The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

trandolapril

Synonyms

C24H34N2O5

(2S,3aR,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-octahydro-1H-indole-2-carboxylic acid

ID

http://purl.obolibrary.org/obo/dinto_DB00519

AHFScode

24:32.04

ATCCode

C09AA10

CASRN

87679-37-6

DBBrand

mavik

DBSynonym

trandolaprilum [latin]

Definition

Trandolapril is a non-sulhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to its biologically active diacid form, trandolaprilat, in the liver. Trandolaprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Trandolapril may be used to treat mild to moderate hypertension, to improve survival following myocardial infarction in clinically stable patients with left ventricular dysfunction, as an adjunct treatment for congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.

has effect

http://purl.obolibrary.org/obo/OAE_0000599

http://purl.obolibrary.org/obo/OAE_0000505

http://purl.obolibrary.org/obo/OAE_0000355

http://purl.obolibrary.org/obo/OAE_0000400

http://purl.obolibrary.org/obo/OAE_0000390

http://purl.obolibrary.org/obo/OAE_0000401

http://purl.obolibrary.org/obo/OAE_0000377

http://purl.obolibrary.org/obo/OAE_0000968

http://purl.obolibrary.org/obo/OAE_0000218

http://purl.obolibrary.org/obo/OAE_0000462

http://purl.obolibrary.org/obo/OAE_0001129

http://purl.obolibrary.org/obo/OAE_0000920

http://purl.obolibrary.org/obo/OAE_0001403

http://purl.obolibrary.org/obo/OAE_0001045

http://purl.obolibrary.org/obo/OAE_0000344

http://purl.obolibrary.org/obo/OAE_0000391

http://purl.obolibrary.org/obo/OAE_0001448

http://purl.obolibrary.org/obo/OAE_0001025

http://purl.obolibrary.org/obo/OAE_0000300

http://purl.obolibrary.org/obo/OAE_0001046

http://purl.obolibrary.org/obo/OAE_0000716

http://purl.obolibrary.org/obo/OAE_0000600

http://purl.obolibrary.org/obo/OAE_0000533

http://purl.obolibrary.org/obo/OAE_0000534

http://purl.obolibrary.org/obo/OAE_0000385

http://purl.obolibrary.org/obo/OAE_0000198

http://purl.obolibrary.org/obo/OAE_0000557

http://purl.obolibrary.org/obo/OAE_0000406

http://purl.obolibrary.org/obo/OAE_0000050

http://purl.obolibrary.org/obo/OAE_0001164

http://purl.obolibrary.org/obo/OAE_0000301

http://purl.obolibrary.org/obo/OAE_0000396

http://purl.obolibrary.org/obo/OAE_0001003

http://purl.obolibrary.org/obo/OAE_0001373

http://purl.obolibrary.org/obo/OAE_0001200

http://purl.obolibrary.org/obo/OAE_0000596

http://purl.obolibrary.org/obo/OAE_0000894

http://purl.obolibrary.org/obo/OAE_0000512

http://purl.obolibrary.org/obo/OAE_0001053

http://purl.obolibrary.org/obo/OAE_0000375

http://purl.obolibrary.org/obo/OAE_0000479

http://purl.obolibrary.org/obo/OAE_0000374

http://purl.obolibrary.org/obo/OAE_0000250

http://purl.obolibrary.org/obo/OAE_0002206

http://purl.obolibrary.org/obo/OAE_0001364

http://purl.obolibrary.org/obo/OAE_0000839

http://purl.obolibrary.org/obo/OAE_0000022

http://purl.obolibrary.org/obo/OAE_0000365

http://purl.obolibrary.org/obo/OAE_0000343

http://purl.obolibrary.org/obo/OAE_0000308

http://purl.obolibrary.org/obo/OAE_0001369

http://purl.obolibrary.org/obo/OAE_0000084

http://purl.obolibrary.org/obo/OAE_0000945

http://purl.obolibrary.org/obo/OAE_0000497

http://purl.obolibrary.org/obo/OAE_0000508

http://purl.obolibrary.org/obo/OAE_0000195

http://purl.obolibrary.org/obo/OAE_0000921

http://purl.obolibrary.org/obo/OAE_0000382

http://purl.obolibrary.org/obo/OAE_0000414

http://purl.obolibrary.org/obo/OAE_0000358

http://purl.obolibrary.org/obo/OAE_0000565

http://purl.obolibrary.org/obo/OAE_0000460

http://purl.obolibrary.org/obo/OAE_0000402

http://purl.obolibrary.org/obo/OAE_0000034

http://purl.obolibrary.org/obo/OAE_0000021

http://purl.obolibrary.org/obo/OAE_0000415

http://purl.obolibrary.org/obo/OAE_0000601

http://purl.obolibrary.org/obo/OAE_0000310

http://purl.obolibrary.org/obo/OAE_0000243

http://purl.obolibrary.org/obo/OAE_0000453

http://purl.obolibrary.org/obo/OAE_0000647

http://purl.obolibrary.org/obo/OAE_0000498

http://purl.obolibrary.org/obo/OAE_0000476

http://purl.obolibrary.org/obo/OAE_0000905

http://purl.obolibrary.org/obo/OAE_0000660

http://purl.obolibrary.org/obo/OAE_0000602

http://purl.obolibrary.org/obo/OAE_0000536

http://purl.obolibrary.org/obo/OAE_0000210

http://purl.obolibrary.org/obo/OAE_0001055

http://purl.obolibrary.org/obo/OAE_0000388

http://purl.obolibrary.org/obo/OAE_0000526

http://purl.obolibrary.org/obo/OAE_0000584

http://purl.obolibrary.org/obo/OAE_0000443

http://purl.obolibrary.org/obo/OAE_0002122

http://purl.obolibrary.org/obo/OAE_0000455

http://purl.obolibrary.org/obo/OAE_0000362

http://purl.obolibrary.org/obo/OAE_0001309

http://purl.obolibrary.org/obo/OAE_0001319

http://purl.obolibrary.org/obo/OAE_0000607

http://purl.obolibrary.org/obo/OAE_0000238

http://purl.obolibrary.org/obo/OAE_0000720

http://purl.obolibrary.org/obo/OAE_0000373

http://purl.obolibrary.org/obo/OAE_0000551

has pharmacological target

http://purl.obolibrary.org/obo/dinto_2130

InChI

InChI=1S/C24H34N2O5/c1-3-31-24(30)19(14-13-17-9-5-4-6-10-17)25-16(2)22(27)26-20-12-8-7-11-18(20)15-21(26)23(28)29/h4-6,9-10,16,18-21,25H,3,7-8,11-15H2,1-2H3,(H,28,29)/t16-,18+,19-,20-,21-/m0/s1

