The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

duloxetine

Synonyms

methyl[(3S)-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propyl]amine

C18H19NOS

ID

http://purl.obolibrary.org/obo/dinto_DB00476

ATCCode

N06AX21

CASRN

136434-34-9

DBBrand

yentreve

cymbalta

DBSynonym

duloxetine hydrochloride

duloxetine hcl

Definition

Duloxetine (brand names Cymbalta, Yentreve, and in parts of Europe, Xeristar or Ariclaim) is a drug which primarily targets major depressive disorder (MDD), generalized anxiety disorder (GAD), pain related to diabetic peripheral neuropathy and in some countries stress urinary incontinence (SUI). It is manufactured and marketed by Eli Lilly and Company. Duloxetine has not yet been FDA approved for stress urinary incontinence or for fibromyalgia. Duloxetine is a selective SNRI (selective serotonin-norepinephrine reuptake inhibitor). Duloxetine is a systemic drug therapy which affects the body as a whole. Known also under the code name LY248686, it is a potent dual reuptake inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE), possessing comparable affinities in binding to NE- and 5-HT transporter sites. It is a less potent inhibitor of dopamine reuptake.

has effect

http://purl.obolibrary.org/obo/OAE_0000388

http://purl.obolibrary.org/obo/OAE_0000496

http://purl.obolibrary.org/obo/OAE_0000449

http://purl.obolibrary.org/obo/OAE_0000453

http://purl.obolibrary.org/obo/OAE_0001373

http://purl.obolibrary.org/obo/OAE_0000597

http://purl.obolibrary.org/obo/OAE_0000081

http://purl.obolibrary.org/obo/OAE_0000236

http://purl.obolibrary.org/obo/OAE_0000604

http://purl.obolibrary.org/obo/OAE_0000905

http://purl.obolibrary.org/obo/OAE_0000377

http://purl.obolibrary.org/obo/OAE_0001045

http://purl.obolibrary.org/obo/OAE_0000902

http://purl.obolibrary.org/obo/OAE_0000391

http://purl.obolibrary.org/obo/OAE_0000839

http://purl.obolibrary.org/obo/OAE_0000630

http://purl.obolibrary.org/obo/OAE_0000376

http://purl.obolibrary.org/obo/OAE_0000479

http://purl.obolibrary.org/obo/OAE_0000659

http://purl.obolibrary.org/obo/OAE_0000492

http://purl.obolibrary.org/obo/OAE_0000267

http://purl.obolibrary.org/obo/OAE_0000561

http://purl.obolibrary.org/obo/OAE_0000825

http://purl.obolibrary.org/obo/OAE_0001509

http://purl.obolibrary.org/obo/OAE_0000443

http://purl.obolibrary.org/obo/OAE_0000921

http://purl.obolibrary.org/obo/OAE_0000512

http://purl.obolibrary.org/obo/OAE_0000308

http://purl.obolibrary.org/obo/OAE_0001489

http://purl.obolibrary.org/obo/OAE_0000415

http://purl.obolibrary.org/obo/OAE_0000545

http://purl.obolibrary.org/obo/OAE_0000373

http://purl.obolibrary.org/obo/OAE_0000210

http://purl.obolibrary.org/obo/OAE_0000319

http://purl.obolibrary.org/obo/OAE_0000021

http://purl.obolibrary.org/obo/OAE_0000967

http://purl.obolibrary.org/obo/OAE_0000412

http://purl.obolibrary.org/obo/OAE_0001448

http://purl.obolibrary.org/obo/OAE_0000317

http://purl.obolibrary.org/obo/OAE_0000660

http://purl.obolibrary.org/obo/OAE_0000333

http://purl.obolibrary.org/obo/OAE_0001051

http://purl.obolibrary.org/obo/OAE_0000382

http://purl.obolibrary.org/obo/OAE_0000250

http://purl.obolibrary.org/obo/OAE_0000600

http://purl.obolibrary.org/obo/OAE_0000050

http://purl.obolibrary.org/obo/OAE_0000883

http://purl.obolibrary.org/obo/OAE_0000476

