loading...| Preferred Name |
insulin receptor |
|
| Synonyms |
ir |
|
| ID |
http://purl.obolibrary.org/obo/dinto_0892 |
|
| Definition |
This receptor binds insulin and has a tyrosine-protein kinase activity. Isoform Short has a higher affinity for insulin. Mediates the metabolic functions of insulin. Binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). Can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1 |
|
| definition source |
DrugBank Database |
|
| Gene |
insr |
|
| is activated by |
http://purl.obolibrary.org/obo/dinto_DB01307 http://purl.obolibrary.org/obo/dinto_DB01306 http://purl.obolibrary.org/obo/CHEBI_5931 http://purl.obolibrary.org/obo/dinto_DB08914 http://purl.obolibrary.org/obo/dinto_DB00047 |
|
| is binded by | ||
| is pharmacological target of |
http://purl.obolibrary.org/obo/dinto_DB01307 http://purl.obolibrary.org/obo/dinto_DB01306 http://purl.obolibrary.org/obo/CHEBI_5931 http://purl.obolibrary.org/obo/dinto_DB00071 http://purl.obolibrary.org/obo/dinto_DB08914 http://purl.obolibrary.org/obo/dinto_DB00047 |
|
| label |
insulin receptor |
|
| OrganismClass |
human |
|
| prefixIRI |
obo2:dinto_0892 |
|
| prefLabel |
insulin receptor |
|
| related with |
http://purl.obolibrary.org/obo/dinto_DB01277 |
|
| Synonym |
ir cd220 antigen ec 2.7.10.1 insulin receptor precursor |
|
| xref |
DrugBank:36 UniProt ID:P06213 |
|
| subClassOf |