loading...| Preferred Name |
loratadine |
|
| Synonyms |
C22H23ClN2O2 ethyl 4-{13-chloro-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-2-ylidene}piperidine-1-carboxylate |
|
| ID |
http://purl.obolibrary.org/obo/dinto_DB00455 |
|
| AHFScode |
04:08.00 24:32.04 |
|
| ATCCode |
R06AX27 C09AA03 R06AX13 |
|
| blocks | ||
| CASRN |
79794-75-5 |
|
| DBBrand |
lesidas claritin reditabs fristamin bonalerg nularef loradex loritine claritin roletra talorat dy lomilan loranox civeran clarityne alerpriv rinomex rhinase histaloran sensibit alavert clarityn allertidin lertamine biloina loraver restamine lorastine lergy claratyne versal loracert sinhistan dy clarinase zeos optimin lorfast alarin loradif lorantis pylor loratyne clarinase reperabs velodan bedix loratadina claritin-d tadine claritine polaratyne lowadina lisino aerotina sohotin sanelor |
|
| DBSynonym |
loratadinum [latin] loratadina [spanish] |
|
| Definition |
Loratadine is a derivative of azatadine and a second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (histamine H1 antagonists) it lacks central nervous system depressing effects such as drowsiness. [PubChem] |
|
| has effect |
http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000492 http://purl.obolibrary.org/obo/OAE_0000308 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0001463 http://purl.obolibrary.org/obo/OAE_0000455 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000968 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000362 |
|
| has pharmacological target | ||
| InChI |
InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3 |
|
| InChIKey |
InChIKey=JCCNYMKQOSZNPW-UHFFFAOYSA-N |
|
| induces |
http://purl.obolibrary.org/obo/dinto_2993 |
|
| inhibits |
http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0901 |
|
| is metabolised by |
http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2993 |
|
| label |
loratadine |
|
| may interact with |
http://purl.obolibrary.org/obo/dinto_DB00209 http://purl.obolibrary.org/obo/CHEBI_7494 http://purl.obolibrary.org/obo/dinto_DB00427 |
|
| prefixIRI |
obo2:dinto_DB00455 |
|
| prefLabel |
loratadine |
|
| SMILES |
CCOC(=O)N1CCC(CC1)=C1C2=C(CCC3=C1N=CC=C3)C=C(Cl)C=C2 |
|
| Synonym |
C22H23ClN2O2 ethyl 4-{13-chloro-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-2-ylidene}piperidine-1-carboxylate |
|
| xref |
Drugs.com:http://www.drugs.com/cdi/loratadine.html Wikipedia:http://en.wikipedia.org/wiki/Loratadine PubChem Substance:46507853 PubChem Compound:3957 National Drug Code Directory:0378-1925-01 Drugs Product Database (DPD):2244692 BindingDB:22876 PharmGKB:PA450266 ChemSpider:3820 |
|
| subClassOf |