http://purl.obolibrary.org/obo/OAE_0000608

http://purl.obolibrary.org/obo/OAE_0000945

http://purl.obolibrary.org/obo/OAE_0001063

http://purl.obolibrary.org/obo/OAE_0000360

http://purl.obolibrary.org/obo/OAE_0000601

http://purl.obolibrary.org/obo/OAE_0000375

http://purl.obolibrary.org/obo/OAE_0000551

http://purl.obolibrary.org/obo/OAE_0000691

http://purl.obolibrary.org/obo/OAE_0000517

http://purl.obolibrary.org/obo/OAE_0000455

http://purl.obolibrary.org/obo/OAE_0000498

http://purl.obolibrary.org/obo/OAE_0000502

http://purl.obolibrary.org/obo/OAE_0000084

http://purl.obolibrary.org/obo/OAE_0001057

http://purl.obolibrary.org/obo/OAE_0001295

http://purl.obolibrary.org/obo/OAE_0001515

http://purl.obolibrary.org/obo/OAE_0000526

http://purl.obolibrary.org/obo/OAE_0000309

http://purl.obolibrary.org/obo/OAE_0000400

http://purl.obolibrary.org/obo/OAE_0000086

http://purl.obolibrary.org/obo/OAE_0000645

http://purl.obolibrary.org/obo/OAE_0000584

http://purl.obolibrary.org/obo/OAE_0001129

http://purl.obolibrary.org/obo/OAE_0000842

http://purl.obolibrary.org/obo/OAE_0000542

http://purl.obolibrary.org/obo/OAE_0000315

http://purl.obolibrary.org/obo/OAE_0001233

http://purl.obolibrary.org/obo/OAE_0000473

http://purl.obolibrary.org/obo/OAE_0001004

http://purl.obolibrary.org/obo/OAE_0000607

http://purl.obolibrary.org/obo/OAE_0001155

http://purl.obolibrary.org/obo/OAE_0000355

http://purl.obolibrary.org/obo/OAE_0000727

http://purl.obolibrary.org/obo/OAE_0000038

http://purl.obolibrary.org/obo/OAE_0001164

http://purl.obolibrary.org/obo/OAE_0000968

http://purl.obolibrary.org/obo/OAE_0000166

http://purl.obolibrary.org/obo/OAE_0000344

http://purl.obolibrary.org/obo/OAE_0000460

http://purl.obolibrary.org/obo/OAE_0000866

http://purl.obolibrary.org/obo/OAE_0000401

http://purl.obolibrary.org/obo/OAE_0000780

http://purl.obolibrary.org/obo/OAE_0000343

http://purl.obolibrary.org/obo/OAE_0001403

http://purl.obolibrary.org/obo/OAE_0000536

http://purl.obolibrary.org/obo/OAE_0000898

http://purl.obolibrary.org/obo/OAE_0000505

http://purl.obolibrary.org/obo/OAE_0000194

http://purl.obolibrary.org/obo/OAE_0001356

http://purl.obolibrary.org/obo/OAE_0000022

http://purl.obolibrary.org/obo/OAE_0000385

http://purl.obolibrary.org/obo/OAE_0000468

http://purl.obolibrary.org/obo/OAE_0000602

http://purl.obolibrary.org/obo/OAE_0000336

http://purl.obolibrary.org/obo/OAE_0001147

http://purl.obolibrary.org/obo/OAE_0000779

http://purl.obolibrary.org/obo/OAE_0001052

http://purl.obolibrary.org/obo/OAE_0000396

http://purl.obolibrary.org/obo/OAE_0000390

http://purl.obolibrary.org/obo/OAE_0000362

http://purl.obolibrary.org/obo/OAE_0000296

http://purl.obolibrary.org/obo/OAE_0000501

http://purl.obolibrary.org/obo/OAE_0001166

http://purl.obolibrary.org/obo/OAE_0000881

http://purl.obolibrary.org/obo/OAE_0000394

http://purl.obolibrary.org/obo/OAE_0000242

http://purl.obolibrary.org/obo/OAE_0000211

http://purl.obolibrary.org/obo/OAE_0000358

http://purl.obolibrary.org/obo/OAE_0001309

http://purl.obolibrary.org/obo/OAE_0000885

http://purl.obolibrary.org/obo/OAE_0000402

has pharmacological target

http://purl.obolibrary.org/obo/dinto_2714

http://purl.obolibrary.org/obo/dinto_0068

InChI

InChI=1S/C18H19NOS/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16/h2-10,13,17,19H,11-12H2,1H3/t17-/m0/s1

