(=O)C1=C(C)NC(C)=C(C1C1=CC(=CC=C1)[N+]([O-])=O)C(=O)OCCN(C)CC1=CC=CC=C1
Synonym	C26H29N3O6 3-{2-[benzyl(methyl)amino]ethyl} 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
xref	Drugs Product Database (DPD):2162733 BindingDB:50017085 Guide To Pharmacology:2559 PubChem Substance:46504482 PharmGKB:PA450620 Wikipedia:http://en.wikipedia.org/wiki/Nicardipine IUPHAR:2559 Drugs.com:http://www.drugs.com/cdi/nicardipine.html PubChem Compound:4474 National Drug Code Directory:0703-8315-03 RxList:http://www.rxlist.com/cgi/generic/nicardipine.htm ChemSpider:4319
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_7550	CHEBI	LOOM
http://purl.bioontology.org/ontology/VANDF/4019858	VANDF	LOOM
http://www.semanticweb.org/ontologies/STO.owl#OWLClass_ed302533_ba69_46ff_b977_dc31e480854a	STO-DRAFT	LOOM
http://www.semanticweb.org/ontologies/STO.owl#OWLClass_ed302533_ba69_46ff_b977_dc31e480854a	CVAO	LOOM
http://purl.jp/bio/4/id/200906051612564086	IOBC	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372502001	SNOMEDCT	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU060584	LOINC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D009529	RH-MESH	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147944	NDFRT	LOOM
https://go.drugbank.com/drugs/DB00622	MDM	LOOM
http://www.co-ode.org/ontologies/galen#Nicardipine	GALEN	LOOM
http://purl.obolibrary.org/obo/NCIT_C66879	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_7550	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_7550	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_7550	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_7550	DRON	LOOM
http://purl.bioontology.org/ontology/CSP/2509-7900	CRISP	LOOM
http://purl.bioontology.org/ontology/MESH/D009529	MESH	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147944	OCVDAE	LOOM
http://purl.bioontology.org/ontology/LNC/LP66957-9	LOINC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.725.203.510	RH-MESH	LOOM
http://purl.bioontology.org/ontology/ATC/C08CA04	ATC	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66879	NCIT	LOOM
http://purl.bioontology.org/ontology/RXNORM/7396	RXNORM	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0028005	OCHV	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000753734	PDQ	LOOM
http://purl.bioontology.org/ontology/RCD/x01CV	RCD	LOOM
http://purl.obolibrary.org/obo/OMIT_0010552	OMIT	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018327	PMAPP-PMO	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#8702	OCHV	LOOM
http://stirdf.jst.go.jp/id/200907045742892844	IOBC	LOOM
http://purl.obolibrary.org/obo/MESH_D009529	BERO	LOOM
http://www.drugbank.ca/drugs/DB00622	FTC	LOOM