The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	verapamil
Synonyms	C27H38N2O4 Verapamil verapamilum 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile verapamilo verapamil
ID	http://purl.obolibrary.org/obo/CHEBI_9948
AHFScode	24:28.92
ATCCode	C08DA01
CASRN	52-53-9
DBBrand	verelan cardibeltin iproveratril calan arpamyl apo-verap isoptin sr novo-veramil veramex isoptimo covera-hs cardiagutt drosteakard dilacoran dignover univer securon veracim geangin isoptin calan sr berkatens quasar vasolan verelan pm nu-verap veraptin cordilox verexamil
DBname	verapamil
DBSynonym	verapamil hcl verapamilo [inn-spanish] verapamil [usan:ban:inn] verapamilum [inn-latin]
Definition	An L-type calcium channel blocker of the phenylalkylamine class.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0001297 http://purl.obolibrary.org/obo/OAE_0000785 http://purl.obolibrary.org/obo/OAE_0000449 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0001373 http://purl.obolibrary.org/obo/OAE_0000081 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000630 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000921 http://purl.obolibrary.org/obo/OAE_0000567 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0000319 http://purl.obolibrary.org/obo/OAE_0000021 http://purl.obolibrary.org/obo/OAE_0001370 http://purl.obolibrary.org/obo/OAE_0000333 http://purl.obolibrary.org/obo/OAE_0001069 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0001025 http://purl.obolibrary.org/obo/OAE_0000677 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000207 http://purl.obolibrary.org/obo/OAE_0000539 http://purl.obolibrary.org/obo/OAE_0000770 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0001468 http://purl.obolibrary.org/obo/OAE_0001068 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000607 http://purl.obolibrary.org/obo/OAE_0000038 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0000343 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000468 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000487 http://purl.obolibrary.org/obo/OAE_0000779 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000565 http://purl.obolibrary.org/obo/OAE_0001345 http://purl.obolibrary.org/obo/OAE_0001001 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000242 http://purl.obolibrary.org/obo/OAE_0000358 http://purl.obolibrary.org/obo/OAE_0001309 http://purl.obolibrary.org/obo/OAE_0000534 http://purl.obolibrary.org/obo/OAE_0000811 http://purl.obolibrary.org/obo/OAE_0000350
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2962 http://purl.obolibrary.org/obo/dinto_2965 http://purl.obolibrary.org/obo/dinto_2957 http://purl.obolibrary.org/obo/dinto_2959 http://purl.obolibrary.org/obo/dinto_2975 http://purl.obolibrary.org/obo/dinto_2979 http://purl.obolibrary.org/obo/dinto_1110 http://purl.obolibrary.org/obo/dinto_1027
has role	http://purl.obolibrary.org/obo/CHEBI_38070 http://purl.obolibrary.org/obo/CHEBI_35620 http://purl.obolibrary.org/obo/CHEBI_38215
InChI	InChI=1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3
InChIKey	InChIKey=SGTNSNPWRIOYBX-UHFFFAOYSA-N
induces	http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_0465
inhibits	http://purl.obolibrary.org/obo/dinto_0023 http://purl.obolibrary.org/obo/dinto_0588 http://purl.obolibrary.org/obo/dinto_2814 http://purl.obolibrary.org/obo/dinto_1970 http://purl.obolibrary.org/obo/dinto_1973 http://purl.obolibrary.org/obo/dinto_2962 http://purl.obolibrary.org/obo/dinto_2965 http://purl.obolibrary.org/obo/dinto_3187 http://purl.obolibrary.org/obo/dinto_0887 http://purl.obolibrary.org/obo/dinto_0883 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_2957 http://purl.obolibrary.org/obo/dinto_2959 http://purl.obolibrary.org/obo/dinto_2975 http://purl.obolibrary.org/obo/dinto_2979 http://purl.obolibrary.org/obo/dinto_2019 http://purl.obolibrary.org/obo/dinto_1987 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_1540 http://purl.obolibrary.org/obo/dinto_3489 http://purl.obolibrary.org/obo/dinto_2828 http://purl.obolibrary.org/obo/dinto_1956 http://purl.obolibrary.org/obo/dinto_1110 http://purl.obolibrary.org/obo/dinto_2789 http://purl.obolibrary.org/obo/dinto_0931 http://purl.obolibrary.org/obo/dinto_1027 http://purl.obolibrary.org/obo/dinto_3628 http://purl.obolibrary.org/obo/dinto_0300 http://purl.obolibrary.org/obo/dinto_3464