InChIKey

InChIKey=ZEUITGRIYCTCEM-KRWDZBQOSA-N

inhibits

http://purl.obolibrary.org/obo/dinto_2714

http://purl.obolibrary.org/obo/dinto_3343

http://purl.obolibrary.org/obo/dinto_2993

http://purl.obolibrary.org/obo/dinto_0068

is metabolised by

http://purl.obolibrary.org/obo/dinto_2651

http://purl.obolibrary.org/obo/dinto_2993

label

duloxetine

may interact with

http://purl.obolibrary.org/obo/CHEBI_32250

http://purl.obolibrary.org/obo/CHEBI_9943

http://purl.obolibrary.org/obo/CHEBI_41774

http://purl.obolibrary.org/obo/dinto_DB00540

http://purl.obolibrary.org/obo/dinto_DB00857

http://purl.obolibrary.org/obo/CHEBI_47499

http://purl.obolibrary.org/obo/dinto_DB00726

http://purl.obolibrary.org/obo/CHEBI_9566

http://purl.obolibrary.org/obo/dinto_DB00780

http://purl.obolibrary.org/obo/CHEBI_75984

http://purl.obolibrary.org/obo/CHEBI_9654

http://purl.obolibrary.org/obo/dinto_DB00427

http://purl.obolibrary.org/obo/CHEBI_100241

http://purl.obolibrary.org/obo/CHEBI_5138

http://purl.obolibrary.org/obo/CHEBI_8466

http://purl.obolibrary.org/obo/dinto_DB01247

http://purl.obolibrary.org/obo/CHEBI_9398

http://purl.obolibrary.org/obo/dinto_DB00752

http://purl.obolibrary.org/obo/CHEBI_45979

http://purl.obolibrary.org/obo/CHEBI_63620

http://purl.obolibrary.org/obo/CHEBI_10124

http://purl.obolibrary.org/obo/CHEBI_47781

http://purl.obolibrary.org/obo/CHEBI_2666

http://purl.obolibrary.org/obo/dinto_DB06700

prefixIRI

obo2:dinto_DB00476

prefLabel

duloxetine

SMILES

CNCC[C@H](OC1=CC=CC2=CC=CC=C12)C1=CC=CS1

Synonym

methyl[(3S)-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propyl]amine

C18H19NOS

xref

PubChem Substance:46507937

PharmGKB:PA10066

Drugs.com:http://www.drugs.com/cdi/duloxetine-delayed-release-capsules.html

RxList:http://www.rxlist.com/cgi/generic/cymbalta.htm

PubChem Compound:60835

Wikipedia:http://en.wikipedia.org/wiki/Duloxetine

IUPHAR:202

ChEBI:36795

Guide To Pharmacology:202

National Drug Code Directory:54868-5215-2

ChemSpider:54822

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_36796 OBA LOOM
http://www.case.edu/EpilepsyOntology.owl#Duloxetine EPSO LOOM
http://www.case.edu/EpSO.owl#Duloxetine MEPO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/407032004 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/LNC/MTHU064054 LOINC LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClassec302ee0_08e7_446d_bba4_0a5454f255d0 WWECA LOOM
http://purl.bioontology.org/ontology/LNC/LP40294-8 LOINC LOOM
http://scai.fraunhofer.de/AlzheimerOntology#duloxetine ADO LOOM
https://go.drugbank.com/drugs/DB00476 MDM LOOM
http://purl.bioontology.org/ontology/NDDF/008705 NDDF LOOM
http://purl.obolibrary.org/obo/CHEBI_36795 FIDEO LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass771678e9_ead6_40b0_882b_3f0e64319d70 WWECA LOOM
http://purl.obolibrary.org/obo/NCIT_C65495 BERO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148860 NDFRT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#25137 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C058218 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/72625 RXNORM LOOM
http://purl.obolibrary.org/obo/NCIT_65495 SCDO LOOM
http://purl.obolibrary.org/obo/CHEBI_36796 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_36796 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_36796 HOIP LOOM
http://purl.obolibrary.org/obo/CHEBI_36796 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_36796 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_36796 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_36796 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_36796 OBA LOOM
http://purl.obolibrary.org/obo/CHEBI_36796 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_36796 NIFSTD LOOM
http://purl.bioontology.org/ontology/ATC/N06AX21 ATC LOOM
https://bioportal.bioontology.org/ontologies/STMSO#Duloxetine STMSO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0245561 OCHV LOOM
http://www.drugbank.ca/drugs/DB00476 FTC LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C65495 NCIT LOOM
http://purl.bioontology.org/ontology/VANDF/4021477 VANDF LOOM
http://purl.bioontology.org/ontology/LNC/MTHU060573 LOINC LOOM