The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

vincristine

Synonyms

C46H56N4O10

methyl (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-(methoxycarbonyl)-1,11-diazatetracyclo[13.3.1.0^{4,12}.0^{5,10}]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraene-10-carboxylate

ID

http://purl.obolibrary.org/obo/dinto_DB00541

AHFScode

10:00.00

ATCCode

L01CA02

CASRN

57-22-7

DBBrand

vincrex

onco tcs

oncovin

vinkristin

vincasar pfs

marqibo

vincristine sulfate pfs

vincasar

DBSynonym

vincrstine

vcr

vincrystine

leurocristine

indole alkaloid

z-d-val-lys(z)-oh

lcr

vincristine sulfate

vin

vincristina [dcit]

22-oxovincaleukoblastine

vincristinum [inn-latin]

Definition

Vincristine is an antitumor vinca alkaloid isolated from Vinca Rosea. It is marketed under several brand names, many of which have different formulations such as Marqibo and Vincasar. Vincristine is indicated for the treatment of acute leukaemia, malignant lymphoma, Hodgkin s disease, acute erythraemia, and acute panmyelosis.

has effect

http://purl.obolibrary.org/obo/OAE_0000388

http://purl.obolibrary.org/obo/OAE_0000573

http://purl.obolibrary.org/obo/OAE_0000236

http://purl.obolibrary.org/obo/OAE_0000377

http://purl.obolibrary.org/obo/OAE_0000902

http://purl.obolibrary.org/obo/OAE_0000512

http://purl.obolibrary.org/obo/OAE_0001489

http://purl.obolibrary.org/obo/OAE_0000415

http://purl.obolibrary.org/obo/OAE_0000545

http://purl.obolibrary.org/obo/OAE_0000577

http://purl.obolibrary.org/obo/OAE_0000418

http://purl.obolibrary.org/obo/OAE_0001448

http://purl.obolibrary.org/obo/OAE_0000205

http://purl.obolibrary.org/obo/OAE_0001268

http://purl.obolibrary.org/obo/OAE_0000660

http://purl.obolibrary.org/obo/OAE_0000197

http://purl.obolibrary.org/obo/OAE_0001069

http://purl.obolibrary.org/obo/OAE_0000365

http://purl.obolibrary.org/obo/OAE_0000600

http://purl.obolibrary.org/obo/OAE_0000310

http://purl.obolibrary.org/obo/OAE_0000608

http://purl.obolibrary.org/obo/OAE_0000403

http://purl.obolibrary.org/obo/OAE_0000539

http://purl.obolibrary.org/obo/OAE_0001053

http://purl.obolibrary.org/obo/OAE_0000770

http://purl.obolibrary.org/obo/OAE_0000601

http://purl.obolibrary.org/obo/OAE_0000375

http://purl.obolibrary.org/obo/OAE_0000551

http://purl.obolibrary.org/obo/OAE_0000943

http://purl.obolibrary.org/obo/OAE_0001190

http://purl.obolibrary.org/obo/OAE_0001068

http://purl.obolibrary.org/obo/OAE_0000494

http://purl.obolibrary.org/obo/OAE_0000584

http://purl.obolibrary.org/obo/OAE_0001129

http://purl.obolibrary.org/obo/OAE_0002206

http://purl.obolibrary.org/obo/OAE_0000533

http://purl.obolibrary.org/obo/OAE_0000542

http://purl.obolibrary.org/obo/OAE_0000414

http://purl.obolibrary.org/obo/OAE_0000752

http://purl.obolibrary.org/obo/OAE_0000038

http://purl.obolibrary.org/obo/OAE_0000460

http://purl.obolibrary.org/obo/OAE_0000401

http://purl.obolibrary.org/obo/OAE_0000306

http://purl.obolibrary.org/obo/OAE_0001336

http://purl.obolibrary.org/obo/OAE_0000022

http://purl.obolibrary.org/obo/OAE_0000385

http://purl.obolibrary.org/obo/OAE_0000491

http://purl.obolibrary.org/obo/OAE_0000602

http://purl.obolibrary.org/obo/OAE_0001217

http://purl.obolibrary.org/obo/OAE_0000396

http://purl.obolibrary.org/obo/OAE_0000275

http://purl.obolibrary.org/obo/OAE_0000390

http://purl.obolibrary.org/obo/OAE_0000362

http://purl.obolibrary.org/obo/OAE_0000167

http://purl.obolibrary.org/obo/OAE_0000374

http://purl.obolibrary.org/obo/OAE_0000211

http://purl.obolibrary.org/obo/OAE_0000686

http://purl.obolibrary.org/obo/OAE_0000500

http://purl.obolibrary.org/obo/OAE_0000402

has pharmacological target

http://purl.obolibrary.org/obo/dinto_2701

InChI

InChI=1S/C46H56N4O10/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3/t28-,37+,38-,39-,42+,43-,44-,45+,46+/m1/s1