InChIKey

InChIKey=VXFJYXUZANRPDJ-WTNASJBWSA-N

inhibits

http://purl.obolibrary.org/obo/dinto_2130

is metabolised by

http://purl.obolibrary.org/obo/dinto_0470

is transported by

http://purl.obolibrary.org/obo/dinto_2004

http://purl.obolibrary.org/obo/dinto_4065

label

trandolapril

may interact with

http://purl.obolibrary.org/obo/dinto_DB01324

http://purl.obolibrary.org/obo/CHEBI_72014

http://purl.obolibrary.org/obo/CHEBI_68564

http://purl.obolibrary.org/obo/CHEBI_8249

http://purl.obolibrary.org/obo/CHEBI_50838

http://purl.obolibrary.org/obo/dinto_DB01345

http://purl.obolibrary.org/obo/dinto_DB01399

http://purl.obolibrary.org/obo/CHEBI_9434

http://purl.obolibrary.org/obo/CHEBI_6128

http://purl.obolibrary.org/obo/dinto_DB00465

http://purl.obolibrary.org/obo/dinto_DB01577

http://purl.obolibrary.org/obo/CHEBI_64354

http://purl.obolibrary.org/obo/CHEBI_40279

http://purl.obolibrary.org/obo/dinto_DB01579

http://purl.obolibrary.org/obo/CHEBI_8080

http://purl.obolibrary.org/obo/CHEBI_31547

http://purl.obolibrary.org/obo/dinto_DB00461

http://purl.obolibrary.org/obo/dinto_DB01240

http://purl.obolibrary.org/obo/CHEBI_4495

http://purl.obolibrary.org/obo/CHEBI_47426

http://purl.obolibrary.org/obo/CHEBI_2948

http://purl.obolibrary.org/obo/CHEBI_3044

http://purl.obolibrary.org/obo/CHEBI_48416

http://purl.obolibrary.org/obo/CHEBI_4909

http://purl.obolibrary.org/obo/dinto_DB00939

http://purl.obolibrary.org/obo/CHEBI_9927

http://purl.obolibrary.org/obo/CHEBI_2636

http://purl.obolibrary.org/obo/CHEBI_41423

http://purl.obolibrary.org/obo/dinto_DB00310

http://purl.obolibrary.org/obo/CHEBI_3640

http://purl.obolibrary.org/obo/dinto_DB00232

http://purl.obolibrary.org/obo/CHEBI_3347

http://purl.obolibrary.org/obo/CHEBI_7476

http://purl.obolibrary.org/obo/CHEBI_15854

http://purl.obolibrary.org/obo/dinto_DB00784

http://purl.obolibrary.org/obo/CHEBI_32139

http://purl.obolibrary.org/obo/dinto_DB00384

http://purl.obolibrary.org/obo/CHEBI_4876

http://purl.obolibrary.org/obo/CHEBI_27565

http://purl.obolibrary.org/obo/CHEBI_5855

http://purl.obolibrary.org/obo/CHEBI_6887

http://purl.obolibrary.org/obo/CHEBI_3013

http://purl.obolibrary.org/obo/dinto_DB01404

http://purl.obolibrary.org/obo/CHEBI_5893

http://purl.obolibrary.org/obo/CHEBI_4814

http://purl.obolibrary.org/obo/dinto_DB01021

http://purl.obolibrary.org/obo/CHEBI_39669

http://purl.obolibrary.org/obo/CHEBI_5959

http://purl.obolibrary.org/obo/CHEBI_7822

http://purl.obolibrary.org/obo/CHEBI_9352

http://purl.obolibrary.org/obo/dinto_DB01356

http://purl.obolibrary.org/obo/dinto_DB01363

http://purl.obolibrary.org/obo/dinto_DB06287

http://purl.obolibrary.org/obo/CHEBI_68845

http://purl.obolibrary.org/obo/CHEBI_2639

http://purl.obolibrary.org/obo/CHEBI_9241

http://purl.obolibrary.org/obo/CHEBI_15365

http://purl.obolibrary.org/obo/dinto_DB00214

http://purl.obolibrary.org/obo/CHEBI_5004

http://purl.obolibrary.org/obo/CHEBI_6541

http://purl.obolibrary.org/obo/dinto_DB00814

http://purl.obolibrary.org/obo/CHEBI_47381

http://purl.obolibrary.org/obo/CHEBI_4031

http://purl.obolibrary.org/obo/dinto_DB00073

http://purl.obolibrary.org/obo/CHEBI_73044

http://purl.obolibrary.org/obo/dinto_DB00761

http://purl.obolibrary.org/obo/dinto_DB00440

