calcium-activated potassium channel subunit alpha 1

bkca alpha

http://purl.obolibrary.org/obo/dinto_3879

Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX)

DrugBank Database

kcnma1

http://purl.obolibrary.org/obo/CHEBI_3013

http://purl.obolibrary.org/obo/CHEBI_59773

http://purl.obolibrary.org/obo/CHEBI_5615

http://purl.obolibrary.org/obo/dinto_DB01110

http://purl.obolibrary.org/obo/dinto_DB00228

http://purl.obolibrary.org/obo/CHEBI_3655

http://purl.obolibrary.org/obo/CHEBI_59773

http://purl.obolibrary.org/obo/CHEBI_3013

http://purl.obolibrary.org/obo/dinto_DB00228

calcium-activated potassium channel subunit alpha 1

human

obo2:dinto_3879

calcium-activated potassium channel subunit alpha 1

http://purl.obolibrary.org/obo/CHEBI_3655

http://purl.obolibrary.org/obo/dinto_DB00774

http://purl.obolibrary.org/obo/dinto_DB00999

http://purl.obolibrary.org/obo/CHEBI_4495

bkca alpha

slo1

slo-alpha

slowpoke homolog

calcium-activated potassium channel, subfamily m subunit alpha 1

kca1.1

slo homolog

hslo

maxi k channel

maxik

k(vca)alpha

bk channel

UniProt ID:Q12791

DrugBank:610

http://purl.obolibrary.org/obo/dinto_000128