The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	chlorthalidone
Synonyms	C14H11ClN2O4S 2-chloro-5-(1-hydroxy-3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzene-1-sulfonamide
ID	http://purl.obolibrary.org/obo/dinto_DB00310
AHFScode	40:28.24
ATCCode	C03BA04
CASRN	77-36-1
DBBrand	zambesil renon oradil hygroton phthalamodine higroton saluretin igroton natriuran thalitone isoren hydro-long phthalamudine
DBSynonym	chlorothalidone chlorphthalidone chlorthalidon chlorphthalidolone chlortalidone
Definition	A benzenesulfonamide-phthalimidine that tautomerizes to a benzophenones form. It is considered a thiazide-like diuretic. [PubChem]
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0001520 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000921 http://purl.obolibrary.org/obo/OAE_0000195 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000365 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0001053 http://purl.obolibrary.org/obo/OAE_0000287 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0000851 http://purl.obolibrary.org/obo/OAE_0000268 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0001106 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0000468 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000487 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000565
has pharmacological target	http://purl.obolibrary.org/obo/dinto_0231
InChI	InChI=1S/C14H11ClN2O4S/c15-11-6-5-8(7-12(11)22(16,20)21)14(19)10-4-2-1-3-9(10)13(18)17-14/h1-7,19H,(H,17,18)(H2,16,20,21)
InChIKey	InChIKey=JIVPVXMEBJLZRO-UHFFFAOYSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_0231
label	chlorthalidone
may interact with	http://purl.obolibrary.org/obo/dinto_DB00469 http://purl.obolibrary.org/obo/dinto_DB00519 http://purl.obolibrary.org/obo/CHEBI_4551 http://purl.obolibrary.org/obo/CHEBI_31468 http://purl.obolibrary.org/obo/dinto_DB01356 http://purl.obolibrary.org/obo/CHEBI_50861 http://purl.obolibrary.org/obo/dinto_DB01396 http://purl.obolibrary.org/obo/CHEBI_4495 http://purl.obolibrary.org/obo/CHEBI_68575 http://purl.obolibrary.org/obo/CHEBI_4681
prefixIRI	obo2:dinto_DB00310
prefLabel	chlorthalidone
SMILES	NS(=O)(=O)C1=C(Cl)C=CC(=C1)C1(O)NC(=O)C2=CC=CC=C12
Synonym	C14H11ClN2O4S 2-chloro-5-(1-hydroxy-3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzene-1-sulfonamide
xref	Drugs.com:http://www.drugs.com/cdi/chlorthalidone.html ChemSpider:2631 Drugs Product Database (DPD):360279 PharmGKB:PA448970 Wikipedia:http://en.wikipedia.org/wiki/Chlorthalidone BindingDB:25900 National Drug Code Directory:0179-0015-01 RxList:http://www.rxlist.com/cgi/generic3/chlorthalidone.htm PubChem Substance:46505541 ChEBI:3654 PubChem Compound:2732
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_3654	CHEBI	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.522.223.500	RH-MESH	LOOM
http://purl.bioontology.org/ontology/VANDF/4017887	VANDF	LOOM
http://purl.obolibrary.org/obo/CHEBI_3654	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_3654	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_3654	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_3654	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_3654	NIFSTD	LOOM
http://bmi.utah.edu/ontologies/hfontology/C0008294	HFO	LOOM
http://purl.bioontology.org/ontology/MESH/D002752	MESH	LOOM
http://purl.bioontology.org/ontology/RCD/b23..	RCD	LOOM
http://purl.bioontology.org/ontology/NDDF/002309	NDDF	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00015951	PMAPP-PMO	LOOM
http://purl.jp/bio/4/id/200906054539208062	IOBC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.478.600.500	RH-MESH	LOOM
http://www.drugbank.ca/drugs/DB00310	FTC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.559.389.115.124.500	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.065.884.365	RH-MESH	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146240	NDFRT	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#2846	OCHV	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.513.750.500	RH-MESH	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0008294	OCHV	LOOM
http://purl.bioontology.org/ontology/LNC/LP16077-7	LOINC	LOOM
http://stirdf.jst.go.jp/id/200907038211877550	IOBC	LOOM
https://go.drugbank.com/drugs/DB00310	MDM	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.590.700.365	RH-MESH	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387324004	SNOMEDCT	LOOM
http://purl.obolibrary.org/obo/MESH_D002752	BERO	LOOM
http://purl.obolibrary.org/obo/OMIT_0004073	OMIT	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47449	NCIT	LOOM
http://purl.obolibrary.org/obo/NCIT_C47449	BERO	LOOM
http://purl.bioontology.org/ontology/SNMI/C-72240	SNMI	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D002752	RH-MESH	LOOM
http://purl.bioontology.org/ontology/RXNORM/2409	RXNORM	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU006890	LOINC	LOOM