is metabolised by	http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1956 http://purl.obolibrary.org/obo/dinto_1959 http://purl.obolibrary.org/obo/dinto_1221 http://purl.obolibrary.org/obo/dinto_0465
is transported by	http://purl.obolibrary.org/obo/dinto_1440
label	verapamil
may interact with	http://purl.obolibrary.org/obo/dinto_DB00683 http://purl.obolibrary.org/obo/CHEBI_8214 http://purl.obolibrary.org/obo/CHEBI_32250 http://purl.obolibrary.org/obo/CHEBI_68478 http://purl.obolibrary.org/obo/CHEBI_102524 http://purl.obolibrary.org/obo/dinto_DB01303 http://purl.obolibrary.org/obo/CHEBI_4551 http://purl.obolibrary.org/obo/CHEBI_119573 http://purl.obolibrary.org/obo/CHEBI_8107 http://purl.obolibrary.org/obo/dinto_DB00794 http://purl.obolibrary.org/obo/CHEBI_102166 http://purl.obolibrary.org/obo/CHEBI_37924 http://purl.obolibrary.org/obo/dinto_DB00243 http://purl.obolibrary.org/obo/dinto_DB00224 http://purl.obolibrary.org/obo/CHEBI_3223 http://purl.obolibrary.org/obo/dinto_DB00196 http://purl.obolibrary.org/obo/CHEBI_8499 http://purl.obolibrary.org/obo/CHEBI_40050 http://purl.obolibrary.org/obo/CHEBI_70746 http://purl.obolibrary.org/obo/dinto_DB01223 http://purl.obolibrary.org/obo/CHEBI_31547 http://purl.obolibrary.org/obo/CHEBI_4856 http://purl.obolibrary.org/obo/dinto_DB06207 http://purl.obolibrary.org/obo/CHEBI_4031 http://purl.obolibrary.org/obo/dinto_DB01394 http://purl.obolibrary.org/obo/CHEBI_61049 http://purl.obolibrary.org/obo/CHEBI_45304 http://purl.obolibrary.org/obo/CHEBI_102216 http://purl.obolibrary.org/obo/CHEBI_9150 http://purl.obolibrary.org/obo/dinto_DB04855 http://purl.obolibrary.org/obo/CHEBI_8069 http://purl.obolibrary.org/obo/dinto_DB00312 http://purl.obolibrary.org/obo/dinto_DB00342 http://purl.obolibrary.org/obo/CHEBI_3127 http://purl.obolibrary.org/obo/CHEBI_63632 http://purl.obolibrary.org/obo/CHEBI_7494 http://purl.obolibrary.org/obo/CHEBI_40303 http://purl.obolibrary.org/obo/dinto_DB01601 http://purl.obolibrary.org/obo/dinto_DB00373 http://purl.obolibrary.org/obo/dinto_DB01167 http://purl.obolibrary.org/obo/CHEBI_3441 http://purl.obolibrary.org/obo/CHEBI_63621 http://purl.obolibrary.org/obo/CHEBI_681850 http://purl.obolibrary.org/obo/CHEBI_9654 http://purl.obolibrary.org/obo/dinto_DB00582 http://purl.obolibrary.org/obo/dinto_DB00237 http://purl.obolibrary.org/obo/dinto_DB06212 http://purl.obolibrary.org/obo/dinto_DB01558 http://purl.obolibrary.org/obo/CHEBI_2904 http://purl.obolibrary.org/obo/dinto_DB01356 http://purl.obolibrary.org/obo/dinto_DB01110 http://purl.obolibrary.org/obo/CHEBI_6758 http://purl.obolibrary.org/obo/CHEBI_3387 http://purl.obolibrary.org/obo/CHEBI_39548 http://purl.obolibrary.org/obo/CHEBI_3732 http://purl.obolibrary.org/obo/CHEBI_6904 http://purl.obolibrary.org/obo/CHEBI_9622 http://purl.obolibrary.org/obo/CHEBI_50861 http://purl.obolibrary.org/obo/CHEBI_64355 http://purl.obolibrary.org/obo/CHEBI_45367 http://purl.obolibrary.org/obo/CHEBI_9398 http://purl.obolibrary.org/obo/CHEBI_2379 http://purl.obolibrary.org/obo/CHEBI_63628 http://purl.obolibrary.org/obo/dinto_DB01351 http://purl.obolibrary.org/obo/dinto_DB00073 http://purl.obolibrary.org/obo/dinto_DB01580 http://purl.obolibrary.org/obo/CHEBI_28593 http://purl.obolibrary.org/obo/dinto_DB01396 http://purl.obolibrary.org/obo/dinto_DB01118 http://purl.obolibrary.org/obo/dinto_DB00199 http://purl.obolibrary.org/obo/CHEBI_7444 http://purl.obolibrary.org/obo/CHEBI_7447 http://purl.obolibrary.org/obo/dinto_DB00503 http://purl.obolibrary.org/obo/dinto_DB01319 http://purl.obolibrary.org/obo/dinto_DB01369 http://purl.obolibrary.org/obo/CHEBI_2636 http://purl.obolibrary.org/obo/dinto_DB01218 http://purl.obolibrary.org/obo/CHEBI_6343 http://purl.obolibrary.org/obo/dinto_DB01026 http://purl.obolibrary.org/obo/CHEBI_28177 http://purl.obolibrary.org/obo/CHEBI_68575 http://purl.obolibrary.org/obo/CHEBI_8364 http://purl.obolibrary.org/obo/CHEBI_367163 http://purl.obolibrary.org/obo/CHEBI_28077 http://purl.obolibrary.org/obo/CHEBI_9674 http://purl.obolibrary.org/obo/dinto_DB00220 http://purl.obolibrary.org/obo/dinto_DB00622 http://purl.obolibrary.org/obo/CHEBI_9073 http://purl.obolibrary.org/obo/CHEBI_4681 http://purl.obolibrary.org/obo/dinto_DB00976 http://purl.obolibrary.org/obo/CHEBI_45783 http://purl.obolibrary.org/obo/dinto_DB00951
prefixIRI	obo2:CHEBI_9948
prefLabel	verapamil