InChIKey

InChIKey=OGWKCGZFUXNPDA-XQKSVPLYSA-N

induces

http://purl.obolibrary.org/obo/dinto_1440

inhibits

http://purl.obolibrary.org/obo/dinto_0588

http://purl.obolibrary.org/obo/dinto_1972

http://purl.obolibrary.org/obo/dinto_1973

http://purl.obolibrary.org/obo/dinto_0887

http://purl.obolibrary.org/obo/dinto_2338

http://purl.obolibrary.org/obo/dinto_0901

http://purl.obolibrary.org/obo/dinto_1440

http://purl.obolibrary.org/obo/dinto_2701

http://purl.obolibrary.org/obo/dinto_2828

is metabolised by

http://purl.obolibrary.org/obo/dinto_2990

http://purl.obolibrary.org/obo/dinto_0901

http://purl.obolibrary.org/obo/dinto_1956

is transported by

http://purl.obolibrary.org/obo/dinto_1973

http://purl.obolibrary.org/obo/dinto_0887

http://purl.obolibrary.org/obo/dinto_0883

http://purl.obolibrary.org/obo/dinto_1440

http://purl.obolibrary.org/obo/dinto_3489

http://purl.obolibrary.org/obo/dinto_2828

label

vincristine

may interact with

http://purl.obolibrary.org/obo/CHEBI_4551

http://purl.obolibrary.org/obo/CHEBI_119573

http://purl.obolibrary.org/obo/CHEBI_37924

http://purl.obolibrary.org/obo/dinto_DB00108

http://purl.obolibrary.org/obo/dinto_DB00224

http://purl.obolibrary.org/obo/dinto_DB00196

http://purl.obolibrary.org/obo/CHEBI_499361

http://purl.obolibrary.org/obo/CHEBI_40050

http://purl.obolibrary.org/obo/CHEBI_7494

http://purl.obolibrary.org/obo/dinto_DB01601

http://purl.obolibrary.org/obo/CHEBI_474014

http://purl.obolibrary.org/obo/dinto_DB01167

http://purl.obolibrary.org/obo/CHEBI_63621

http://purl.obolibrary.org/obo/CHEBI_681850

http://purl.obolibrary.org/obo/dinto_DB00582

http://purl.obolibrary.org/obo/dinto_DB01110

http://purl.obolibrary.org/obo/CHEBI_3732

http://purl.obolibrary.org/obo/CHEBI_64355

http://purl.obolibrary.org/obo/CHEBI_28593

http://purl.obolibrary.org/obo/dinto_DB00199

http://purl.obolibrary.org/obo/dinto_DB00072

http://purl.obolibrary.org/obo/dinto_DB00503

http://purl.obolibrary.org/obo/dinto_DB01319

http://purl.obolibrary.org/obo/dinto_DB01369

http://purl.obolibrary.org/obo/dinto_DB01026

http://purl.obolibrary.org/obo/dinto_DB00305

http://purl.obolibrary.org/obo/CHEBI_367163

http://purl.obolibrary.org/obo/dinto_DB00220

http://purl.obolibrary.org/obo/dinto_DB00622

http://purl.obolibrary.org/obo/dinto_DB00976

http://purl.obolibrary.org/obo/CHEBI_45783

http://purl.obolibrary.org/obo/dinto_DB00951

http://purl.obolibrary.org/obo/CHEBI_6402

prefixIRI

obo2:dinto_DB00541

prefLabel

vincristine

SMILES

[H][C@@]12N3CC[C@@]11C4=CC(=C(OC)C=C4N(C=O)[C@@]1([H])[C@](O)([C@H](OC(C)=O)[C@]2(CC)C=CC3)C(=O)OC)[C@]1(C[C@]2([H])CN(C[C@](O)(CC)C2)CCC2=C1NC1=CC=CC=C21)C(=O)OC

Synonym

C46H56N4O10

methyl (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-(methoxycarbonyl)-1,11-diazatetracyclo[13.3.1.0^{4,12}.0^{5,10}]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraene-10-carboxylate

xref

PharmGKB:PA451879

ChemSpider:5758

Wikipedia:http://en.wikipedia.org/wiki/Vincristine

Drugs Product Database (DPD):2143305

PubChem Compound:5978

ChEBI:28445

RxList:http://www.rxlist.com/cgi/generic3/vincristine.htm

PubChem Substance:46507033

National Drug Code Directory:61703-309-06

Drugs.com:http://www.drugs.com/cdi/vincristine.html

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_28445 OBA LOOM
http://purl.bioontology.org/ontology/RCD/x01Ak RCD LOOM
http://purl.bioontology.org/ontology/MESH/D014750 MESH LOOM
http://www.ifomis.org/acgt/1.0#Vincristine ACGT-MO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.132.436.681.827.817 RH-MESH LOOM
http://purl.obolibrary.org/obo/OMIT_0015581 OMIT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387126006 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/CHEBI_28445 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_28445 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_28445 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_28445 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_28445 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_28445 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_28445 OBA LOOM
http://purl.obolibrary.org/obo/CHEBI_28445 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_28445 NIFSTD LOOM
http://doe-generated-ontology.com/OntoAD#C0042679 ONTOAD LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.473.402.681.827.817 RH-MESH LOOM
http://stirdf.jst.go.jp/id/200907069534389671 IOBC LOOM
http://purl.bioontology.org/ontology/VANDF/4019971 VANDF LOOM
http://purl.bioontology.org/ontology/RXNORM/11202 RXNORM LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C933 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C933 ROO LOOM
http://purl.bioontology.org/ontology/CSP/0093-3871 CRISP LOOM
http://purl.bioontology.org/ontology/SNMI/C-78250 SNMI LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#13000 OCHV LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148056 NDFRT LOOM
http://www.drugbank.ca/drugs/DB00541 FTC LOOM
http://purl.obolibrary.org/obo/MESH_D014750 BERO LOOM
http://purl.jp/bio/4/id/200906049284629472 IOBC LOOM
http://purl.bioontology.org/ontology/ATC/L01CA02 ATC LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017737 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/NDDF/004894 NDDF LOOM
http://purl.obolibrary.org/obo/NCIT_C933 BERO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D014750 RH-MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0042679 OCHV LOOM
https://go.drugbank.com/drugs/DB00541 MDM LOOM
http://www.gamuts.net/entity#vincristine GAMUTS LOOM
http://www.co-ode.org/ontologies/galen#Vincristine GALEN LOOM