loading...| Preferred Name |
filgrastim |
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| Synonyms |
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| ID |
http://purl.obolibrary.org/obo/dinto_DB00099 |
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| activates | ||
| AHFScode |
20:16.00 |
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| ATCCode |
L03AA02 |
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| CASRN |
121181-53-1 |
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| DBBrand |
biocilin zarzio filgen nivestim recombicyte neukine inmunef biofigran filatil grimatin neutromax leucostim endufil scilocyte gran biofilgran tevagastrim macroleuco granulokine neutroval jiexin white-c leucogen neupogen |
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| DBSynonym |
g-csf tbo-filgrastim granulocyte colony stimulating factor |
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| Definition |
Filgrastim is a recombinant, non-pegylated human granulocyte colony stimulating factor (G-CSF) analogue manufactured by recombinant DNA technology using a strain of E. coli. It is marketed as the brand name Neupogen by Amgen. Chemically, it consists of 175 amino acid residues. The protein has an amino acid sequence that is identical to the natural sequence predicted from human DNA sequence analysis, except for the addition of an N-terminal methionine necessary for expression in E coli. Tbo-filgrastim, which is marketed by Sicor Biotech and FDA approved on August 29, 2012, contains the same active ingredient as Neupogen and is biologically similar, but it is formulated to be short-acting. |
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| has pharmacological target | ||
| label |
filgrastim |
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| may interact with | ||
| prefixIRI |
obo2:dinto_DB00099 |
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| prefLabel |
filgrastim |
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| related with | ||
| xref |
UniProtKB:P09919 GenBank:X03438 Drugs Product Database (DPD):1968017 PharmGKB:PA449626 National Drug Code Directory:55513-209-10 RxList:http://www.rxlist.com/cgi/generic/filgrastim.htm Drugs.com:http://www.drugs.com/cdi/filgrastim.html Wikipedia:http://en.wikipedia.org/wiki/Filgrastim |
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| subClassOf |