related with	http://purl.obolibrary.org/obo/dinto_1670 http://purl.obolibrary.org/obo/dinto_2714
SMILES	COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC COC1=C(OC)C=C(CCN(C)CCCC(C#N)(C(C)C)C2=CC(OC)=C(OC)C=C2)C=C1
Synonym	C27H38N2O4 Verapamil verapamilum 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile verapamilo verapamil
xref	Wikipedia:http://en.wikipedia.org/wiki/Verapamil PharmGKB:PA451868 Beilstein:2825000 ChemSpider:2425 DrugBank:DB00661 National Drug Code Directory:0091-4085-01 ChEMBL:101219 PubChem Substance:46508158 RxList:http://www.rxlist.com/cgi/generic/verapsr.htm PubChem Compound:2520 KEGG DRUG:D02356 CASRN:52-53-9 IUPHAR:2406 Drugs.com:http://www.drugs.com/verapamil.html Guide To Pharmacology:2406 BindingDB:50005628 KEGG COMPOUND:C07188 Drugs Product Database (DPD):2239769 ChEBI:9948
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_9948	EFO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9948	PHIPO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9948	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9948	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9948	FIDEO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9948	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9948	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9948	DRON	SAME_URI
http://purl.obolibrary.org/obo/XCO_0000616	XCO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9948	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9948	PHIPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9948	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_9948	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9948	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9948	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9948	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_9948	DRON	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0042523	OCHV	LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass5df0ba96_9e76_436e_987c_ddef6612dd7b	WWECA	LOOM
http://purl.jp/bio/4/id/200906076642470240	IOBC	LOOM
http://purl.jp/bio/4/id/200906075738916960	IOBC	LOOM
http://doe-generated-ontology.com/OntoAD#C0042523	ONTOAD	LOOM
http://stirdf.jst.go.jp/id/200907009098573680	IOBC	LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Verapamil	APAONTO	LOOM
https://go.drugbank.com/drugs/DB00661	MDM	LOOM
http://purl.jp/bio/4/id/200906017005265599	IOBC	LOOM
http://purl.bioontology.org/ontology/VANDF/4019969	VANDF	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU007771	LOINC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.092.471.683.953	RH-MESH	LOOM
http://purl.bioontology.org/ontology/CSP/2268-7394	CRISP	LOOM
http://stirdf.jst.go.jp/id/200907065943493604	IOBC	LOOM
http://mimi.case.edu/ontologies/2009/9/DrugOntology#verapamil	SDO	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372754009	SNOMEDCT	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C928	NCIT	LOOM
http://purl.bioontology.org/ontology/RCD/x01QU	RCD	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D014700	RH-MESH	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039730	PDQ	LOOM
http://www.drugbank.ca/drugs/DB00661	FTC	LOOM
http://purl.bioontology.org/ontology/SNMI/C-80490	SNMI	LOOM
http://purl.obolibrary.org/obo/MESH_D014700	BERO	LOOM
http://purl.jp/bio/4/id/200906047107040601	IOBC	LOOM
http://purl.bioontology.org/ontology/NDDF/004515	NDDF	LOOM
http://purl.bioontology.org/ontology/MESH/D014700	MESH	LOOM
http://purl.bioontology.org/ontology/LNC/LP16307-8	LOINC	LOOM
http://purl.bioontology.org/ontology/ATC/C08DA01	ATC	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016177	PMAPP-PMO	LOOM
http://stirdf.jst.go.jp/id/200907001651458621	IOBC	LOOM
http://www.co-ode.org/ontologies/galen#Verapamil	GALEN	LOOM
http://www.gamuts.net/entity#verapamil	GAMUTS	LOOM
http://purl.obolibrary.org/obo/OMIT_0015532	OMIT	LOOM
http://purl.bioontology.org/ontology/RXNORM/11170	RXNORM	LOOM
http://purl.obolibrary.org/obo/ARO_3007333	ARO	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148054	NDFRT	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148054	OCVDAE	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#12957	OCHV	LOOM
http://bmi.utah.edu/ontologies/hfontology/C0042523	HFO	LOOM
http://stirdf.jst.go.jp/id/200907073876348656	IOBC	LOOM
http://purl.obolibrary.org/obo/NCIT_C928	BERO	LOOM