http://purl.obolibrary.org/obo/dinto_DB00999

http://purl.obolibrary.org/obo/CHEBI_3213

http://purl.obolibrary.org/obo/dinto_DB00774

http://purl.obolibrary.org/obo/CHEBI_50861

http://purl.obolibrary.org/obo/CHEBI_49662

http://purl.obolibrary.org/obo/dinto_DB01255

http://purl.obolibrary.org/obo/CHEBI_63629

http://purl.obolibrary.org/obo/CHEBI_9168

http://purl.obolibrary.org/obo/CHEBI_5130

http://purl.obolibrary.org/obo/CHEBI_32221

http://purl.obolibrary.org/obo/CHEBI_4469

http://purl.obolibrary.org/obo/CHEBI_63916

prefixIRI

obo2:dinto_DB00519

prefLabel

trandolapril

SMILES

[H][C@@]12C[C@H](N(C(=O)[C@H](C)N[C@@H](CCC3=CC=CC=C3)C(=O)OCC)[C@@]1([H])CCCC2)C(O)=O

Synonym

C24H34N2O5

(2S,3aR,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-octahydro-1H-indole-2-carboxylic acid

xref

Drugs.com:http://www.drugs.com/cdi/trandolapril.html

Drugs Product Database (DPD):2239267

PubChem Substance:46508300

PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/tar1425.shtml

RxList:http://www.rxlist.com/cgi/generic3/mavik.htm

PharmGKB:PA451737

National Drug Code Directory:65862-164-01

Wikipedia:http://en.wikipedia.org/wiki/Trandolapril

PubChem Compound:5484727

ChemSpider:4588590

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

Delete Subject Author Type Created
No notes to display
Create New Mapping

Delete Mapping To Ontology Source
http://www.drugbank.ca/drugs/DB00519 FTC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C052035 RH-MESH LOOM
http://www.co-ode.org/ontologies/galen#Trandolapril GALEN LOOM
http://purl.bioontology.org/ontology/UATC/C09AA10 ATC LOOM
http://purl.bioontology.org/ontology/RXNORM/38454 RXNORM LOOM
http://purl.bioontology.org/ontology/RXNORM/38454 NLMVS LOOM
http://purl.bioontology.org/ontology/VANDF/4020971 VANDF LOOM
http://purl.obolibrary.org/obo/CHEBI_9649 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_9649 NBO LOOM
http://purl.obolibrary.org/obo/CHEBI_9649 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_9649 CHEBI LOOM
http://purl.bioontology.org/ontology/RCD/bi9.. RCD LOOM
http://purl.bioontology.org/ontology/NDDF/004452 NDDF LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61978 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61978 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61978 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61978 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61978 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61978 NCIT LOOM
http://mimi.case.edu/ontologies/2009/9/DrugOntology#trandolapril SDO LOOM
http://purl.obolibrary.org/obo/DRON_00016394 DRON LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148444 NDFRT LOOM
http://scai.fraunhofer.de/AlzheimerOntology#trandolapril ADO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/108562001 SNOMEDCT LOOM
http://stirdf.jst.go.jp/id/200907070351713842 IOBC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386871006 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/MESH/C052035 MESH LOOM
https://bioportal.bioontology.org/ontologies/FTDM.owl#trandolapril FASTO LOOM
http://bmi.utah.edu/ontologies/hfontology/C0076891 HFO LOOM
http://purl.jp/bio/4/id/200906074806220418 IOBC LOOM
http://purl.jp/bio/4/id/200906074806220418 IOBC LOOM