The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	ranolazine
Synonyms	C24H33N3O4 N-(2,6-dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}acetamide
ID	http://purl.obolibrary.org/obo/dinto_DB00243
ATCCode	C01EB18
CASRN	142387-99-3
DBBrand	ranexa
DBSynonym	(-)-ranolazine ranolazine dihydrochloride ranolazine 2hcl
Definition	Ranolazine is an antianginal medication. On January 31, 2006, ranolazine was approved for use in the United States by the FDA for the treatment of chronic angina. [Wikipedia]
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000879 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0001045 http://purl.obolibrary.org/obo/OAE_0000218 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000443 http://purl.obolibrary.org/obo/OAE_0000512 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000317 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000920 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0001275 http://purl.obolibrary.org/obo/OAE_0000455 http://purl.obolibrary.org/obo/OAE_0000084 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0001341 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0000607 http://purl.obolibrary.org/obo/OAE_0001164 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000501 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0001364 http://purl.obolibrary.org/obo/OAE_0000402
has pharmacological target	http://purl.obolibrary.org/obo/dinto_1670
InChI	InChI=1S/C24H33N3O4/c1-18-7-6-8-19(2)24(18)25-23(29)16-27-13-11-26(12-14-27)15-20(28)17-31-22-10-5-4-9-21(22)30-3/h4-10,20,28H,11-17H2,1-3H3,(H,25,29)
InChIKey	InChIKey=XKLMZUWKNUAPSZ-UHFFFAOYSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_1670 http://purl.obolibrary.org/obo/dinto_4078 http://purl.obolibrary.org/obo/dinto_2993
is metabolised by	http://purl.obolibrary.org/obo/dinto_0901
label	ranolazine
may interact with	http://purl.obolibrary.org/obo/CHEBI_32250 http://purl.obolibrary.org/obo/CHEBI_9948 http://purl.obolibrary.org/obo/CHEBI_4551 http://purl.obolibrary.org/obo/CHEBI_6997 http://purl.obolibrary.org/obo/CHEBI_41774 http://purl.obolibrary.org/obo/CHEBI_37924 http://purl.obolibrary.org/obo/dinto_DB00224 http://purl.obolibrary.org/obo/dinto_DB00196 http://purl.obolibrary.org/obo/CHEBI_101278 http://purl.obolibrary.org/obo/CHEBI_40050 http://purl.obolibrary.org/obo/CHEBI_156095 http://purl.obolibrary.org/obo/CHEBI_61049 http://purl.obolibrary.org/obo/dinto_DB00726 http://purl.obolibrary.org/obo/CHEBI_9150 http://purl.obolibrary.org/obo/CHEBI_63622 http://purl.obolibrary.org/obo/CHEBI_63632 http://purl.obolibrary.org/obo/CHEBI_3172 http://purl.obolibrary.org/obo/CHEBI_9566 http://purl.obolibrary.org/obo/CHEBI_51364 http://purl.obolibrary.org/obo/CHEBI_474014 http://purl.obolibrary.org/obo/dinto_DB01167 http://purl.obolibrary.org/obo/CHEBI_3764 http://purl.obolibrary.org/obo/CHEBI_63621 http://purl.obolibrary.org/obo/CHEBI_681850 http://purl.obolibrary.org/obo/dinto_DB00582 http://purl.obolibrary.org/obo/dinto_DB00308 http://purl.obolibrary.org/obo/CHEBI_10119 http://purl.obolibrary.org/obo/CHEBI_9635 http://purl.obolibrary.org/obo/CHEBI_3732 http://purl.obolibrary.org/obo/CHEBI_9622 http://purl.obolibrary.org/obo/CHEBI_9398 http://purl.obolibrary.org/obo/CHEBI_63628 http://purl.obolibrary.org/obo/CHEBI_45716 http://purl.obolibrary.org/obo/CHEBI_28593 http://purl.obolibrary.org/obo/dinto_DB01118 http://purl.obolibrary.org/obo/dinto_DB00199 http://purl.obolibrary.org/obo/CHEBI_3090 http://purl.obolibrary.org/obo/dinto_DB00503 http://purl.obolibrary.org/obo/dinto_DB01319 http://purl.obolibrary.org/obo/CHEBI_4657 http://purl.obolibrary.org/obo/dinto_DB01026 http://purl.obolibrary.org/obo/CHEBI_8428 http://purl.obolibrary.org/obo/CHEBI_195280 http://purl.obolibrary.org/obo/dinto_DB00220 http://purl.obolibrary.org/obo/dinto_DB01623 http://purl.obolibrary.org/obo/CHEBI_4681 http://purl.obolibrary.org/obo/dinto_DB00976
prefixIRI	obo2:dinto_DB00243
prefLabel	ranolazine
SMILES	COC1=CC=CC=C1OCC(O)CN1CCN(CC(=O)NC2=C(C)C=CC=C2C)CC1
Synonym	C24H33N3O4 N-(2,6-dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}acetamide
xref	National Drug Code Directory:61958-1001-1 RxList:http://www.rxlist.com/cgi/generic/ranexa.htm ChemSpider:51354 PubChem Substance:46505145 PharmGKB:PA164746007 PubChem Compound:56959 Wikipedia:http://en.wikipedia.org/wiki/Ranolazine Drugs.com:http://www.drugs.com/cdi/ranolazine.html
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_87681	CHEBI	LOOM
http://purl.jp/bio/4/id/200906086477921017	IOBC	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000171743	NDFRT	LOOM
http://purl.obolibrary.org/obo/NCIT_C66507	BERO	LOOM
http://purl.obolibrary.org/obo/OMIT_0001446	OMIT	LOOM
https://go.drugbank.com/drugs/DB00243	MDM	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66507	NCIT	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00015822	PMAPP-PMO	LOOM
http://purl.bioontology.org/ontology/RXNORM/35829	RXNORM	LOOM
http://www.drugbank.ca/drugs/DB00243	FTC	LOOM
http://purl.obolibrary.org/obo/CHEBI_87681	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_87681	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_87681	DRON	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000753754	PDQ	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/420365007	SNOMEDCT	LOOM
http://purl.bioontology.org/ontology/MESH/D000069458	MESH	LOOM
http://bmi.utah.edu/ontologies/hfontology/C0073633	HFO	LOOM
http://purl.bioontology.org/ontology/VANDF/4025078	VANDF	LOOM
http://stirdf.jst.go.jp/id/200907035352737923	IOBC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C055512	RH-MESH	LOOM
http://purl.bioontology.org/ontology/NDDF/011195	NDDF	LOOM
http://purl.obolibrary.org/obo/MESH_D000069458	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_87690	FIDEO	LOOM
http://purl.bioontology.org/ontology/ATC/C01EB18	ATC	LOOM